ENTPD4 — 111 ClinVar variants
All ClinVar germline ENTPD4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 107 flagged for review →
6 Likely benign · 105 Uncertain significance
Full ENTPD4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 107
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 74
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ENTPD4 p.Ala167Glu Uncertain significance Single submitter
- ENTPD4 p.Ala246Gly Uncertain significance Single submitter
- ENTPD4 p.Ala267Val Uncertain significance Single submitter
- ENTPD4 p.Ala280Val Uncertain significance Single submitter
- ENTPD4 p.Ala478Thr Uncertain significance Single submitter
- ENTPD4 p.Ala547Val Uncertain significance Single submitter
- ENTPD4 p.Ala599Thr Uncertain significance Single submitter
- ENTPD4 p.Arg109Ser Uncertain significance Single submitter
- ENTPD4 p.Arg166Gly Uncertain significance Single submitter
- ENTPD4 p.Arg469Gln Uncertain significance Single submitter
- ENTPD4 p.Arg471Leu Uncertain significance Single submitter
- ENTPD4 p.Arg474Gln Uncertain significance Single submitter
- ENTPD4 p.Arg485Gly Uncertain significance Single submitter
- ENTPD4 p.Arg536Cys Uncertain significance Single submitter
- ENTPD4 p.Arg549Gln Uncertain significance Single submitter
- ENTPD4 p.Arg587His Uncertain significance Single submitter
- ENTPD4 p.Arg594Gly Uncertain significance Single submitter
- ENTPD4 p.Asn111Asp Uncertain significance Single submitter
- ENTPD4 p.Asn113Ser Uncertain significance Single submitter
- ENTPD4 p.Asn251Ile Uncertain significance Single submitter
- ENTPD4 p.Asn349Ser Uncertain significance Single submitter
- ENTPD4 p.Asn509Ser Uncertain significance Single submitter
- ENTPD4 p.Asn86Asp Uncertain significance Single submitter
- ENTPD4 p.Asp125Gly Uncertain significance Single submitter
- ENTPD4 p.Asp310Gly Uncertain significance Single submitter
- ENTPD4 p.Cys570Trp Uncertain significance Single submitter
- ENTPD4 p.Gln544Glu Uncertain significance Single submitter
- ENTPD4 p.Glu141Ala Uncertain significance Single submitter
- ENTPD4 p.Glu238Asp Uncertain significance Single submitter
- ENTPD4 p.Glu238Gly Uncertain significance Single submitter
- ENTPD4 p.Glu259Lys Uncertain significance Single submitter
- ENTPD4 p.Glu282Asp Uncertain significance Single submitter
- ENTPD4 p.Glu439Lys Uncertain significance Single submitter
- ENTPD4 p.Gly22Glu Uncertain significance Single submitter
- ENTPD4 p.Gly235Glu Uncertain significance Single submitter
- ENTPD4 p.Gly329Asp Uncertain significance Single submitter
- ENTPD4 p.Gly329Ser Uncertain significance Single submitter
- ENTPD4 p.Gly430Ser Uncertain significance Single submitter
- ENTPD4 p.His480Arg Uncertain significance Single submitter
- ENTPD4 p.His480Leu Uncertain significance Single submitter
- ENTPD4 p.His552Leu Uncertain significance Single submitter
- ENTPD4 p.Ile217Met Uncertain significance Single submitter
- ENTPD4 p.Ile230Thr Uncertain significance Single submitter
- ENTPD4 p.Ile4Thr Uncertain significance Single submitter
- ENTPD4 p.Leu486Phe Uncertain significance Single submitter
- ENTPD4 p.Leu71Arg Uncertain significance Single submitter
- ENTPD4 p.Lys168Glu Uncertain significance Single submitter
- ENTPD4 p.Met444Ile Uncertain significance Single submitter
- ENTPD4 p.Met496Val Uncertain significance Single submitter
- ENTPD4 p.Phe237Leu Uncertain significance Single submitter
- ENTPD4 p.Phe434Leu Uncertain significance Single submitter
- ENTPD4 p.Phe560Ile Uncertain significance Single submitter
- ENTPD4 p.Pro137Arg Uncertain significance Single submitter
- ENTPD4 p.Pro137Ser Uncertain significance Single submitter
- ENTPD4 p.Pro20Ala Uncertain significance Single submitter
- ENTPD4 p.Pro20Ser Uncertain significance Single submitter
- ENTPD4 p.Pro363Gln Uncertain significance Single submitter
- ENTPD4 p.Pro539Leu Uncertain significance Single submitter
- ENTPD4 p.Pro593Thr Uncertain significance Single submitter
- ENTPD4 p.Pro608Thr Uncertain significance Single submitter
- ENTPD4 p.Pro613Leu Uncertain significance Single submitter
- ENTPD4 p.Ser17Cys Uncertain significance Single submitter
- ENTPD4 p.Ser276Leu Uncertain significance Single submitter
- ENTPD4 p.Thr62Ile Uncertain significance Single submitter
- ENTPD4 p.Tyr175Asn Uncertain significance Single submitter
- ENTPD4 p.Tyr225Cys Uncertain significance Single submitter
- ENTPD4 p.Tyr429Cys Uncertain significance Single submitter
- ENTPD4 p.Tyr435Cys Uncertain significance Single submitter
- ENTPD4 p.Tyr477His Uncertain significance Single submitter
- ENTPD4 p.Val164Ala Uncertain significance Single submitter
- ENTPD4 p.Val21Leu Uncertain significance Single submitter
- ENTPD4 p.Val317Leu Uncertain significance Single submitter
- ENTPD4 p.Val51Leu Uncertain significance Single submitter
- ENTPD4 p.Val573Leu Uncertain significance Single submitter
Predictors split 33
The independent predictors disagree with each other — read with care.
