ENOX1 — 83 ClinVar variants
All ClinVar germline ENOX1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 78 flagged for review →
2 Likely benign · 81 Uncertain significance
Full ENOX1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 78
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 59
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ENOX1 p.Ala428Thr Uncertain significance Single submitter
- ENOX1 p.Ala510Val Uncertain significance Single submitter
- ENOX1 p.Arg172Gln Uncertain significance Single submitter
- ENOX1 p.Arg199Gly Uncertain significance Single submitter
- ENOX1 p.Arg233Thr Uncertain significance Single submitter
- ENOX1 p.Arg237Pro Uncertain significance Single submitter
- ENOX1 p.Arg242Gln Uncertain significance Single submitter
- ENOX1 p.Arg316Pro Uncertain significance Single submitter
- ENOX1 p.Arg395Pro Uncertain significance Single submitter
- ENOX1 p.Arg396His Uncertain significance Single submitter
- ENOX1 p.Arg551Gln Uncertain significance Single submitter
- ENOX1 p.Arg615Cys Uncertain significance Single submitter
- ENOX1 p.Asn39Asp Uncertain significance Single submitter
- ENOX1 p.Asn540Ser Uncertain significance Single submitter
- ENOX1 p.Asn604Tyr Uncertain significance Single submitter
- ENOX1 p.Asp34Glu Uncertain significance Single submitter
- ENOX1 p.Asp467Asn Uncertain significance Single submitter
- ENOX1 p.Cys165Ser Uncertain significance Single submitter
- ENOX1 p.Cys230Gly Uncertain significance Single submitter
- ENOX1 p.Gln12Lys Uncertain significance Single submitter
- ENOX1 p.Gln425Arg Uncertain significance Single submitter
- ENOX1 p.Gln456Glu Uncertain significance Single submitter
- ENOX1 p.Gln468His Uncertain significance Single submitter
- ENOX1 p.Gln482Glu Uncertain significance Single submitter
- ENOX1 p.Glu160Lys Uncertain significance Single submitter
- ENOX1 p.Glu461Gly Uncertain significance Single submitter
- ENOX1 p.Glu8Gly Uncertain significance Single submitter
- ENOX1 p.Gly147Arg Uncertain significance Single submitter
- ENOX1 p.Gly197Val Uncertain significance Single submitter
- ENOX1 p.Gly572Val Uncertain significance Single submitter
- ENOX1 p.His324Arg Uncertain significance Single submitter
- ENOX1 p.Ile10Val Uncertain significance Single submitter
- ENOX1 p.Ile31Val Uncertain significance Single submitter
- ENOX1 p.Ile33Val Uncertain significance Single submitter
- ENOX1 p.Ile640Val Uncertain significance Single submitter
- ENOX1 p.Leu13Val Uncertain significance Single submitter
- ENOX1 p.Leu38Ile Uncertain significance Single submitter
- ENOX1 p.Lys600Arg Uncertain significance Single submitter
- ENOX1 p.Lys618Arg Uncertain significance Single submitter
- ENOX1 p.Met200Lys Uncertain significance Single submitter
- ENOX1 p.Phe617Leu Uncertain significance Single submitter
- ENOX1 p.Pro105Leu Uncertain significance Single submitter
- ENOX1 p.Pro131Ala Uncertain significance Single submitter
- ENOX1 p.Ser410Gly Uncertain significance Single submitter
- ENOX1 p.Ser506Cys Uncertain significance Single submitter
- ENOX1 p.Ser559Asn Uncertain significance Single submitter
- ENOX1 p.Thr106Ala Uncertain significance Single submitter
- ENOX1 p.Thr627Met Uncertain significance Single submitter
- ENOX1 p.Trp289Ser Uncertain significance Single submitter
- ENOX1 p.Tyr427His Uncertain significance Single submitter
- ENOX1 p.Val111Ile Uncertain significance Single submitter
- ENOX1 p.Val417Ile Uncertain significance Single submitter
- ENOX1 p.Val42Met Uncertain significance Single submitter
- ENOX1 p.Val541Met Uncertain significance Single submitter
- ENOX1 p.Val580Ile Uncertain significance Single submitter
- ENOX1 p.Val60Ala Uncertain significance Single submitter
- ENOX1 p.Val60Ile Uncertain significance Single submitter
- ENOX1 p.Val60Leu Uncertain significance Single submitter
- ENOX1 p.Val68Met Uncertain significance Single submitter
Predictors split 19
The independent predictors disagree with each other — read with care.
