ENPP7 — 103 ClinVar variants
All ClinVar germline ENPP7 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 94 flagged for review →
15 Likely benign · 88 Uncertain significance
Full ENPP7 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 94
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 36
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ENPP7 p.Ala322Thr Uncertain significance Single submitter
- ENPP7 p.Ala368Thr Uncertain significance Single submitter
- ENPP7 p.Ala407Pro Uncertain significance Single submitter
- ENPP7 p.Ala458Thr Uncertain significance Single submitter
- ENPP7 p.Ala5Val Uncertain significance Single submitter
- ENPP7 p.Arg173Lys Uncertain significance Single submitter
- ENPP7 p.Arg212Gly Uncertain significance Single submitter
- ENPP7 p.Arg393Gln Uncertain significance Single submitter
- ENPP7 p.Asp246Asn Uncertain significance Single submitter
- ENPP7 p.Asp258Asn Uncertain significance Single submitter
- ENPP7 p.Asp46His Uncertain significance Single submitter
- ENPP7 p.Glu185Gln Uncertain significance Single submitter
- ENPP7 p.Glu416Asp Uncertain significance Single submitter
- ENPP7 p.Gly19Ala Uncertain significance Single submitter
- ENPP7 p.Gly248Cys Uncertain significance Single submitter
- ENPP7 p.Gly248Ser Uncertain significance Single submitter
- ENPP7 p.Gly28Ser Uncertain significance Single submitter
- ENPP7 p.Gly354Ser Uncertain significance Single submitter
- ENPP7 p.Gly40Arg Uncertain significance Single submitter
- ENPP7 p.His353Gln Uncertain significance Single submitter
- ENPP7 p.Leu188Arg Uncertain significance Single submitter
- ENPP7 p.Leu188Met Uncertain significance Single submitter
- ENPP7 p.Leu193Phe Uncertain significance Single submitter
- ENPP7 p.Leu226His Uncertain significance Single submitter
- ENPP7 p.Leu278Pro Uncertain significance Single submitter
- ENPP7 p.Lys104Asn Uncertain significance Single submitter
- ENPP7 p.Lys311Arg Uncertain significance Single submitter
- ENPP7 p.Lys430Arg Uncertain significance Single submitter
- ENPP7 p.Lys430Glu Uncertain significance Single submitter
- ENPP7 p.Pro282Leu Uncertain significance Single submitter
- ENPP7 p.Ser209Pro Uncertain significance Single submitter
- ENPP7 p.Ser438Arg Uncertain significance Single submitter
- ENPP7 p.Tyr98Asn Uncertain significance Single submitter
- ENPP7 p.Val219Glu Uncertain significance Single submitter
- ENPP7 p.Val219Met Uncertain significance Single submitter
- ENPP7 p.Val223Leu Uncertain significance Single submitter
Predictors split 58
The independent predictors disagree with each other — read with care.