- ENTPD4 p.Ala214Thr Uncertain significance Single submitter
- ENTPD4 p.Ala462Glu Uncertain significance Single submitter
- ENTPD4 p.Arg263His Uncertain significance Single submitter
- ENTPD4 p.Arg396Gln Uncertain significance Single submitter
- ENTPD4 p.Arg469Trp Uncertain significance Single submitter
- ENTPD4 p.Arg584Gln Uncertain significance Single submitter
- ENTPD4 p.Asn414Ser Uncertain significance Single submitter
- ENTPD4 p.Asn86Ser Likely benign Single submitter
- ENTPD4 p.Asn88Ser Uncertain significance Single submitter
- ENTPD4 p.Asp151Gly Uncertain significance Single submitter
- ENTPD4 p.Asp206Asn Uncertain significance Single submitter
- ENTPD4 p.Asp375Gly Uncertain significance Single submitter
- ENTPD4 p.Glu147Gly Uncertain significance Single submitter
- ENTPD4 p.Ile384Met Likely benign Single submitter
- ENTPD4 p.Leu157Val Uncertain significance Single submitter
- ENTPD4 p.Leu177Val Uncertain significance Single submitter
- ENTPD4 p.Leu413Phe Uncertain significance Single submitter
- ENTPD4 p.Leu486Val Uncertain significance Single submitter
- ENTPD4 p.Leu517Phe Uncertain significance Single submitter
- ENTPD4 p.Lys134Arg Uncertain significance Single submitter
- ENTPD4 p.Lys464Asn Uncertain significance Single submitter
- ENTPD4 p.Met133Ile Uncertain significance Single submitter
- ENTPD4 p.Phe289Cys Uncertain significance Single submitter
- ENTPD4 p.Pro130Thr Uncertain significance Single submitter
- ENTPD4 p.Pro186Arg Uncertain significance Single submitter
- ENTPD4 p.Ser258Arg Uncertain significance Single submitter
- ENTPD4 p.Ser426Cys Uncertain significance Single submitter
- ENTPD4 p.Ser596Ile Uncertain significance Single submitter
- ENTPD4 p.Thr144Pro Uncertain significance Single submitter
- ENTPD4 p.Thr277Ile Uncertain significance Single submitter
- ENTPD4 p.Thr406Ala Uncertain significance Single submitter
- ENTPD4 p.Tyr417Cys Uncertain significance Single submitter
- ENTPD4 p.Tyr565Cys Uncertain significance Single submitter
All ENTPD4 variants
Likely benign 6
- p.Ala267= Single submitter
- p.Ala609Thr Single submitter
- p.Asn86Ser Single submitter ⚠
- p.Ile384Met Single submitter ⚠
- p.Ile399Leu Single submitter
- p.Val102Ile Single submitter
Uncertain significance 105
- p.Ala167Glu Single submitter ⚠
- p.Ala214Thr Single submitter ⚠
- p.Ala246Gly Single submitter ⚠
- p.Ala267Val Single submitter ⚠
- p.Ala280Val Single submitter ⚠
- p.Ala462Glu Single submitter ⚠
- p.Ala478Thr Single submitter ⚠
- p.Ala547Val Single submitter ⚠
- p.Ala599Thr Single submitter ⚠
- p.Arg109Ser Single submitter ⚠
- p.Arg166Gly Single submitter ⚠
- p.Arg263His Single submitter ⚠
- p.Arg396Gln Single submitter ⚠
- p.Arg469Gln Single submitter ⚠
- p.Arg469Trp Single submitter ⚠
- p.Arg471Leu Single submitter ⚠
- p.Arg474Gln Single submitter ⚠
- p.Arg485Gly Single submitter ⚠
