ENKD1 — 65 ClinVar variants
All ClinVar germline ENKD1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 61 flagged for review →
3 Likely benign · 62 Uncertain significance
Full ENKD1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 61
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 51
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ENKD1 p.Ala167Val Uncertain significance Single submitter
- ENKD1 p.Ala29Gly Uncertain significance Single submitter
- ENKD1 p.Arg107Gln Uncertain significance Single submitter
- ENKD1 p.Arg114Cys Uncertain significance Single submitter
- ENKD1 p.Arg122Gln Uncertain significance Single submitter
- ENKD1 p.Arg135Cys Uncertain significance Single submitter
- ENKD1 p.Arg145Trp Uncertain significance Single submitter
- ENKD1 p.Arg166Trp Uncertain significance Single submitter
- ENKD1 p.Arg203His Uncertain significance Single submitter
- ENKD1 p.Arg263Cys Uncertain significance Single submitter
- ENKD1 p.Arg263His Uncertain significance Single submitter
- ENKD1 p.Arg263Leu Uncertain significance Single submitter
- ENKD1 p.Arg278His Uncertain significance Single submitter
- ENKD1 p.Arg300His Uncertain significance Single submitter
- ENKD1 p.Arg323Gln Uncertain significance Single submitter
- ENKD1 p.Arg94Ser Uncertain significance Single submitter
- ENKD1 p.Asp15Asn Uncertain significance Single submitter
- ENKD1 p.Asp50His Uncertain significance Single submitter
- ENKD1 p.Cys58Phe Uncertain significance Single submitter
- ENKD1 p.Gln126His Uncertain significance Single submitter
- ENKD1 p.Gln71Glu Uncertain significance Single submitter
- ENKD1 p.Gln80Arg Uncertain significance Single submitter
- ENKD1 p.Glu286Ala Uncertain significance Single submitter
- ENKD1 p.Glu65Lys Uncertain significance Single submitter
- ENKD1 p.Gly172Ser Uncertain significance Single submitter
- ENKD1 p.Gly174Asp Uncertain significance Single submitter
- ENKD1 p.Gly243Asp Uncertain significance Single submitter
- ENKD1 p.Gly308Glu Uncertain significance Single submitter
- ENKD1 p.Gly31Ala Uncertain significance Single submitter
- ENKD1 p.His236Leu Uncertain significance Single submitter
- ENKD1 p.Ile84Leu Uncertain significance Single submitter
- ENKD1 p.Leu175Phe Uncertain significance Single submitter
- ENKD1 p.Leu312Met Uncertain significance Single submitter
- ENKD1 p.Leu49Val Uncertain significance Single submitter
- ENKD1 p.Leu86Pro Uncertain significance Single submitter
- ENKD1 p.Leu92Ile Uncertain significance Single submitter
- ENKD1 p.Lys95Glu Uncertain significance Single submitter
- ENKD1 p.Pro137Arg Uncertain significance Single submitter
- ENKD1 p.Pro155His Uncertain significance Single submitter
- ENKD1 p.Pro177Leu Uncertain significance Single submitter
- ENKD1 p.Pro20Leu Uncertain significance Single submitter
- ENKD1 p.Ser6Pro Uncertain significance Single submitter
- ENKD1 p.Ser85Ala Uncertain significance Single submitter
- ENKD1 p.Thr277Lys Uncertain significance Single submitter
- ENKD1 p.Thr277Met Uncertain significance Single submitter
- ENKD1 p.Thr52Ile Uncertain significance Single submitter
- ENKD1 p.Val142Ala Uncertain significance Single submitter
- ENKD1 p.Val142Met Uncertain significance Single submitter
- ENKD1 p.Val226Met Uncertain significance Single submitter
- ENKD1 p.Val303Ile Uncertain significance Single submitter
- ENKD1 p.Val342Leu Uncertain significance Single submitter
Predictors split 10
The independent predictors disagree with each other — read with care.
