EML3 — 111 ClinVar variants
All ClinVar germline EML3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 110 flagged for review →
1 Likely benign · 110 Uncertain significance
Full EML3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 110
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 58
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- EML3 p.Ala178Ser Uncertain significance Single submitter
- EML3 p.Ala38Val Uncertain significance Single submitter
- EML3 p.Ala875Thr Uncertain significance Single submitter
- EML3 p.Arg141Gly Uncertain significance Single submitter
- EML3 p.Arg165Gln Uncertain significance Single submitter
- EML3 p.Arg167Pro Uncertain significance Single submitter
- EML3 p.Arg285Gln Uncertain significance Single submitter
- EML3 p.Arg360Gln Uncertain significance Single submitter
- EML3 p.Arg416His Uncertain significance Single submitter
- EML3 p.Arg611Cys Uncertain significance Single submitter
- EML3 p.Arg611His Uncertain significance Single submitter
- EML3 p.Arg771Gln Uncertain significance Single submitter
- EML3 p.Asn210Ser Uncertain significance Single submitter
- EML3 p.Asp194Glu Uncertain significance Single submitter
- EML3 p.Asp472Glu Uncertain significance Single submitter
- EML3 p.Asp64Gly Uncertain significance Single submitter
- EML3 p.Asp895Glu Uncertain significance Single submitter
- EML3 p.Cys420Tyr Uncertain significance Single submitter
- EML3 p.Gln110Arg Uncertain significance Single submitter
- EML3 p.Gly10Ser Uncertain significance Single submitter
- EML3 p.Gly125Ser Uncertain significance Single submitter
- EML3 p.Gly185Arg Uncertain significance Single submitter
- EML3 p.Gly192Glu Uncertain significance Single submitter
- EML3 p.Gly395Val Uncertain significance Single submitter
- EML3 p.Gly436Ser Uncertain significance Single submitter
- EML3 p.Gly499Ser Uncertain significance Single submitter
- EML3 p.Gly533Arg Uncertain significance Single submitter
- EML3 p.Gly698Cys Uncertain significance Single submitter
- EML3 p.Gly698Val Uncertain significance Single submitter
- EML3 p.Gly724Asp Uncertain significance Single submitter
- EML3 p.Gly781Asp Uncertain significance Single submitter
- EML3 p.His314Leu Uncertain significance Single submitter
- EML3 p.His647Gln Uncertain significance Single submitter
- EML3 p.Ile175Val Uncertain significance Single submitter
- EML3 p.Ile563Val Uncertain significance Single submitter
- EML3 p.Ile635Leu Uncertain significance Single submitter
- EML3 p.Lys493Glu Uncertain significance Single submitter
- EML3 p.Met834Arg Uncertain significance Single submitter
- EML3 p.Pro100Ser Uncertain significance Single submitter
- EML3 p.Pro106Ser Uncertain significance Single submitter
- EML3 p.Pro107Ser Uncertain significance Single submitter
- EML3 p.Pro136Ser Uncertain significance Single submitter
- EML3 p.Pro50Ser Uncertain significance Single submitter
- EML3 p.Pro59Ala Uncertain significance Single submitter
- EML3 p.Pro607Leu Uncertain significance Single submitter
- EML3 p.Pro61Ser Uncertain significance Single submitter
- EML3 p.Pro877Ser Uncertain significance Single submitter
- EML3 p.Ser163Pro Uncertain significance Single submitter
- EML3 p.Ser241Thr Uncertain significance Single submitter
- EML3 p.Ser249Arg Uncertain significance Single submitter
- EML3 p.Ser263Cys Uncertain significance Single submitter
- EML3 p.Ser892Ala Uncertain significance Single submitter
- EML3 p.Ser892Thr Uncertain significance Single submitter
- EML3 p.Thr325Ser Uncertain significance Single submitter
- EML3 p.Tyr748Cys Uncertain significance Single submitter
- EML3 p.Val308Ile Uncertain significance Single submitter
- EML3 p.Val379Leu Uncertain significance Single submitter
- EML3 p.Val560Ala Uncertain significance Single submitter
Predictors split 52
The independent predictors disagree with each other — read with care.
