EPHX3 — 73 ClinVar variants
All ClinVar germline EPHX3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 62 flagged for review →
1 Benign · 5 Likely benign · 67 Uncertain significance
Full EPHX3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 62
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 48
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- EPHX3 p.Ala176Asp Uncertain significance Single submitter
- EPHX3 p.Ala176Thr Uncertain significance Single submitter
- EPHX3 p.Ala22Ser Uncertain significance Single submitter
- EPHX3 p.Ala65Ser Uncertain significance Single submitter
- EPHX3 p.Ala65Thr Uncertain significance Single submitter
- EPHX3 p.Arg114His Uncertain significance Single submitter
- EPHX3 p.Arg118Gln Uncertain significance Single submitter
- EPHX3 p.Arg118Leu Uncertain significance Single submitter
- EPHX3 p.Arg217Cys Uncertain significance Single submitter
- EPHX3 p.Arg217His Uncertain significance Single submitter
- EPHX3 p.Arg249Cys Uncertain significance Single submitter
- EPHX3 p.Arg321Cys Uncertain significance Single submitter
- EPHX3 p.Arg50Trp Uncertain significance Single submitter
- EPHX3 p.Arg60Trp Uncertain significance Single submitter
- EPHX3 p.Asn343Lys Uncertain significance Single submitter
- EPHX3 p.Asn96Lys Uncertain significance Single submitter
- EPHX3 p.Asp149Asn Uncertain significance Single submitter
- EPHX3 p.Cys49Trp Uncertain significance Single submitter
- EPHX3 p.Glu311Asp Uncertain significance Single submitter
- EPHX3 p.Glu74Gly Uncertain significance Single submitter
- EPHX3 p.Gly105Arg Uncertain significance Single submitter
- EPHX3 p.Gly105Val Uncertain significance Single submitter
- EPHX3 p.Gly198Ser Uncertain significance Single submitter
- EPHX3 p.His210Tyr Uncertain significance Single submitter
- EPHX3 p.His348Gln Uncertain significance Single submitter
- EPHX3 p.His75Asn Uncertain significance Single submitter
- EPHX3 p.Ile148Leu Uncertain significance Single submitter
- EPHX3 p.Ile155Val Uncertain significance Single submitter
- EPHX3 p.Ile335Thr Uncertain significance Single submitter
- EPHX3 p.Leu131Phe Uncertain significance Single submitter
- EPHX3 p.Leu284Phe Uncertain significance Single submitter
- EPHX3 p.Leu44His Uncertain significance Single submitter
- EPHX3 p.Lys18Thr Uncertain significance Single submitter
- EPHX3 p.Lys232Gln Uncertain significance Single submitter
- EPHX3 p.Met100Val Uncertain significance Single submitter
- EPHX3 p.Met24Leu Uncertain significance Single submitter
- EPHX3 p.Phe29Cys Uncertain significance Single submitter
- EPHX3 p.Pro136Thr Uncertain significance Single submitter
- EPHX3 p.Pro289Thr Uncertain significance Single submitter
- EPHX3 p.Ser137Trp Uncertain significance Single submitter
- EPHX3 p.Ser188Phe Uncertain significance Single submitter
- EPHX3 p.Ser202Leu Uncertain significance Single submitter
- EPHX3 p.Ser71Leu Uncertain significance Single submitter
- EPHX3 p.Ser91Leu Uncertain significance Single submitter
- EPHX3 p.Thr251Lys Uncertain significance Single submitter
- EPHX3 p.Val323Leu Uncertain significance Single submitter
- EPHX3 p.Val47Ala Uncertain significance Single submitter
- EPHX3 p.Val47Met Uncertain significance Single submitter
Predictors split 14
The independent predictors disagree with each other — read with care.
