ENTREP3 — 107 ClinVar variants
All ClinVar germline ENTREP3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 107 flagged for review →
107 Uncertain significance
Full ENTREP3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 107
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 64
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ENTREP3 p.Ala229Thr Uncertain significance Single submitter
- ENTREP3 p.Ala452Thr Uncertain significance Single submitter
- ENTREP3 p.Arg212Gln Uncertain significance Single submitter
- ENTREP3 p.Arg25His Uncertain significance Single submitter
- ENTREP3 p.Arg440Gly Uncertain significance Single submitter
- ENTREP3 p.Arg476Gln Uncertain significance Single submitter
- ENTREP3 p.Arg554Gln Uncertain significance Single submitter
- ENTREP3 p.Arg89Trp Uncertain significance Single submitter
- ENTREP3 p.Asp125Ala Uncertain significance Single submitter
- ENTREP3 p.Asp203Ala Uncertain significance Single submitter
- ENTREP3 p.Asp577Asn Uncertain significance Single submitter
- ENTREP3 p.Cys136Gly Uncertain significance Single submitter
- ENTREP3 p.Cys195Ser Uncertain significance Single submitter
- ENTREP3 p.Gln128His Uncertain significance Single submitter
- ENTREP3 p.Gln153Glu Uncertain significance Single submitter
- ENTREP3 p.Glu314Gln Uncertain significance Single submitter
- ENTREP3 p.Gly20Asp Uncertain significance Single submitter
- ENTREP3 p.Gly381Ser Uncertain significance Single submitter
- ENTREP3 p.Gly384Ser Uncertain significance Single submitter
- ENTREP3 p.Gly446Val Uncertain significance Single submitter
- ENTREP3 p.Gly447Glu Uncertain significance Single submitter
- ENTREP3 p.Gly45Arg Uncertain significance Single submitter
- ENTREP3 p.Gly45Ser Uncertain significance Single submitter
- ENTREP3 p.Gly605Arg Uncertain significance Single submitter
- ENTREP3 p.Gly608Val Uncertain significance Single submitter
- ENTREP3 p.Gly645Ser Uncertain significance Single submitter
- ENTREP3 p.Gly661Arg Uncertain significance Single submitter
- ENTREP3 p.Gly80Arg Uncertain significance Single submitter
- ENTREP3 p.His233Tyr Uncertain significance Single submitter
- ENTREP3 p.His23Gln Uncertain significance Single submitter
- ENTREP3 p.His626Tyr Uncertain significance Single submitter
- ENTREP3 p.His655Arg Uncertain significance Single submitter
- ENTREP3 p.Leu145Val Uncertain significance Single submitter
- ENTREP3 p.Leu218Arg Uncertain significance Single submitter
- ENTREP3 p.Leu26Phe Uncertain significance Single submitter
- ENTREP3 p.Leu31Val Uncertain significance Single submitter
- ENTREP3 p.Leu391Pro Uncertain significance Single submitter
- ENTREP3 p.Lys562Glu Uncertain significance Single submitter
- ENTREP3 p.Phe98Ser Uncertain significance Single submitter
- ENTREP3 p.Pro230Leu Uncertain significance Single submitter
- ENTREP3 p.Pro248Leu Uncertain significance Single submitter
- ENTREP3 p.Pro412Ala Uncertain significance Single submitter
- ENTREP3 p.Pro434Leu Uncertain significance Single submitter
- ENTREP3 p.Pro472Leu Uncertain significance Single submitter
- ENTREP3 p.Pro477Ser Uncertain significance Single submitter
- ENTREP3 p.Pro571Ser Uncertain significance Single submitter
- ENTREP3 p.Pro69Leu Uncertain significance Single submitter
- ENTREP3 p.Ser113Pro Uncertain significance Single submitter
- ENTREP3 p.Ser151Leu Uncertain significance Single submitter
- ENTREP3 p.Ser310Leu Uncertain significance Single submitter
- ENTREP3 p.Ser318Thr Uncertain significance Single submitter
- ENTREP3 p.Ser6Thr Uncertain significance Single submitter
- ENTREP3 p.Thr207Met Uncertain significance Single submitter
- ENTREP3 p.Trp431Cys Uncertain significance Single submitter
- ENTREP3 p.Tyr251Phe Uncertain significance Single submitter
- ENTREP3 p.Tyr255His Uncertain significance Single submitter
- ENTREP3 p.Val194Leu Uncertain significance Single submitter
- ENTREP3 p.Val205Leu Uncertain significance Single submitter
- ENTREP3 p.Val205Met Uncertain significance Single submitter
- ENTREP3 p.Val322Ala Uncertain significance Single submitter
- ENTREP3 p.Val362Ile Uncertain significance Single submitter
- ENTREP3 p.Val443Phe Uncertain significance Single submitter
- ENTREP3 p.Val49Ile Uncertain significance Single submitter
- ENTREP3 p.Val58Ile Uncertain significance Single submitter
Predictors split 43
The independent predictors disagree with each other — read with care.
