ERAS — 18 ClinVar variants
All ClinVar germline ERAS variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 13 flagged for review →
1 Benign · 3 Likely benign · 14 Uncertain significance
Full ERAS gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 13
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 11
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ERAS p.Ala15Val Uncertain significance Single submitter
- ERAS p.Ala165Thr Uncertain significance Single submitter
- ERAS p.Arg220Trp Uncertain significance Single submitter
- ERAS p.Arg32His Uncertain significance Single submitter
- ERAS p.Cys215Tyr Uncertain significance Single submitter
- ERAS p.Gln186Arg Uncertain significance Single submitter
- ERAS p.Gly23Arg Uncertain significance Single submitter
- ERAS p.Ser126Leu Uncertain significance Single submitter
- ERAS p.Thr83Ser Uncertain significance Single submitter
- ERAS p.Val116Ala Uncertain significance Single submitter
- ERAS p.Val116Leu Uncertain significance Single submitter
Predictors split 2
The independent predictors disagree with each other — read with care.
All ERAS variants
Benign 1
- p.Gly118= Multiple submitters
Likely benign 3
- p.Ala164= Single submitter
- p.Phe120= Single submitter
- p.Pro210Ala Single submitter
Uncertain significance 14
- p.Ala121Thr Single submitter
- p.Ala15Val Single submitter ⚠
- p.Ala165Thr Single submitter ⚠
- p.Ala175Thr Single submitter ⚠
- p.Arg220Trp Single submitter ⚠
- p.Arg32His Single submitter ⚠
- p.Cys215Tyr Single submitter ⚠
- p.Gln186Arg Single submitter ⚠
- p.Gly23Arg Single submitter ⚠
- p.His102Pro Single submitter ⚠
- p.Ser126Leu Single submitter ⚠
- p.Thr83Ser Single submitter ⚠
- p.Val116Ala Single submitter ⚠
- p.Val116Leu Single submitter ⚠