ELOVL7 — 32 ClinVar variants
All ClinVar germline ELOVL7 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 31 flagged for review →
2 Likely benign · 30 Uncertain significance
Full ELOVL7 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 31
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 18
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ELOVL7 p.Arg137His Uncertain significance Single submitter
- ELOVL7 p.Asn278Ile Uncertain significance Single submitter
- ELOVL7 p.Asp130His Uncertain significance Single submitter
- ELOVL7 p.Asp230Asn Uncertain significance Single submitter
- ELOVL7 p.Cys276Tyr Uncertain significance Single submitter
- ELOVL7 p.Gln224Arg Uncertain significance Single submitter
- ELOVL7 p.His147Arg Uncertain significance Single submitter
- ELOVL7 p.His181Pro Uncertain significance Single submitter
- ELOVL7 p.Ile101Met Uncertain significance Single submitter
- ELOVL7 p.Ile222Arg Uncertain significance Single submitter
- ELOVL7 p.Leu193Met Uncertain significance Single submitter
- ELOVL7 p.Lys124Arg Uncertain significance Single submitter
- ELOVL7 p.Phe134Leu Uncertain significance Single submitter
- ELOVL7 p.Thr38Ala Uncertain significance Single submitter
- ELOVL7 p.Trp91Arg Uncertain significance Single submitter
- ELOVL7 p.Tyr233Phe Uncertain significance Single submitter
- ELOVL7 p.Tyr44Cys Uncertain significance Single submitter
- ELOVL7 p.Val48Phe Uncertain significance Single submitter
Predictors split 13
The independent predictors disagree with each other — read with care.
- ELOVL7 p.Arg106Gln Likely benign Single submitter
- ELOVL7 p.Arg98Gln Uncertain significance Single submitter
- ELOVL7 p.Asn140Asp Uncertain significance Single submitter
- ELOVL7 p.Asn273Ser Uncertain significance Single submitter
- ELOVL7 p.Gly264Asp Uncertain significance Single submitter
- ELOVL7 p.Lys277Arg Uncertain significance Single submitter
- ELOVL7 p.Pro195Ser Uncertain significance Single submitter
- ELOVL7 p.Ser191Tyr Uncertain significance Single submitter
- ELOVL7 p.Ser8Leu Uncertain significance Single submitter
- ELOVL7 p.Thr171Ser Uncertain significance Single submitter
- ELOVL7 p.Thr70Met Uncertain significance Single submitter
- ELOVL7 p.Tyr206Cys Uncertain significance Single submitter
- ELOVL7 p.Val213Phe Uncertain significance Single submitter
All ELOVL7 variants
Likely benign 2
- c.-85-3412G>A Single submitter
- p.Arg106Gln Single submitter ⚠
Uncertain significance 30
- p.Arg137His Single submitter ⚠
- p.Arg98Gln Single submitter ⚠
- p.Asn140Asp Single submitter ⚠
- p.Asn273Ser Single submitter ⚠
- p.Asn278Ile Single submitter ⚠
- p.Asp130His Single submitter ⚠
- p.Asp230Asn Single submitter ⚠
- p.Cys276Tyr Single submitter ⚠
- p.Gln224Arg Single submitter ⚠
- p.Gly264Asp Single submitter ⚠
- p.His147Arg Single submitter ⚠
- p.His181Pro Single submitter ⚠
- p.Ile101Met Single submitter ⚠
- p.Ile222Arg Single submitter ⚠
- p.Leu193Met Single submitter ⚠
- p.Lys124Arg Single submitter ⚠
- p.Lys277Arg Single submitter ⚠
- p.Phe134Leu Single submitter ⚠
- p.Pro195Ser Single submitter ⚠
- p.Ser191Tyr Single submitter ⚠
- p.Ser8Leu Single submitter ⚠
- p.Thr171Ser Single submitter ⚠
- p.Thr38Ala Single submitter ⚠
- p.Thr70Met Single submitter ⚠
- p.Trp91Arg Single submitter ⚠
- p.Tyr206Cys Single submitter ⚠
- p.Tyr233Phe Single submitter ⚠
- p.Tyr44Cys Single submitter ⚠
- p.Val213Phe Single submitter ⚠
- p.Val48Phe Single submitter ⚠