- ENTREP3 p.Arg212Trp Uncertain significance Single submitter
- ENTREP3 p.Arg371Pro Uncertain significance Single submitter
- ENTREP3 p.Arg393Gln Uncertain significance Single submitter
- ENTREP3 p.Arg400Cys Uncertain significance Single submitter
- ENTREP3 p.Arg461Cys Uncertain significance Single submitter
- ENTREP3 p.Arg539Cys Uncertain significance Single submitter
- ENTREP3 p.Arg547Cys Uncertain significance Single submitter
- ENTREP3 p.Arg547Leu Uncertain significance Single submitter
- ENTREP3 p.Arg554Trp Uncertain significance Single submitter
- ENTREP3 p.Arg555His Uncertain significance Single submitter
- ENTREP3 p.Arg590His Uncertain significance Single submitter
- ENTREP3 p.Arg641Ser Uncertain significance Single submitter
- ENTREP3 p.Arg646Cys Uncertain significance Single submitter
- ENTREP3 p.Arg650His Uncertain significance Single submitter
- ENTREP3 p.Arg653Cys Uncertain significance Single submitter
- ENTREP3 p.Arg653His Uncertain significance Single submitter
- ENTREP3 p.Cys380Tyr Uncertain significance Single submitter
- ENTREP3 p.Cys404Gly Uncertain significance Single submitter
- ENTREP3 p.Cys630Phe Uncertain significance Single submitter
- ENTREP3 p.Glu260Lys Uncertain significance Single submitter
- ENTREP3 p.Glu345Gly Uncertain significance Single submitter
- ENTREP3 p.Glu387Lys Uncertain significance Single submitter
- ENTREP3 p.Gly527Val Uncertain significance Single submitter
- ENTREP3 p.Gly631Arg Uncertain significance Single submitter
- ENTREP3 p.His573Tyr Uncertain significance Single submitter
- ENTREP3 p.Leu337Phe Uncertain significance Single submitter
- ENTREP3 p.Leu391Met Uncertain significance Single submitter
- ENTREP3 p.Pro228Leu Uncertain significance Single submitter
- ENTREP3 p.Pro455Leu Uncertain significance Single submitter
- ENTREP3 p.Pro541Thr Uncertain significance Single submitter
- ENTREP3 p.Ser318Tyr Uncertain significance Single submitter
- ENTREP3 p.Ser328Ala Uncertain significance Single submitter
- ENTREP3 p.Ser389Ile Uncertain significance Single submitter
- ENTREP3 p.Ser464Gly Uncertain significance Single submitter
- ENTREP3 p.Ser464Ile Uncertain significance Single submitter
- ENTREP3 p.Ser656Gly Uncertain significance Single submitter
- ENTREP3 p.Ser96Phe Uncertain significance Single submitter
- ENTREP3 p.Thr224Lys Uncertain significance Single submitter
- ENTREP3 p.Thr224Met Uncertain significance Single submitter
- ENTREP3 p.Thr267Ala Uncertain significance Single submitter
- ENTREP3 p.Thr36Met Uncertain significance Single submitter
- ENTREP3 p.Thr498Met Uncertain significance Single submitter
- ENTREP3 p.Val177Ile Uncertain significance Single submitter
All ENTREP3 variants
Uncertain significance 107
- p.Ala229Thr Single submitter ⚠
- p.Ala452Thr Single submitter ⚠
- p.Arg212Gln Single submitter ⚠
- p.Arg212Trp Single submitter ⚠
- p.Arg25His Single submitter ⚠
- p.Arg371Pro Single submitter ⚠
- p.Arg393Gln Single submitter ⚠
- p.Arg400Cys Single submitter ⚠
- p.Arg440Gly Single submitter ⚠
- p.Arg461Cys Single submitter ⚠
- p.Arg476Gln Single submitter ⚠
- p.Arg539Cys Single submitter ⚠