- EML3 p.Ala366Val Uncertain significance Single submitter
- EML3 p.Ala512Ser Uncertain significance Single submitter
- EML3 p.Arg165Trp Uncertain significance Single submitter
- EML3 p.Arg190Cys Uncertain significance Single submitter
- EML3 p.Arg205Gln Uncertain significance Single submitter
- EML3 p.Arg269Cys Uncertain significance Single submitter
- EML3 p.Arg285Trp Uncertain significance Single submitter
- EML3 p.Arg302Gln Uncertain significance Single submitter
- EML3 p.Arg534Trp Uncertain significance Single submitter
- EML3 p.Arg537Gln Uncertain significance Single submitter
- EML3 p.Arg582Ser Uncertain significance Single submitter
- EML3 p.Arg619Gln Uncertain significance Single submitter
- EML3 p.Arg619Trp Uncertain significance Single submitter
- EML3 p.Asn383Ser Uncertain significance Single submitter
- EML3 p.Asp850Glu Uncertain significance Single submitter
- EML3 p.Gln47Pro Uncertain significance Single submitter
- EML3 p.Gln540Arg Uncertain significance Single submitter
- EML3 p.Glu352Lys Uncertain significance Single submitter
- EML3 p.Gly101Asp Uncertain significance Single submitter
- EML3 p.Gly10Arg Uncertain significance Single submitter
- EML3 p.Gly242Arg Uncertain significance Single submitter
- EML3 p.Gly291Val Uncertain significance Single submitter
- EML3 p.Gly3Arg Uncertain significance Single submitter
- EML3 p.Gly3Trp Uncertain significance Single submitter
- EML3 p.Gly498Val Uncertain significance Single submitter
- EML3 p.Gly6Arg Uncertain significance Single submitter
- EML3 p.Gly836Arg Uncertain significance Single submitter
- EML3 p.Gly873Arg Uncertain significance Single submitter
- EML3 p.His300Tyr Uncertain significance Single submitter
- EML3 p.His647Tyr Uncertain significance Single submitter
- EML3 p.His804Arg Uncertain significance Single submitter
- EML3 p.His849Gln Uncertain significance Single submitter
- EML3 p.Leu140Phe Uncertain significance Single submitter
- EML3 p.Leu239Met Uncertain significance Single submitter
- EML3 p.Leu585Pro Uncertain significance Single submitter
- EML3 p.Leu693Phe Uncertain significance Single submitter
- EML3 p.Pro240Leu Uncertain significance Single submitter
- EML3 p.Pro463Ala Uncertain significance Single submitter
- EML3 p.Pro469Leu Uncertain significance Single submitter
- EML3 p.Pro554Thr Uncertain significance Single submitter
- EML3 p.Pro882Leu Uncertain significance Single submitter
- EML3 p.Ser171Cys Uncertain significance Single submitter
- EML3 p.Ser418Ile Uncertain significance Single submitter
- EML3 p.Ser649Asn Uncertain significance Single submitter
- EML3 p.Thr346Met Uncertain significance Single submitter
- EML3 p.Thr527Ala Uncertain significance Single submitter
- EML3 p.Val338Met Uncertain significance Single submitter
- EML3 p.Val411Ile Uncertain significance Single submitter
- EML3 p.Val560Met Uncertain significance Single submitter
- EML3 p.Val655Ile Uncertain significance Single submitter
- EML3 p.Val755Met Uncertain significance Single submitter
- EML3 p.Val869Met Uncertain significance Single submitter
All EML3 variants
Likely benign 1
- p.Ser56Pro Single submitter
Uncertain significance 110
- p.Ala178Ser Single submitter ⚠
- p.Ala366Val Single submitter ⚠
- p.Ala38Val Single submitter ⚠
- p.Ala512Ser Single submitter ⚠
- p.Ala875Thr Single submitter ⚠
- p.Arg141Gly Single submitter ⚠
- p.Arg165Gln Single submitter ⚠