- ENPP7 p.Ala174Val Uncertain significance Single submitter
- ENPP7 p.Ala231Thr Uncertain significance Single submitter
- ENPP7 p.Arg156Gln Uncertain significance Single submitter
- ENPP7 p.Arg156Trp Uncertain significance Single submitter
- ENPP7 p.Arg204Ser Uncertain significance Single submitter
- ENPP7 p.Arg217Trp Uncertain significance Single submitter
- ENPP7 p.Arg221Gln Uncertain significance Single submitter
- ENPP7 p.Arg221Trp Uncertain significance Single submitter
- ENPP7 p.Arg227Trp Uncertain significance Single submitter
- ENPP7 p.Arg232Cys Uncertain significance Single submitter
- ENPP7 p.Arg232Leu Uncertain significance Single submitter
- ENPP7 p.Arg271Trp Uncertain significance Single submitter
- ENPP7 p.Arg367Cys Uncertain significance Single submitter
- ENPP7 p.Arg374Gly Uncertain significance Single submitter
- ENPP7 p.Arg393Trp Likely benign Single submitter
- ENPP7 p.Arg42His Uncertain significance Single submitter
- ENPP7 p.Arg59Gln Likely benign Single submitter
- ENPP7 p.Arg65His Uncertain significance Single submitter
- ENPP7 p.Asn240Asp Uncertain significance Single submitter
- ENPP7 p.Asp237Asn Uncertain significance Single submitter
- ENPP7 p.Asp335Asn Uncertain significance Single submitter
- ENPP7 p.Asp335Glu Uncertain significance Single submitter
- ENPP7 p.Asp403Asn Uncertain significance Single submitter
- ENPP7 p.Gln347Arg Uncertain significance Single submitter
- ENPP7 p.Glu274Lys Likely benign Single submitter
- ENPP7 p.Glu389Lys Uncertain significance Single submitter
- ENPP7 p.Gly122Ser Uncertain significance Single submitter
- ENPP7 p.Gly151Glu Uncertain significance Single submitter
- ENPP7 p.Gly19Trp Uncertain significance Single submitter
- ENPP7 p.Gly21Arg Uncertain significance Single submitter
- ENPP7 p.Gly396Asp Uncertain significance Single submitter
- ENPP7 p.His386Arg Uncertain significance Single submitter
- ENPP7 p.Ile176Thr Uncertain significance Single submitter
- ENPP7 p.Leu406Pro Likely benign Single submitter
- ENPP7 p.Lys311Gln Uncertain significance Single submitter
- ENPP7 p.Met332Ile Uncertain significance Single submitter
- ENPP7 p.Met391Ile Uncertain significance Single submitter
- ENPP7 p.Met67Leu Uncertain significance Single submitter
- ENPP7 p.Met67Val Uncertain significance Single submitter
- ENPP7 p.Phe319Leu Likely benign Single submitter
- ENPP7 p.Pro316Thr Uncertain significance Single submitter
- ENPP7 p.Pro325His Uncertain significance Single submitter
- ENPP7 p.Ser417Phe Uncertain significance Single submitter
- ENPP7 p.Thr14Met Uncertain significance Single submitter
- ENPP7 p.Thr155Met Uncertain significance Single submitter
- ENPP7 p.Thr170Met Uncertain significance Single submitter
- ENPP7 p.Thr178Ile Uncertain significance Single submitter
- ENPP7 p.Thr222Ile Uncertain significance Single submitter
- ENPP7 p.Thr250Met Uncertain significance Single submitter
- ENPP7 p.Thr426Ile Uncertain significance Single submitter
- ENPP7 p.Tyr333Cys Uncertain significance Single submitter
- ENPP7 p.Val124Met Uncertain significance Single submitter
- ENPP7 p.Val219Leu Uncertain significance Single submitter
- ENPP7 p.Val387Met Uncertain significance Single submitter
- ENPP7 p.Val444Met Uncertain significance Single submitter
- ENPP7 p.Val451Met Likely benign Single submitter
- ENPP7 p.Val49Met Uncertain significance Single submitter
-
ENPP7 p.Pro23Leu
Uncertain significance
No assertion criteria
prostate cancer