- p.Arg547Cys Single submitter ⚠
- p.Arg547Leu Single submitter ⚠
- p.Arg554Gln Single submitter ⚠
- p.Arg554Trp Single submitter ⚠
- p.Arg555His Single submitter ⚠
- p.Arg590His Single submitter ⚠
- p.Arg641Ser Single submitter ⚠
- p.Arg646Cys Single submitter ⚠
- p.Arg650His Single submitter ⚠
- p.Arg653Cys Single submitter ⚠
- p.Arg653His Single submitter ⚠
- p.Arg89Trp Single submitter ⚠
- p.Asp125Ala Single submitter ⚠
- p.Asp203Ala Single submitter ⚠
- p.Asp577Asn Single submitter ⚠
- p.Cys136Gly Single submitter ⚠
- p.Cys195Ser Single submitter ⚠
- p.Cys380Tyr Single submitter ⚠
- p.Cys404Gly Single submitter ⚠
- p.Cys630Phe Single submitter ⚠
- p.Gln128His Single submitter ⚠
- p.Gln153Glu Single submitter ⚠
- p.Glu260Lys Single submitter ⚠
- p.Glu314Gln Single submitter ⚠
- p.Glu345Gly Single submitter ⚠
- p.Glu387Lys Single submitter ⚠
- p.Gly20Asp Single submitter ⚠
- p.Gly381Ser Single submitter ⚠
- p.Gly384Ser Single submitter ⚠
- p.Gly446Val Single submitter ⚠
- p.Gly447Glu Single submitter ⚠
- p.Gly45Arg Single submitter ⚠
- p.Gly45Ser Single submitter ⚠
- p.Gly527Val Single submitter ⚠
- p.Gly605Arg Single submitter ⚠
- p.Gly608Val Single submitter ⚠
- p.Gly631Arg Single submitter ⚠
- p.Gly645Ser Single submitter ⚠
- p.Gly661Arg Single submitter ⚠
- p.Gly80Arg Single submitter ⚠
- p.His233Tyr Single submitter ⚠
- p.His23Gln Single submitter ⚠
- p.His573Tyr Single submitter ⚠
- p.His626Tyr Single submitter ⚠
- p.His655Arg Single submitter ⚠
- p.Leu145Val Single submitter ⚠
- p.Leu218Arg Single submitter ⚠
- p.Leu26Phe Single submitter ⚠
- p.Leu31Val Single submitter ⚠
- p.Leu337Phe Single submitter ⚠
- p.Leu391Met Single submitter ⚠
- p.Leu391Pro Single submitter ⚠
- p.Lys562Glu Single submitter ⚠
- p.Phe98Ser Single submitter ⚠
- p.Pro228Leu Single submitter ⚠
- p.Pro230Leu Single submitter ⚠
- p.Pro248Leu Single submitter ⚠
- p.Pro412Ala Single submitter ⚠
- p.Pro434Leu Single submitter ⚠
- p.Pro455Leu Single submitter ⚠
- p.Pro472Leu Single submitter ⚠
- p.Pro477Ser Single submitter ⚠
- p.Pro541Thr Single submitter ⚠
- p.Pro571Ser Single submitter ⚠
- p.Pro69Leu Single submitter ⚠
- p.Ser113Pro Single submitter ⚠
- p.Ser151Leu Single submitter ⚠
- p.Ser310Leu Single submitter ⚠
- p.Ser318Thr Single submitter ⚠
- p.Ser318Tyr Single submitter ⚠
- p.Ser328Ala Single submitter ⚠
- p.Ser389Ile Single submitter ⚠
- p.Ser464Gly Single submitter ⚠
- p.Ser464Ile Single submitter ⚠
- p.Ser656Gly Single submitter ⚠
- p.Ser6Thr Single submitter ⚠
- p.Ser96Phe Single submitter ⚠
- p.Thr207Met Single submitter ⚠
- p.Thr224Lys Single submitter ⚠
- p.Thr224Met Single submitter ⚠
- p.Thr267Ala Single submitter ⚠
- p.Thr36Met Single submitter ⚠
- p.Thr498Met Single submitter ⚠
- p.Trp431Cys Single submitter ⚠
- p.Tyr251Phe Single submitter ⚠
- p.Tyr255His Single submitter ⚠
- p.Val177Ile Single submitter ⚠
- p.Val194Leu Single submitter ⚠
- p.Val205Leu Single submitter ⚠
- p.Val205Met Single submitter ⚠
- p.Val322Ala Single submitter ⚠
- p.Val362Ile Single submitter ⚠
- p.Val443Phe Single submitter ⚠
- p.Val49Ile Single submitter ⚠
- p.Val58Ile Single submitter ⚠