Sugi Variant

Sugi Variant/ERBB2

ERBB2 — 772 ClinVar variants

All ClinVar germline ERBB2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 353 flagged for review →

15 Pathogenic · 1 Pathogenic/Likely pathogenic · 4 Likely pathogenic · 9 Conflicting · 36 Benign · 5 Benign/Likely benign · 318 Likely benign · 384 Uncertain significance

Full ERBB2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 353

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors vs ClinVar 4

ClinVar calls these pathogenic, but the computational predictors lean tolerated — the highest-value review flag.

Predictors agree, ClinVar conflicts 1

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 198

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification. · showing the 150 best-reviewed of 198

Predictors split 150

The independent predictors disagree with each other — read with care.

All ERBB2 variants

Pathogenic 15

Pathogenic/Likely pathogenic 1

  • p.Leu755Pro No assertion criteria lung adenocarcinoma

Likely pathogenic 4

Conflicting classifications of pathogenicity 9

Benign 36

Benign/Likely benign 5

Likely benign 318

Showing the top 300 by review status; the full set is in the sitemap.

Uncertain significance 384

Showing the top 300 by review status; the full set is in the sitemap.