- ENKD1 p.Arg203Pro Uncertain significance Single submitter
- ENKD1 p.Arg252Cys Uncertain significance Single submitter
- ENKD1 p.Arg258Trp Uncertain significance Single submitter
- ENKD1 p.Asn205Ser Uncertain significance Single submitter
- ENKD1 p.Phe164Leu Uncertain significance Single submitter
- ENKD1 p.Pro268Leu Uncertain significance Single submitter
- ENKD1 p.Pro280Ser Uncertain significance Single submitter
- ENKD1 p.Thr240Met Uncertain significance Single submitter
- ENKD1 p.Tyr237Asp Uncertain significance Single submitter
- ENKD1 p.Tyr23Asp Uncertain significance Single submitter
All ENKD1 variants
Likely benign 3
- p.Arg120His Single submitter
- p.Cys58Arg Single submitter
- p.Pro190= Single submitter
Uncertain significance 62
- p.Ala167Val Single submitter ⚠
- p.Ala29Gly Single submitter ⚠
- p.Arg107Gln Single submitter ⚠
- p.Arg114Cys Single submitter ⚠
- p.Arg122Gln Single submitter ⚠
- p.Arg135Cys Single submitter ⚠
- p.Arg145Trp Single submitter ⚠
- p.Arg166Trp Single submitter ⚠
- p.Arg203His Single submitter ⚠
- p.Arg203Pro Single submitter ⚠
- p.Arg252Cys Single submitter ⚠
- p.Arg258Trp Single submitter ⚠
- p.Arg263Cys Single submitter ⚠
- p.Arg263His Single submitter ⚠
- p.Arg263Leu Single submitter ⚠
- p.Arg278His Single submitter ⚠
- p.Arg300His Single submitter ⚠
- p.Arg323Gln Single submitter ⚠
- p.Arg94Ser Single submitter ⚠
- p.Asn205Ser Single submitter ⚠
- p.Asp15Asn Single submitter ⚠
- p.Asp50His Single submitter ⚠
- p.Cys58Phe Single submitter ⚠
- p.Gln126His Single submitter ⚠
- p.Gln71Glu Single submitter ⚠
- p.Gln80Arg Single submitter ⚠
- p.Glu286Ala Single submitter ⚠
- p.Glu65Lys Single submitter ⚠
- p.Gly172Ser Single submitter ⚠
- p.Gly174Asp Single submitter ⚠
- p.Gly243Asp Single submitter ⚠
- p.Gly308Glu Single submitter ⚠
- p.Gly31Ala Single submitter ⚠
- p.His236Leu Single submitter ⚠
- p.Ile84Leu Single submitter ⚠
- p.Leu175Phe Single submitter ⚠
- p.Leu312Met Single submitter ⚠
- p.Leu49Val Single submitter ⚠
- p.Leu86Pro Single submitter ⚠
- p.Leu92Ile Single submitter ⚠
- p.Lys95Glu Single submitter ⚠
- p.Phe164Leu Single submitter ⚠
- p.Pro137Arg Single submitter ⚠
- p.Pro155His Single submitter ⚠
- p.Pro177Leu Single submitter ⚠
- p.Pro20Leu Single submitter ⚠
- p.Pro268Leu Single submitter ⚠
- p.Pro280Ser Single submitter ⚠
- p.Ser6Pro Single submitter ⚠
- p.Ser85Ala Single submitter ⚠
- p.Thr240Met Single submitter ⚠
- p.Thr277Lys Single submitter ⚠
- p.Thr277Met Single submitter ⚠
- p.Thr52Ile Single submitter ⚠
- p.Tyr237Asp Single submitter ⚠
- p.Tyr23Asp Single submitter ⚠
- p.Val142Ala Single submitter ⚠
- p.Val142Met Single submitter ⚠
- p.Val226Met Single submitter ⚠
- p.Val303Ile Single submitter ⚠
- p.Val340Ile Single submitter
- p.Val342Leu Single submitter ⚠