EPHX4 — 49 ClinVar variants
All ClinVar germline EPHX4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 47 flagged for review →
49 Uncertain significance
Full EPHX4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 47
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 37
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- EPHX4 p.Ala135Val Uncertain significance Single submitter
- EPHX4 p.Ala209Thr Uncertain significance Single submitter
- EPHX4 p.Ala308Thr Uncertain significance Single submitter
- EPHX4 p.Ala32Val Uncertain significance Single submitter
- EPHX4 p.Arg10His Uncertain significance Single submitter
- EPHX4 p.Asn233Ser Uncertain significance Single submitter
- EPHX4 p.Asp6Tyr Uncertain significance Single submitter
- EPHX4 p.Gln49Arg Uncertain significance Single submitter
- EPHX4 p.Glu119Ala Uncertain significance Single submitter
- EPHX4 p.Glu184Lys Uncertain significance Single submitter
- EPHX4 p.Glu57Lys Uncertain significance Single submitter
- EPHX4 p.Gly167Cys Uncertain significance Single submitter
- EPHX4 p.Gly253Arg Uncertain significance Single submitter
- EPHX4 p.Gly69Cys Uncertain significance Single submitter
- EPHX4 p.His240Tyr Uncertain significance Single submitter
- EPHX4 p.Ile148Thr Uncertain significance Single submitter
- EPHX4 p.Ile180Val Uncertain significance Single submitter
- EPHX4 p.Ile190Val Uncertain significance Single submitter
- EPHX4 p.Leu125Val Uncertain significance Single submitter
- EPHX4 p.Leu147Pro Uncertain significance Single submitter
- EPHX4 p.Leu30Phe Uncertain significance Single submitter
- EPHX4 p.Leu331Ser Uncertain significance Single submitter
- EPHX4 p.Leu63Val Uncertain significance Single submitter
- EPHX4 p.Lys143Thr Uncertain significance Single submitter
- EPHX4 p.Lys152Arg Uncertain significance Single submitter
- EPHX4 p.Lys355Glu Uncertain significance Single submitter
- EPHX4 p.Lys360Asn Uncertain significance Single submitter
- EPHX4 p.Ser118Arg Uncertain significance Single submitter
- EPHX4 p.Ser335Thr Uncertain significance Single submitter
- EPHX4 p.Ser67Thr Uncertain significance Single submitter
- EPHX4 p.Thr14Met Uncertain significance Single submitter
- EPHX4 p.Thr201Ile Uncertain significance Single submitter
- EPHX4 p.Thr358Ile Uncertain significance Single submitter
- EPHX4 p.Trp170Ser Uncertain significance Single submitter
- EPHX4 p.Tyr325Ser Uncertain significance Single submitter
- EPHX4 p.Val267Ile Uncertain significance Single submitter
- EPHX4 p.Val312Gly Uncertain significance Single submitter
Predictors split 10
The independent predictors disagree with each other — read with care.
- EPHX4 p.Ala32Pro Uncertain significance Single submitter
- EPHX4 p.Arg114Gly Uncertain significance Single submitter
- EPHX4 p.Asn279Ser Uncertain significance Single submitter
- EPHX4 p.Gly131Arg Uncertain significance Single submitter
- EPHX4 p.Gly276Ser Uncertain significance Single submitter
- EPHX4 p.Phe219Leu Uncertain significance Single submitter
- EPHX4 p.Pro271Leu Uncertain significance Single submitter
- EPHX4 p.Pro94Leu Uncertain significance Single submitter
- EPHX4 p.Thr318Ile Uncertain significance Single submitter
- EPHX4 p.Tyr216Cys Uncertain significance Single submitter
All EPHX4 variants
Uncertain significance 49
- p.Ala135Val Single submitter ⚠
- p.Ala209Thr Single submitter ⚠
- p.Ala308Thr Single submitter ⚠
- p.Ala32Pro Single submitter ⚠
- p.Ala32Val Single submitter ⚠
- p.Arg10His Single submitter ⚠
- p.Arg114Gly Single submitter ⚠
- p.Arg121Gln Single submitter
- p.Asn233Ser Single submitter ⚠
- p.Asn279Ser Single submitter ⚠
- p.Asp260Asn Single submitter
- p.Asp6Tyr Single submitter ⚠
- p.Gln49Arg Single submitter ⚠
- p.Glu119Ala Single submitter ⚠
- p.Glu184Lys Single submitter ⚠
- p.Glu57Lys Single submitter ⚠
- p.Gly131Arg Single submitter ⚠
- p.Gly167Cys Single submitter ⚠
- p.Gly253Arg Single submitter ⚠
- p.Gly276Ser Single submitter ⚠
- p.Gly69Cys Single submitter ⚠
- p.His240Tyr Single submitter ⚠
- p.Ile148Thr Single submitter ⚠
- p.Ile180Val Single submitter ⚠
- p.Ile190Val Single submitter ⚠
- p.Leu125Val Single submitter ⚠
- p.Leu147Pro Single submitter ⚠
- p.Leu30Phe Single submitter ⚠
- p.Leu331Ser Single submitter ⚠
- p.Leu63Val Single submitter ⚠
- p.Lys143Thr Single submitter ⚠
- p.Lys152Arg Single submitter ⚠
- p.Lys355Glu Single submitter ⚠
- p.Lys360Asn Single submitter ⚠
- p.Phe219Leu Single submitter ⚠
- p.Pro271Leu Single submitter ⚠
- p.Pro94Leu Single submitter ⚠
- p.Ser118Arg Single submitter ⚠
- p.Ser335Thr Single submitter ⚠
- p.Ser67Thr Single submitter ⚠
- p.Thr14Met Single submitter ⚠
- p.Thr201Ile Single submitter ⚠
- p.Thr318Ile Single submitter ⚠
- p.Thr358Ile Single submitter ⚠
- p.Trp170Ser Single submitter ⚠
- p.Tyr216Cys Single submitter ⚠
- p.Tyr325Ser Single submitter ⚠
- p.Val267Ile Single submitter ⚠
- p.Val312Gly Single submitter ⚠