- p.Arg536Cys Single submitter ⚠
- p.Arg549Gln Single submitter ⚠
- p.Arg584Gln Single submitter ⚠
- p.Arg587His Single submitter ⚠
- p.Arg594Gly Single submitter ⚠
- p.Asn111Asp Single submitter ⚠
- p.Asn113Ser Single submitter ⚠
- p.Asn251Ile Single submitter ⚠
- p.Asn349Ser Single submitter ⚠
- p.Asn414Ser Single submitter ⚠
- p.Asn509Ser Single submitter ⚠
- p.Asn86Asp Single submitter ⚠
- p.Asn88Ser Single submitter ⚠
- p.Asp125Gly Single submitter ⚠
- p.Asp151Gly Single submitter ⚠
- p.Asp206Asn Single submitter ⚠
- p.Asp310Gly Single submitter ⚠
- p.Asp375Gly Single submitter ⚠
- p.Cys570Trp Single submitter ⚠
- p.Gln544Glu Single submitter ⚠
- p.Glu141Ala Single submitter ⚠
- p.Glu147Gly Single submitter ⚠
- p.Glu238Asp Single submitter ⚠
- p.Glu238Gly Single submitter ⚠
- p.Glu259Lys Single submitter ⚠
- p.Glu282Asp Single submitter ⚠
- p.Glu439Lys Single submitter ⚠
- p.Gly22Glu Single submitter ⚠
- p.Gly235Glu Single submitter ⚠
- p.Gly329Asp Single submitter ⚠
- p.Gly329Ser Single submitter ⚠
- p.Gly430Ser Single submitter ⚠
- p.His480Arg Single submitter ⚠
- p.His480Leu Single submitter ⚠
- p.His552Leu Single submitter ⚠
- p.Ile217Met Single submitter ⚠
- p.Ile230Thr Single submitter ⚠
- p.Ile4Thr Single submitter ⚠
- p.Leu157Val Single submitter ⚠
- p.Leu177Val Single submitter ⚠
- p.Leu413Phe Single submitter ⚠
- p.Leu486Phe Single submitter ⚠
- p.Leu486Val Single submitter ⚠
- p.Leu517Phe Single submitter ⚠
- p.Leu71Arg Single submitter ⚠
- p.Lys134Arg Single submitter ⚠
- p.Lys168Glu Single submitter ⚠
- p.Lys464Asn Single submitter ⚠
- p.Met133Ile Single submitter ⚠
- p.Met444Ile Single submitter ⚠
- p.Met496Val Single submitter ⚠
- p.Phe237Leu Single submitter ⚠
- p.Phe289Cys Single submitter ⚠
- p.Phe434Leu Single submitter ⚠
- p.Phe560Ile Single submitter ⚠
- p.Pro130Thr Single submitter ⚠
- p.Pro137Arg Single submitter ⚠
- p.Pro137Ser Single submitter ⚠
- p.Pro186Arg Single submitter ⚠
- p.Pro20Ala Single submitter ⚠
- p.Pro20Ser Single submitter ⚠
- p.Pro363Gln Single submitter ⚠
- p.Pro539Leu Single submitter ⚠
- p.Pro593Thr Single submitter ⚠
- p.Pro608Thr Single submitter ⚠
- p.Pro613Leu Single submitter ⚠
- p.Ser17Cys Single submitter ⚠
- p.Ser258Arg Single submitter ⚠
- p.Ser276Leu Single submitter ⚠
- p.Ser426Cys Single submitter ⚠
- p.Ser596Ile Single submitter ⚠
- p.Thr144Pro Single submitter ⚠
- p.Thr277Ile Single submitter ⚠
- p.Thr406Ala Single submitter ⚠
- p.Thr62Ile Single submitter ⚠
- p.Tyr175Asn Single submitter ⚠
- p.Tyr225Cys Single submitter ⚠
- p.Tyr417Cys Single submitter ⚠
- p.Tyr429Cys Single submitter ⚠
- p.Tyr435Cys Single submitter ⚠
- p.Tyr477His Single submitter ⚠
- p.Tyr565Cys Single submitter ⚠
- p.Val164Ala Single submitter ⚠
- p.Val21Leu Single submitter ⚠
- p.Val317Leu Single submitter ⚠
- p.Val51Leu Single submitter ⚠
- p.Val573Leu Single submitter ⚠