- ENOX1 p.Ala236Ser Uncertain significance Single submitter
- ENOX1 p.Ala257Asp Uncertain significance Single submitter
- ENOX1 p.Ala442Val Uncertain significance Single submitter
- ENOX1 p.Arg237Trp Uncertain significance Single submitter
- ENOX1 p.Arg240Gln Uncertain significance Single submitter
- ENOX1 p.Arg243Gly Uncertain significance Single submitter
- ENOX1 p.Arg249Trp Uncertain significance Single submitter
- ENOX1 p.Asp207Asn Uncertain significance Single submitter
- ENOX1 p.Asp248Tyr Uncertain significance Single submitter
- ENOX1 p.Cys117Arg Uncertain significance Single submitter
- ENOX1 p.Cys635Arg Uncertain significance Single submitter
- ENOX1 p.Glu490Gly Uncertain significance Single submitter
- ENOX1 p.Gly479Arg Uncertain significance Single submitter
- ENOX1 p.Met594Thr Uncertain significance Single submitter
- ENOX1 p.Phe335Leu Uncertain significance Single submitter
- ENOX1 p.Pro253Gln Uncertain significance Single submitter
- ENOX1 p.Ser309Leu Uncertain significance Single submitter
- ENOX1 p.Ser602Pro Uncertain significance Single submitter
- ENOX1 p.Thr476Ile Uncertain significance Single submitter
All ENOX1 variants
Likely benign 2
- p.Gln66Arg Single submitter
- p.Val624= Single submitter
Uncertain significance 81
- c.1143+2T>C Single submitter
- p.Ala236Ser Single submitter ⚠
- p.Ala257Asp Single submitter ⚠
- p.Ala428Thr Single submitter ⚠
- p.Ala442Val Single submitter ⚠
- p.Ala510Val Single submitter ⚠
- p.Arg172Gln Single submitter ⚠
- p.Arg199Gly Single submitter ⚠
- p.Arg233Thr Single submitter ⚠
- p.Arg237Pro Single submitter ⚠
- p.Arg237Trp Single submitter ⚠
- p.Arg240Gln Single submitter ⚠
- p.Arg242Gln Single submitter ⚠
- p.Arg243Gly Single submitter ⚠
- p.Arg249Trp Single submitter ⚠
- p.Arg316Pro Single submitter ⚠
- p.Arg395Pro Single submitter ⚠
- p.Arg396His Single submitter ⚠
- p.Arg551Gln Single submitter ⚠
- p.Arg615Cys Single submitter ⚠
- p.Asn39Asp Single submitter ⚠
- p.Asn540Ser Single submitter ⚠
- p.Asn604Tyr Single submitter ⚠
- p.Asp207Asn Single submitter ⚠
- p.Asp248Tyr Single submitter ⚠
- p.Asp34Glu Single submitter ⚠
- p.Asp467Asn Single submitter ⚠
- p.Cys117Arg Single submitter ⚠
- p.Cys165Ser Single submitter ⚠
- p.Cys230Gly Single submitter ⚠
- p.Cys635Arg Single submitter ⚠
- p.Gln12Lys Single submitter ⚠
- p.Gln425Arg Single submitter ⚠
- p.Gln456Glu Single submitter ⚠
- p.Gln468His Single submitter ⚠
- p.Gln482Glu Single submitter ⚠
- p.Glu160Lys Single submitter ⚠
- p.Glu461Gly Single submitter ⚠
- p.Glu490Gly Single submitter ⚠
- p.Glu8Gly Single submitter ⚠
- p.Gly147Arg Single submitter ⚠
- p.Gly197Val Single submitter ⚠
- p.Gly479Arg Single submitter ⚠
- p.Gly572Val Single submitter ⚠
- p.His324Arg Single submitter ⚠
- p.Ile10Val Single submitter ⚠
- p.Ile31Val Single submitter ⚠
- p.Ile33Val Single submitter ⚠
- p.Ile640Val Single submitter ⚠
- p.Leu13Val Single submitter ⚠
- p.Leu38Ile Single submitter ⚠
- p.Lys600Arg Single submitter ⚠
- p.Lys618Arg Single submitter ⚠
- p.Met200Lys Single submitter ⚠
- p.Met594Thr Single submitter ⚠
- p.Phe335Leu Single submitter ⚠
- p.Phe617Leu Single submitter ⚠
- p.Pro105Leu Single submitter ⚠
- p.Pro131Ala Single submitter ⚠
- p.Pro253Gln Single submitter ⚠
- p.Pro59Ser Single submitter
- p.Ser309Leu Single submitter ⚠
- p.Ser410Gly Single submitter ⚠
- p.Ser506Cys Single submitter ⚠
- p.Ser559Asn Single submitter ⚠
- p.Ser602Pro Single submitter ⚠
- p.Thr106Ala Single submitter ⚠
- p.Thr476Ile Single submitter ⚠
- p.Thr627Met Single submitter ⚠
- p.Trp289Ser Single submitter ⚠
- p.Tyr427His Single submitter ⚠
- p.Val111Ile Single submitter ⚠
- p.Val417Ile Single submitter ⚠
- p.Val42Met Single submitter ⚠
- p.Val541Met Single submitter ⚠
- p.Val580Ile Single submitter ⚠
- p.Val60Ala Single submitter ⚠
- p.Val60Ile Single submitter ⚠
- p.Val60Leu Single submitter ⚠
- p.Val68Met Single submitter ⚠
- p.Ser254fs No assertion criteria prostate cancer