ENTPD3 — 72 ClinVar variants
All ClinVar germline ENTPD3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 68 flagged for review →
4 Likely benign · 68 Uncertain significance
Full ENTPD3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 68
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 41
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ENTPD3 p.Ala140Val Uncertain significance Single submitter
- ENTPD3 p.Ala17Ser Uncertain significance Single submitter
- ENTPD3 p.Ala223Val Uncertain significance Single submitter
- ENTPD3 p.Ala492Thr Uncertain significance Single submitter
- ENTPD3 p.Arg143His Uncertain significance Single submitter
- ENTPD3 p.Arg292Gln Uncertain significance Single submitter
- ENTPD3 p.Arg419His Uncertain significance Single submitter
- ENTPD3 p.Arg479His Uncertain significance Single submitter
- ENTPD3 p.Arg7Cys Uncertain significance Single submitter
- ENTPD3 p.Asn191Lys Uncertain significance Single submitter
- ENTPD3 p.Asn287Asp Uncertain significance Single submitter
- ENTPD3 p.Cys116Tyr Uncertain significance Single submitter
- ENTPD3 p.Glu155Lys Uncertain significance Single submitter
- ENTPD3 p.Glu233Lys Uncertain significance Single submitter
- ENTPD3 p.Glu315Asp Uncertain significance Single submitter
- ENTPD3 p.Glu519Lys Uncertain significance Single submitter
- ENTPD3 p.Gly122Arg Uncertain significance Single submitter
- ENTPD3 p.Gly130Arg Uncertain significance Single submitter
- ENTPD3 p.Gly179Glu Uncertain significance Single submitter
- ENTPD3 p.Gly221Arg Uncertain significance Single submitter
- ENTPD3 p.Gly222Asp Uncertain significance Single submitter
- ENTPD3 p.Gly329Trp Uncertain significance Single submitter
- ENTPD3 p.Gly435Cys Uncertain significance Single submitter
- ENTPD3 p.His284Arg Uncertain significance Single submitter
- ENTPD3 p.His302Arg Uncertain significance Single submitter
- ENTPD3 p.Ile43Phe Uncertain significance Single submitter
- ENTPD3 p.Leu136Pro Uncertain significance Single submitter
- ENTPD3 p.Lys515Asn Uncertain significance Single submitter
- ENTPD3 p.Met205Ile Uncertain significance Single submitter
- ENTPD3 p.Phe367Leu Uncertain significance Single submitter
- ENTPD3 p.Phe438Leu Uncertain significance Single submitter
- ENTPD3 p.Pro366Arg Uncertain significance Single submitter
- ENTPD3 p.Pro53Ala Uncertain significance Single submitter
- ENTPD3 p.Pro9Leu Uncertain significance Single submitter
- ENTPD3 p.Ser466Gly Uncertain significance Single submitter
- ENTPD3 p.Thr139Met Uncertain significance Single submitter
- ENTPD3 p.Thr376Lys Uncertain significance Single submitter
- ENTPD3 p.Thr68Ala Uncertain significance Single submitter
- ENTPD3 p.Thr68Ile Uncertain significance Single submitter
- ENTPD3 p.Val452Met Uncertain significance Single submitter
-
ENTPD3 p.Phe271Tyr
Uncertain significance
No assertion criteria
prostate cancer
Predictors split 27
The independent predictors disagree with each other — read with care.
