ELOVL2 — 43 ClinVar variants
All ClinVar germline ELOVL2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 41 flagged for review →
43 Uncertain significance
Full ELOVL2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 41
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 35
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ELOVL2 p.Ala151Ser Uncertain significance Single submitter
- ELOVL2 p.Ala80Val Uncertain significance Single submitter
- ELOVL2 p.Arg111Trp Uncertain significance Single submitter
- ELOVL2 p.Arg136Trp Uncertain significance Single submitter
- ELOVL2 p.Arg22Gln Uncertain significance Single submitter
- ELOVL2 p.Arg25Gln Uncertain significance Single submitter
- ELOVL2 p.Asn12Ser Uncertain significance Single submitter
- ELOVL2 p.Asn292Lys Uncertain significance Single submitter
- ELOVL2 p.Asn96Lys Uncertain significance Single submitter
- ELOVL2 p.Asp129His Uncertain significance Single submitter
- ELOVL2 p.Cys228Arg Uncertain significance Single submitter
- ELOVL2 p.Gln255Arg Uncertain significance Single submitter
- ELOVL2 p.Gln98Glu Uncertain significance Single submitter
- ELOVL2 p.Gly93Ala Uncertain significance Single submitter
- ELOVL2 p.Ile110Met Uncertain significance Single submitter
- ELOVL2 p.Ile131Val Uncertain significance Single submitter
- ELOVL2 p.Ile142Val Uncertain significance Single submitter
- ELOVL2 p.Leu145Ile Uncertain significance Single submitter
- ELOVL2 p.Leu36Phe Uncertain significance Single submitter
- ELOVL2 p.Leu62Val Uncertain significance Single submitter
- ELOVL2 p.Lys137Glu Uncertain significance Single submitter
- ELOVL2 p.Lys273Glu Uncertain significance Single submitter
- ELOVL2 p.Met262Leu Uncertain significance Single submitter
- ELOVL2 p.Met262Thr Uncertain significance Single submitter
- ELOVL2 p.Met266Thr Uncertain significance Single submitter
- ELOVL2 p.Met291Val Uncertain significance Single submitter
- ELOVL2 p.Pro270Thr Uncertain significance Single submitter
- ELOVL2 p.Thr218Met Uncertain significance Single submitter
- ELOVL2 p.Thr244Lys Uncertain significance Single submitter
- ELOVL2 p.Thr244Met Uncertain significance Single submitter
- ELOVL2 p.Tyr184Cys Uncertain significance Single submitter
- ELOVL2 p.Tyr204His Uncertain significance Single submitter
- ELOVL2 p.Val214Met Uncertain significance Single submitter
- ELOVL2 p.Val254Ile Uncertain significance Single submitter
- ELOVL2 p.Val290Ala Uncertain significance Single submitter
Predictors split 6
The independent predictors disagree with each other — read with care.
- ELOVL2 p.Arg111Gln Uncertain significance Multiple submitters
- ELOVL2 p.Asn251Ser Uncertain significance Single submitter
- ELOVL2 p.Gly229Ala Uncertain significance Single submitter
- ELOVL2 p.Gly278Val Uncertain significance Single submitter
- ELOVL2 p.Pro21Leu Uncertain significance Single submitter
- ELOVL2 p.Pro227Gln Uncertain significance Single submitter
All ELOVL2 variants
Uncertain significance 43
- p.Arg111Gln Multiple submitters ⚠
- p.Ala151Ser Single submitter ⚠
- p.Ala80Val Single submitter ⚠
- p.Arg111Trp Single submitter ⚠
- p.Arg136Trp Single submitter ⚠
- p.Arg22Gln Single submitter ⚠
- p.Arg25Gln Single submitter ⚠
- p.Asn12Ser Single submitter ⚠
- p.Asn251Ser Single submitter ⚠
- p.Asn292Lys Single submitter ⚠
- p.Asn96Lys Single submitter ⚠
- p.Asp129His Single submitter ⚠
- p.Cys228Arg Single submitter ⚠
- p.Gln255Arg Single submitter ⚠
- p.Gln98Glu Single submitter ⚠
- p.Gly229Ala Single submitter ⚠
- p.Gly278Val Single submitter ⚠
- p.Gly93Ala Single submitter ⚠
- p.Ile110Met Single submitter ⚠
- p.Ile131Val Single submitter ⚠
- p.Ile142Val Single submitter ⚠
- p.Leu135Val Single submitter
- p.Leu145Ile Single submitter ⚠
- p.Leu36Phe Single submitter ⚠
- p.Leu62Val Single submitter ⚠
- p.Lys137Glu Single submitter ⚠
- p.Lys273Glu Single submitter ⚠
- p.Met262Leu Single submitter ⚠
- p.Met262Thr Single submitter ⚠
- p.Met266Thr Single submitter ⚠
- p.Met291Val Single submitter ⚠
- p.Pro21Leu Single submitter ⚠
- p.Pro227Gln Single submitter ⚠
- p.Pro270Thr Single submitter ⚠
- p.Pro37Ser Single submitter
- p.Thr218Met Single submitter ⚠
- p.Thr244Lys Single submitter ⚠
- p.Thr244Met Single submitter ⚠
- p.Tyr184Cys Single submitter ⚠
- p.Tyr204His Single submitter ⚠
- p.Val214Met Single submitter ⚠
- p.Val254Ile Single submitter ⚠
- p.Val290Ala Single submitter ⚠