- p.Arg165Trp Single submitter ⚠
- p.Arg167Pro Single submitter ⚠
- p.Arg190Cys Single submitter ⚠
- p.Arg205Gln Single submitter ⚠
- p.Arg269Cys Single submitter ⚠
- p.Arg285Gln Single submitter ⚠
- p.Arg285Trp Single submitter ⚠
- p.Arg302Gln Single submitter ⚠
- p.Arg360Gln Single submitter ⚠
- p.Arg416His Single submitter ⚠
- p.Arg534Trp Single submitter ⚠
- p.Arg537Gln Single submitter ⚠
- p.Arg582Ser Single submitter ⚠
- p.Arg611Cys Single submitter ⚠
- p.Arg611His Single submitter ⚠
- p.Arg619Gln Single submitter ⚠
- p.Arg619Trp Single submitter ⚠
- p.Arg771Gln Single submitter ⚠
- p.Asn210Ser Single submitter ⚠
- p.Asn383Ser Single submitter ⚠
- p.Asp194Glu Single submitter ⚠
- p.Asp472Glu Single submitter ⚠
- p.Asp64Gly Single submitter ⚠
- p.Asp850Glu Single submitter ⚠
- p.Asp895Glu Single submitter ⚠
- p.Cys420Tyr Single submitter ⚠
- p.Gln110Arg Single submitter ⚠
- p.Gln47Pro Single submitter ⚠
- p.Gln540Arg Single submitter ⚠
- p.Glu352Lys Single submitter ⚠
- p.Gly101Asp Single submitter ⚠
- p.Gly10Arg Single submitter ⚠
- p.Gly10Ser Single submitter ⚠
- p.Gly125Ser Single submitter ⚠
- p.Gly185Arg Single submitter ⚠
- p.Gly192Glu Single submitter ⚠
- p.Gly242Arg Single submitter ⚠
- p.Gly291Val Single submitter ⚠
- p.Gly395Val Single submitter ⚠
- p.Gly3Arg Single submitter ⚠
- p.Gly3Trp Single submitter ⚠
- p.Gly436Ser Single submitter ⚠
- p.Gly498Val Single submitter ⚠
- p.Gly499Ser Single submitter ⚠
- p.Gly533Arg Single submitter ⚠
- p.Gly698Cys Single submitter ⚠
- p.Gly698Val Single submitter ⚠
- p.Gly6Arg Single submitter ⚠
- p.Gly724Asp Single submitter ⚠
- p.Gly781Asp Single submitter ⚠
- p.Gly836Arg Single submitter ⚠
- p.Gly873Arg Single submitter ⚠
- p.His300Tyr Single submitter ⚠
- p.His314Leu Single submitter ⚠
- p.His647Gln Single submitter ⚠
- p.His647Tyr Single submitter ⚠
- p.His804Arg Single submitter ⚠
- p.His849Gln Single submitter ⚠
- p.Ile175Val Single submitter ⚠
- p.Ile563Val Single submitter ⚠
- p.Ile635Leu Single submitter ⚠
- p.Leu140Phe Single submitter ⚠
- p.Leu239Met Single submitter ⚠
- p.Leu585Pro Single submitter ⚠
- p.Leu693Phe Single submitter ⚠
- p.Lys493Glu Single submitter ⚠
- p.Met834Arg Single submitter ⚠
- p.Pro100Ser Single submitter ⚠
- p.Pro106Ser Single submitter ⚠
- p.Pro107Ser Single submitter ⚠
- p.Pro136Ser Single submitter ⚠
- p.Pro240Leu Single submitter ⚠
- p.Pro463Ala Single submitter ⚠
- p.Pro469Leu Single submitter ⚠
- p.Pro50Ser Single submitter ⚠
- p.Pro554Thr Single submitter ⚠
- p.Pro59Ala Single submitter ⚠
- p.Pro607Leu Single submitter ⚠
- p.Pro61Ser Single submitter ⚠
- p.Pro877Ser Single submitter ⚠
- p.Pro882Leu Single submitter ⚠
- p.Ser163Pro Single submitter ⚠
- p.Ser171Cys Single submitter ⚠
- p.Ser241Thr Single submitter ⚠
- p.Ser249Arg Single submitter ⚠
- p.Ser263Cys Single submitter ⚠
- p.Ser418Ile Single submitter ⚠
- p.Ser649Asn Single submitter ⚠
- p.Ser892Ala Single submitter ⚠
- p.Ser892Thr Single submitter ⚠
- p.Thr325Ser Single submitter ⚠
- p.Thr346Met Single submitter ⚠
- p.Thr527Ala Single submitter ⚠
- p.Tyr748Cys Single submitter ⚠
- p.Val308Ile Single submitter ⚠
- p.Val338Met Single submitter ⚠
- p.Val379Leu Single submitter ⚠
- p.Val411Ile Single submitter ⚠
- p.Val560Ala Single submitter ⚠
- p.Val560Met Single submitter ⚠
- p.Val655Ile Single submitter ⚠
- p.Val755Met Single submitter ⚠
- p.Val869Met Single submitter ⚠