All ENPP7 variants
Likely benign 15
- p.Ala111Thr Single submitter
- p.Arg255Gln Single submitter
- p.Arg271Gln Single submitter
- p.Arg367= Single submitter
- p.Arg393Trp Single submitter ⚠
- p.Arg59Gln Single submitter ⚠
- p.Asn121= Single submitter
- p.Glu228Asp Single submitter
- p.Glu274Lys Single submitter ⚠
- p.Ile176Val Single submitter
- p.Leu336Pro Single submitter
- p.Leu406Pro Single submitter ⚠
- p.Phe319Leu Single submitter ⚠
- p.Pro420Leu Single submitter
- p.Val451Met Single submitter ⚠
Uncertain significance 88
- p.Ala174Val Single submitter ⚠
- p.Ala231Thr Single submitter ⚠
- p.Ala322Thr Single submitter ⚠
- p.Ala368Thr Single submitter ⚠
- p.Ala407Pro Single submitter ⚠
- p.Ala458Thr Single submitter ⚠
- p.Ala5Val Single submitter ⚠
- p.Arg156Gln Single submitter ⚠
- p.Arg156Trp Single submitter ⚠
- p.Arg173Lys Single submitter ⚠
- p.Arg204Ser Single submitter ⚠
- p.Arg212Gly Single submitter ⚠
- p.Arg217Trp Single submitter ⚠
- p.Arg221Gln Single submitter ⚠
- p.Arg221Trp Single submitter ⚠
- p.Arg227Trp Single submitter ⚠
- p.Arg232Cys Single submitter ⚠
- p.Arg232Leu Single submitter ⚠
- p.Arg271Trp Single submitter ⚠
- p.Arg367Cys Single submitter ⚠
- p.Arg374Gly Single submitter ⚠
- p.Arg393Gln Single submitter ⚠
- p.Arg42His Single submitter ⚠
- p.Arg65His Single submitter ⚠
- p.Asn240Asp Single submitter ⚠
- p.Asp237Asn Single submitter ⚠
- p.Asp246Asn Single submitter ⚠
- p.Asp258Asn Single submitter ⚠
- p.Asp335Asn Single submitter ⚠
- p.Asp335Glu Single submitter ⚠
- p.Asp403Asn Single submitter ⚠
- p.Asp46His Single submitter ⚠
- p.Gln347Arg Single submitter ⚠
- p.Glu185Gln Single submitter ⚠
- p.Glu389Lys Single submitter ⚠
- p.Glu416Asp Single submitter ⚠
- p.Gly122Ser Single submitter ⚠
- p.Gly151Glu Single submitter ⚠
- p.Gly19Ala Single submitter ⚠
- p.Gly19Trp Single submitter ⚠
- p.Gly21Arg Single submitter ⚠
- p.Gly248Cys Single submitter ⚠
- p.Gly248Ser Single submitter ⚠
- p.Gly28Ser Single submitter ⚠
- p.Gly354Ser Single submitter ⚠
- p.Gly396Asp Single submitter ⚠
- p.Gly40Arg Single submitter ⚠
- p.His353Gln Single submitter ⚠
- p.His386Arg Single submitter ⚠
- p.Ile176Thr Single submitter ⚠
- p.Leu188Arg Single submitter ⚠
- p.Leu188Met Single submitter ⚠
- p.Leu193Phe Single submitter ⚠
- p.Leu226His Single submitter ⚠
- p.Leu278Pro Single submitter ⚠
- p.Lys104Asn Single submitter ⚠
- p.Lys311Arg Single submitter ⚠
- p.Lys311Gln Single submitter ⚠
- p.Lys430Arg Single submitter ⚠
- p.Lys430Glu Single submitter ⚠
- p.Met332Ile Single submitter ⚠
- p.Met391Ile Single submitter ⚠
- p.Met67Leu Single submitter ⚠
- p.Met67Val Single submitter ⚠
- p.Pro282Leu Single submitter ⚠
- p.Pro316Thr Single submitter ⚠
- p.Pro325His Single submitter ⚠
- p.Ser209Pro Single submitter ⚠
- p.Ser417Phe Single submitter ⚠
- p.Ser438Arg Single submitter ⚠
- p.Thr14Met Single submitter ⚠
- p.Thr155Met Single submitter ⚠
- p.Thr170Met Single submitter ⚠
- p.Thr178Ile Single submitter ⚠
- p.Thr222Ile Single submitter ⚠
- p.Thr250Met Single submitter ⚠
- p.Thr426Ile Single submitter ⚠
- p.Tyr333Cys Single submitter ⚠
- p.Tyr98Asn Single submitter ⚠
- p.Val124Met Single submitter ⚠
- p.Val219Glu Single submitter ⚠
- p.Val219Leu Single submitter ⚠
- p.Val219Met Single submitter ⚠
- p.Val223Leu Single submitter ⚠
- p.Val387Met Single submitter ⚠
- p.Val444Met Single submitter ⚠
- p.Val49Met Single submitter ⚠
- p.Pro23Leu No assertion criteria prostate cancer ⚠