ENO4 — 95 ClinVar variants
All ClinVar germline ENO4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 89 flagged for review →
1 Benign · 4 Likely benign · 90 Uncertain significance
Full ENO4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 89
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 70
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ENO4 p.Ala130Thr Uncertain significance Single submitter
- ENO4 p.Ala130Val Uncertain significance Single submitter
- ENO4 p.Ala166Thr Uncertain significance Single submitter
- ENO4 p.Ala248Pro Uncertain significance Single submitter
- ENO4 p.Ala421Val Uncertain significance Single submitter
- ENO4 p.Ala458Val Uncertain significance Single submitter
- ENO4 p.Ala593Val Uncertain significance Single submitter
- ENO4 p.Ala598Asp Uncertain significance Single submitter
- ENO4 p.Ala600Val Uncertain significance Single submitter
- ENO4 p.Arg14Thr Uncertain significance Single submitter
- ENO4 p.Arg542Gln Uncertain significance Single submitter
- ENO4 p.Arg8Cys Uncertain significance Single submitter
- ENO4 p.Asn114His Uncertain significance Single submitter
- ENO4 p.Asn295His Uncertain significance Single submitter
- ENO4 p.Asn325Asp Uncertain significance Single submitter
- ENO4 p.Asn382Ser Uncertain significance Single submitter
- ENO4 p.Asn571Ser Uncertain significance Single submitter
- ENO4 p.Asp158His Uncertain significance Single submitter
- ENO4 p.Asp172Asn Uncertain significance Single submitter
- ENO4 p.Asp215Ala Uncertain significance Single submitter
- ENO4 p.Asp50Glu Uncertain significance Single submitter
- ENO4 p.Asp530Asn Uncertain significance Single submitter
- ENO4 p.Gln22Arg Uncertain significance Single submitter
- ENO4 p.Glu15Ala Uncertain significance Single submitter
- ENO4 p.Glu219Gly Uncertain significance Single submitter
- ENO4 p.Glu229Gln Uncertain significance Single submitter
- ENO4 p.Glu229Lys Uncertain significance Single submitter
- ENO4 p.Glu25Lys Uncertain significance Single submitter
- ENO4 p.Glu315Lys Uncertain significance Single submitter
- ENO4 p.Glu38Lys Uncertain significance Single submitter
- ENO4 p.Glu38Val Uncertain significance Single submitter
- ENO4 p.Glu615Lys Uncertain significance Single submitter
- ENO4 p.Gly341Glu Uncertain significance Single submitter
- ENO4 p.Gly460Ala Uncertain significance Single submitter
- ENO4 p.Gly538Arg Uncertain significance Single submitter
- ENO4 p.Gly613Arg Uncertain significance Single submitter
- ENO4 p.Gly81Arg Uncertain significance Single submitter
- ENO4 p.His516Asp Uncertain significance Single submitter
- ENO4 p.Ile163Met Uncertain significance Single submitter
- ENO4 p.Ile324Met Uncertain significance Single submitter
- ENO4 p.Ile438Met Uncertain significance Single submitter
- ENO4 p.Ile511Thr Uncertain significance Single submitter
- ENO4 p.Ile517Met Uncertain significance Single submitter
- ENO4 p.Ile68Leu Uncertain significance Single submitter
- ENO4 p.Ile68Val Uncertain significance Single submitter
- ENO4 p.Leu178Ser Uncertain significance Single submitter
- ENO4 p.Leu535Met Uncertain significance Single submitter
- ENO4 p.Leu596Phe Uncertain significance Single submitter
- ENO4 p.Lys121Asn Uncertain significance Single submitter
- ENO4 p.Lys355Asn Uncertain significance Single submitter
- ENO4 p.Lys476Thr Uncertain significance Single submitter
- ENO4 p.Lys545Asn Uncertain significance Single submitter
- ENO4 p.Lys70Gln Uncertain significance Single submitter
- ENO4 p.Met236Thr Uncertain significance Single submitter
- ENO4 p.Met356Leu Uncertain significance Single submitter
- ENO4 p.Phe109Ser Uncertain significance Single submitter
- ENO4 p.Phe582Ser Uncertain significance Single submitter
- ENO4 p.Pro604Leu Uncertain significance Single submitter
- ENO4 p.Thr12Ile Uncertain significance Single submitter
- ENO4 p.Thr143Met Uncertain significance Single submitter
- ENO4 p.Thr218Ile Uncertain significance Single submitter
- ENO4 p.Thr353Ser Uncertain significance Single submitter
- ENO4 p.Thr363Ile Uncertain significance Single submitter
- ENO4 p.Thr556Asn Uncertain significance Single submitter
- ENO4 p.Tyr410His Uncertain significance Single submitter
- ENO4 p.Val241Leu Uncertain significance Single submitter
- ENO4 p.Val300Met Uncertain significance Single submitter
- ENO4 p.Val51Ala Uncertain significance Single submitter
- ENO4 p.Val72Met Uncertain significance Single submitter
- ENO4 p.Val76Ile Uncertain significance Single submitter
Predictors split 19
The independent predictors disagree with each other — read with care.