- EPHX3 p.Arg114Cys Uncertain significance Single submitter
- EPHX3 p.Arg192Gln Uncertain significance Single submitter
- EPHX3 p.Arg86His Uncertain significance Single submitter
- EPHX3 p.Glu231Lys Uncertain significance Single submitter
- EPHX3 p.Glu260Lys Uncertain significance Single submitter
- EPHX3 p.Gly325Cys Uncertain significance Single submitter
- EPHX3 p.His248Tyr Uncertain significance Single submitter
- EPHX3 p.His88Gln Uncertain significance Single submitter
- EPHX3 p.Phe111Leu Uncertain significance Single submitter
- EPHX3 p.Phe264Leu Uncertain significance Single submitter
- EPHX3 p.Pro298Leu Uncertain significance Single submitter
- EPHX3 p.Ser269Leu Uncertain significance Single submitter
- EPHX3 p.Ser26Arg Uncertain significance Single submitter
- EPHX3 p.Trp303Leu Uncertain significance Single submitter
All EPHX3 variants
Benign 1
- p.Pro98= Single submitter
Likely benign 5
- p.Arg249His Single submitter
- p.Gly336= Single submitter
- p.Ile168Val Single submitter
- p.Leu310Phe Single submitter
- p.Pro230= Single submitter
Uncertain significance 67
- p.Ala176Asp Single submitter ⚠
- p.Ala176Thr Single submitter ⚠
- p.Ala22Ser Single submitter ⚠
- p.Ala65Ser Single submitter ⚠
- p.Ala65Thr Single submitter ⚠
- p.Arg114Cys Single submitter ⚠
- p.Arg114His Single submitter ⚠
- p.Arg118Gln Single submitter ⚠
- p.Arg118Leu Single submitter ⚠
- p.Arg14Leu Single submitter
- p.Arg192Gln Single submitter ⚠
- p.Arg217Cys Single submitter ⚠
- p.Arg217His Single submitter ⚠
- p.Arg249Cys Single submitter ⚠
- p.Arg321Cys Single submitter ⚠
- p.Arg50Trp Single submitter ⚠
- p.Arg60Trp Single submitter ⚠
- p.Arg86His Single submitter ⚠
- p.Asn343Lys Single submitter ⚠
- p.Asn96Lys Single submitter ⚠
- p.Asp149Asn Single submitter ⚠
- p.Cys49Trp Single submitter ⚠
- p.Glu231Lys Single submitter ⚠
- p.Glu260Lys Single submitter ⚠
- p.Glu311Asp Single submitter ⚠
- p.Glu74Gly Single submitter ⚠
- p.Gly105Arg Single submitter ⚠
- p.Gly105Val Single submitter ⚠
- p.Gly198Ser Single submitter ⚠
- p.Gly325Cys Single submitter ⚠
- p.His210Tyr Single submitter ⚠
- p.His248Tyr Single submitter ⚠
- p.His348Gln Single submitter ⚠
- p.His75Asn Single submitter ⚠
- p.His88Gln Single submitter ⚠
- p.Ile148Leu Single submitter ⚠
- p.Ile155Val Single submitter ⚠
- p.Ile335Thr Single submitter ⚠
- p.Leu131Phe Single submitter ⚠
- p.Leu162Arg Single submitter
- p.Leu169Phe Single submitter
- p.Leu284Phe Single submitter ⚠
- p.Leu33Pro Single submitter
- p.Leu44His Single submitter ⚠
- p.Leu48Pro Single submitter
- p.Lys18Thr Single submitter ⚠
- p.Lys232Gln Single submitter ⚠
- p.Met100Val Single submitter ⚠
- p.Met24Leu Single submitter ⚠
- p.Phe111Leu Single submitter ⚠
- p.Phe264Leu Single submitter ⚠
- p.Phe29Cys Single submitter ⚠
- p.Pro136Thr Single submitter ⚠
- p.Pro289Thr Single submitter ⚠
- p.Pro298Leu Single submitter ⚠
- p.Ser137Trp Single submitter ⚠
- p.Ser188Phe Single submitter ⚠
- p.Ser202Leu Single submitter ⚠
- p.Ser269Leu Single submitter ⚠
- p.Ser26Arg Single submitter ⚠
- p.Ser71Leu Single submitter ⚠
- p.Ser91Leu Single submitter ⚠
- p.Thr251Lys Single submitter ⚠
- p.Trp303Leu Single submitter ⚠
- p.Val323Leu Single submitter ⚠
- p.Val47Ala Single submitter ⚠
- p.Val47Met Single submitter ⚠