- ENTPD3 p.Arg292Trp Uncertain significance Single submitter
- ENTPD3 p.Arg419Cys Uncertain significance Single submitter
- ENTPD3 p.Arg513Lys Uncertain significance Single submitter
- ENTPD3 p.Glu315Gly Uncertain significance Single submitter
- ENTPD3 p.His135Asp Uncertain significance Single submitter
- ENTPD3 p.His135Pro Uncertain significance Single submitter
- ENTPD3 p.Ile25Met Uncertain significance Single submitter
- ENTPD3 p.Ile428Asn Uncertain significance Single submitter
- ENTPD3 p.Leu27Trp Uncertain significance Single submitter
- ENTPD3 p.Leu285Pro Uncertain significance Single submitter
- ENTPD3 p.Leu37Phe Uncertain significance Single submitter
- ENTPD3 p.Leu382Phe Uncertain significance Single submitter
- ENTPD3 p.Leu408Pro Uncertain significance Single submitter
- ENTPD3 p.Lys364Asn Uncertain significance Single submitter
- ENTPD3 p.Lys437Glu Uncertain significance Single submitter
- ENTPD3 p.Met194Ile Uncertain significance Single submitter
- ENTPD3 p.Met464Leu Uncertain significance Single submitter
- ENTPD3 p.Met464Thr Uncertain significance Single submitter
- ENTPD3 p.Phe344Cys Uncertain significance Single submitter
- ENTPD3 p.Phe423Leu Uncertain significance Single submitter
- ENTPD3 p.Ser101Thr Uncertain significance Single submitter
- ENTPD3 p.Thr253Met Uncertain significance Single submitter
- ENTPD3 p.Trp206Gly Uncertain significance Single submitter
- ENTPD3 p.Trp206Leu Uncertain significance Single submitter
- ENTPD3 p.Trp396Cys Uncertain significance Single submitter
- ENTPD3 p.Val207Ala Uncertain significance Single submitter
- ENTPD3 p.Val310Gly Uncertain significance Single submitter
All ENTPD3 variants
Likely benign 4
- p.Ala496= Single submitter
- p.Arg264Gln Single submitter
- p.Thr139= Single submitter
- p.Val488Met Single submitter
Uncertain significance 68
- p.Ala140Val Single submitter ⚠
- p.Ala17Ser Single submitter ⚠
- p.Ala223Val Single submitter ⚠
- p.Ala492Thr Single submitter ⚠
- p.Arg143His Single submitter ⚠
- p.Arg292Gln Single submitter ⚠
- p.Arg292Trp Single submitter ⚠
- p.Arg419Cys Single submitter ⚠
- p.Arg419His Single submitter ⚠
- p.Arg479His Single submitter ⚠
- p.Arg513Lys Single submitter ⚠
- p.Arg7Cys Single submitter ⚠
- p.Asn191Lys Single submitter ⚠
- p.Asn287Asp Single submitter ⚠
- p.Cys116Tyr Single submitter ⚠
- p.Glu155Lys Single submitter ⚠
- p.Glu233Lys Single submitter ⚠
- p.Glu315Asp Single submitter ⚠
- p.Glu315Gly Single submitter ⚠
- p.Glu519Lys Single submitter ⚠
- p.Gly122Arg Single submitter ⚠
- p.Gly130Arg Single submitter ⚠
- p.Gly179Glu Single submitter ⚠
- p.Gly221Arg Single submitter ⚠
- p.Gly222Asp Single submitter ⚠
- p.Gly329Trp Single submitter ⚠
- p.Gly435Cys Single submitter ⚠
- p.His135Asp Single submitter ⚠
- p.His135Pro Single submitter ⚠
- p.His284Arg Single submitter ⚠
- p.His302Arg Single submitter ⚠
- p.Ile25Met Single submitter ⚠
- p.Ile428Asn Single submitter ⚠
- p.Ile43Phe Single submitter ⚠
- p.Leu136Pro Single submitter ⚠
- p.Leu27Trp Single submitter ⚠
- p.Leu285Pro Single submitter ⚠
- p.Leu37Phe Single submitter ⚠
- p.Leu382Phe Single submitter ⚠
- p.Leu408Pro Single submitter ⚠
- p.Lys364Asn Single submitter ⚠
- p.Lys437Glu Single submitter ⚠
- p.Lys515Asn Single submitter ⚠
- p.Met194Ile Single submitter ⚠
- p.Met205Ile Single submitter ⚠
- p.Met464Leu Single submitter ⚠
- p.Met464Thr Single submitter ⚠
- p.Phe344Cys Single submitter ⚠
- p.Phe367Leu Single submitter ⚠
- p.Phe423Leu Single submitter ⚠
- p.Phe438Leu Single submitter ⚠
- p.Pro366Arg Single submitter ⚠
- p.Pro53Ala Single submitter ⚠
- p.Pro9Leu Single submitter ⚠
- p.Ser101Thr Single submitter ⚠
- p.Ser466Gly Single submitter ⚠
- p.Thr139Met Single submitter ⚠
- p.Thr253Met Single submitter ⚠
- p.Thr376Lys Single submitter ⚠
- p.Thr68Ala Single submitter ⚠
- p.Thr68Ile Single submitter ⚠
- p.Trp206Gly Single submitter ⚠
- p.Trp206Leu Single submitter ⚠
- p.Trp396Cys Single submitter ⚠
- p.Val207Ala Single submitter ⚠
- p.Val310Gly Single submitter ⚠
- p.Val452Met Single submitter ⚠
- p.Phe271Tyr No assertion criteria prostate cancer ⚠