- ENO4 p.Arg560His Uncertain significance Single submitter
- ENO4 p.Asn559Ser Uncertain significance Single submitter
- ENO4 p.Glu118Lys Uncertain significance Single submitter
- ENO4 p.Gly148Arg Uncertain significance Single submitter
- ENO4 p.Gly234Ser Uncertain significance Single submitter
- ENO4 p.Gly239Glu Uncertain significance Single submitter
- ENO4 p.His54Gln Uncertain significance Single submitter
- ENO4 p.Ile238Thr Uncertain significance Single submitter
- ENO4 p.Ile303Met Uncertain significance Single submitter
- ENO4 p.Ile564Thr Uncertain significance Single submitter
- ENO4 p.Ile564Val Uncertain significance Single submitter
- ENO4 p.Ile71Thr Uncertain significance Single submitter
- ENO4 p.Leu561Phe Uncertain significance Single submitter
- ENO4 p.Met403Arg Uncertain significance Single submitter
- ENO4 p.Phe165Leu Uncertain significance Single submitter
- ENO4 p.Pro271Ser Uncertain significance Single submitter
- ENO4 p.Ser152Pro Uncertain significance Single submitter
- ENO4 p.Val424Ala Uncertain significance Single submitter
- ENO4 p.Val537Ala Uncertain significance Single submitter
All ENO4 variants
Benign 1
- p.Ile485= Single submitter
Likely benign 4
- p.Cys366Tyr Single submitter
- p.Glu619Lys Single submitter
- p.Ser140Gly Single submitter
- p.Val100Ile Single submitter
Uncertain significance 90
- p.Ala130Thr Single submitter ⚠
- p.Ala130Val Single submitter ⚠
- p.Ala166Thr Single submitter ⚠
- p.Ala248Pro Single submitter ⚠
- p.Ala421Val Single submitter ⚠
- p.Ala458Val Single submitter ⚠
- p.Ala593Val Single submitter ⚠
- p.Ala598Asp Single submitter ⚠
- p.Ala600Val Single submitter ⚠
- p.Arg14Thr Single submitter ⚠
- p.Arg542Gln Single submitter ⚠
- p.Arg560His Single submitter ⚠
- p.Arg8Cys Single submitter ⚠
- p.Asn114His Single submitter ⚠
- p.Asn295His Single submitter ⚠
- p.Asn325Asp Single submitter ⚠
- p.Asn382Ser Single submitter ⚠
- p.Asn559Ser Single submitter ⚠
- p.Asn571Ser Single submitter ⚠
- p.Asp158His Single submitter ⚠
- p.Asp172Asn Single submitter ⚠
- p.Asp215Ala Single submitter ⚠
- p.Asp50Glu Single submitter ⚠
- p.Asp530Asn Single submitter ⚠
- p.Gln22Arg Single submitter ⚠
- p.Glu118Lys Single submitter ⚠
- p.Glu15Ala Single submitter ⚠
- p.Glu219Gly Single submitter ⚠
- p.Glu229Gln Single submitter ⚠
- p.Glu229Lys Single submitter ⚠
- p.Glu25Lys Single submitter ⚠
- p.Glu315Lys Single submitter ⚠
- p.Glu38Lys Single submitter ⚠
- p.Glu38Val Single submitter ⚠
- p.Glu615Lys Single submitter ⚠
- p.Gly148Arg Single submitter ⚠
- p.Gly234Ser Single submitter ⚠
- p.Gly239Glu Single submitter ⚠
- p.Gly341Glu Single submitter ⚠
- p.Gly460Ala Single submitter ⚠
- p.Gly538Arg Single submitter ⚠
- p.Gly613Arg Single submitter ⚠
- p.Gly81Arg Single submitter ⚠
- p.His516Asp Single submitter ⚠
- p.His54Gln Single submitter ⚠
- p.Ile163Met Single submitter ⚠
- p.Ile238Thr Single submitter ⚠
- p.Ile303Met Single submitter ⚠
- p.Ile324Met Single submitter ⚠
- p.Ile438Met Single submitter ⚠
- p.Ile511Thr Single submitter ⚠
- p.Ile517Met Single submitter ⚠
- p.Ile564Thr Single submitter ⚠
- p.Ile564Val Single submitter ⚠
- p.Ile68Leu Single submitter ⚠
- p.Ile68Val Single submitter ⚠
- p.Ile71Thr Single submitter ⚠
- p.Leu178Ser Single submitter ⚠
- p.Leu39Arg Single submitter
- p.Leu535Met Single submitter ⚠
- p.Leu561Phe Single submitter ⚠
- p.Leu596Phe Single submitter ⚠
- p.Lys121Asn Single submitter ⚠
- p.Lys355Asn Single submitter ⚠
- p.Lys476Thr Single submitter ⚠
- p.Lys545Asn Single submitter ⚠
- p.Lys70Gln Single submitter ⚠
- p.Met236Thr Single submitter ⚠
- p.Met356Leu Single submitter ⚠
- p.Met403Arg Single submitter ⚠
- p.Phe109Ser Single submitter ⚠
- p.Phe165Leu Single submitter ⚠
- p.Phe582Ser Single submitter ⚠
- p.Pro271Ser Single submitter ⚠
- p.Pro604Leu Single submitter ⚠
- p.Ser152Pro Single submitter ⚠
- p.Thr12Ile Single submitter ⚠
- p.Thr143Met Single submitter ⚠
- p.Thr218Ile Single submitter ⚠
- p.Thr353Ser Single submitter ⚠
- p.Thr363Ile Single submitter ⚠
- p.Thr556Asn Single submitter ⚠
- p.Tyr410His Single submitter ⚠
- p.Val241Leu Single submitter ⚠
- p.Val300Met Single submitter ⚠
- p.Val424Ala Single submitter ⚠
- p.Val51Ala Single submitter ⚠
- p.Val537Ala Single submitter ⚠
- p.Val72Met Single submitter ⚠
- p.Val76Ile Single submitter ⚠