ERICH6 — 107 ClinVar variants
All ClinVar germline ERICH6 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 100 flagged for review →
8 Likely benign · 99 Uncertain significance
Full ERICH6 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 100
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 66
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ERICH6 p.Ala320Gly Uncertain significance Single submitter
- ERICH6 p.Ala479Ser Uncertain significance Single submitter
- ERICH6 p.Arg414Trp Uncertain significance Single submitter
- ERICH6 p.Asn403Lys Uncertain significance Single submitter
- ERICH6 p.Asn504Ser Uncertain significance Single submitter
- ERICH6 p.Asn516Ser Uncertain significance Single submitter
- ERICH6 p.Asn522Ser Uncertain significance Single submitter
- ERICH6 p.Asp153Asn Uncertain significance Single submitter
- ERICH6 p.Asp153Glu Uncertain significance Single submitter
- ERICH6 p.Asp277Asn Uncertain significance Single submitter
- ERICH6 p.Asp326His Uncertain significance Single submitter
- ERICH6 p.Asp88Glu Uncertain significance Single submitter
- ERICH6 p.Cys197Tyr Uncertain significance Single submitter
- ERICH6 p.Cys271Tyr Uncertain significance Single submitter
- ERICH6 p.Cys274Phe Uncertain significance Single submitter
- ERICH6 p.Cys492Gly Uncertain significance Single submitter
- ERICH6 p.Cys613Phe Uncertain significance Single submitter
- ERICH6 p.Gln114Arg Uncertain significance Single submitter
- ERICH6 p.Gln18Leu Uncertain significance Single submitter
- ERICH6 p.Gln513Glu Uncertain significance Single submitter
- ERICH6 p.Glu212Val Uncertain significance Single submitter
- ERICH6 p.Glu251Gly Uncertain significance Single submitter
- ERICH6 p.Glu369Val Uncertain significance Single submitter
- ERICH6 p.Glu581Lys Uncertain significance Single submitter
- ERICH6 p.Gly508Asp Uncertain significance Single submitter
- ERICH6 p.Gly572Glu Uncertain significance Single submitter
- ERICH6 p.Gly646Asp Uncertain significance Single submitter
- ERICH6 p.His133Arg Uncertain significance Single submitter
- ERICH6 p.His356Tyr Uncertain significance Single submitter
- ERICH6 p.His494Arg Uncertain significance Single submitter
- ERICH6 p.Ile208Phe Uncertain significance Single submitter
- ERICH6 p.Ile359Thr Uncertain significance Single submitter
- ERICH6 p.Ile558Val Uncertain significance Single submitter
- ERICH6 p.Ile583Thr Uncertain significance Single submitter
- ERICH6 p.Ile647Met Uncertain significance Single submitter
- ERICH6 p.Leu600Phe Uncertain significance Single submitter
- ERICH6 p.Lys419Thr Uncertain significance Single submitter
- ERICH6 p.Lys80Glu Uncertain significance Single submitter
- ERICH6 p.Met150Lys Uncertain significance Single submitter
- ERICH6 p.Phe110Ile Uncertain significance Single submitter
- ERICH6 p.Phe110Leu Uncertain significance Single submitter
- ERICH6 p.Phe367Leu Uncertain significance Single submitter
- ERICH6 p.Phe367Tyr Uncertain significance Single submitter
- ERICH6 p.Phe399Ser Uncertain significance Single submitter
- ERICH6 p.Pro122Ala Uncertain significance Single submitter
- ERICH6 p.Pro13Thr Uncertain significance Single submitter
- ERICH6 p.Pro628Ser Uncertain significance Single submitter
- ERICH6 p.Pro7Ser Uncertain significance Single submitter
- ERICH6 p.Pro92Ser Uncertain significance Single submitter
- ERICH6 p.Pro96Ser Uncertain significance Single submitter
- ERICH6 p.Ser103Thr Uncertain significance Single submitter
- ERICH6 p.Ser123Thr Uncertain significance Single submitter
- ERICH6 p.Ser167Leu Uncertain significance Single submitter
- ERICH6 p.Ser368Phe Uncertain significance Single submitter
- ERICH6 p.Ser599Ile Uncertain significance Single submitter
- ERICH6 p.Ser8Arg Uncertain significance Single submitter
- ERICH6 p.Tyr510Cys Uncertain significance Single submitter
- ERICH6 p.Tyr588Phe Uncertain significance Single submitter
- ERICH6 p.Tyr77Asp Uncertain significance Single submitter
- ERICH6 p.Val182Gly Uncertain significance Single submitter
- ERICH6 p.Val182Leu Uncertain significance Single submitter
- ERICH6 p.Val335Ala Uncertain significance Single submitter
- ERICH6 p.Val396Ala Uncertain significance Single submitter
- ERICH6 p.Val463Ala Uncertain significance Single submitter
- ERICH6 p.Val589Ile Uncertain significance Single submitter
- ERICH6 p.Val81Phe Uncertain significance Single submitter
Predictors split 34
The independent predictors disagree with each other — read with care.
- ERICH6 p.Ala354Val Uncertain significance Single submitter
- ERICH6 p.Ala562Ser Uncertain significance Single submitter
- ERICH6 p.Arg374Cys Uncertain significance Single submitter
- ERICH6 p.Arg414Pro Uncertain significance Single submitter
- ERICH6 p.Arg458Gln Uncertain significance Single submitter
- ERICH6 p.Arg544Gly Uncertain significance Single submitter
- ERICH6 p.Arg549His Uncertain significance Single submitter
- ERICH6 p.Arg605Cys Uncertain significance Single submitter
- ERICH6 p.Asn461Lys Uncertain significance Single submitter
- ERICH6 p.Asp336Asn Uncertain significance Single submitter
- ERICH6 p.Asp336Gly Uncertain significance Single submitter
- ERICH6 p.Asp394Gly Uncertain significance Single submitter
- ERICH6 p.Asp394Val Uncertain significance Single submitter
- ERICH6 p.Glu28Val Uncertain significance Single submitter
- ERICH6 p.Glu54Val Uncertain significance Single submitter
- ERICH6 p.Glu59Val Uncertain significance Single submitter
- ERICH6 p.Gly293Trp Uncertain significance Single submitter
- ERICH6 p.Gly547Ala Uncertain significance Single submitter
- ERICH6 p.His328Tyr Uncertain significance Single submitter
- ERICH6 p.Ile325Thr Uncertain significance Single submitter
- ERICH6 p.Ile503Val Uncertain significance Single submitter
- ERICH6 p.Ile550Leu Uncertain significance Single submitter
- ERICH6 p.Ile659Met Uncertain significance Single submitter
- ERICH6 p.Ile659Thr Uncertain significance Single submitter
- ERICH6 p.Leu238Ser Uncertain significance Single submitter
- ERICH6 p.Met563Val Uncertain significance Single submitter
- ERICH6 p.Ser490Thr Uncertain significance Single submitter
- ERICH6 p.Ser635Phe Uncertain significance Single submitter
- ERICH6 p.Thr467Ile Uncertain significance Single submitter
- ERICH6 p.Tyr493Cys Uncertain significance Single submitter
- ERICH6 p.Tyr630Cys Uncertain significance Single submitter
- ERICH6 p.Val34Met Likely benign Single submitter
- ERICH6 p.Val548Ala Uncertain significance Single submitter
- ERICH6 p.Val575Gly Uncertain significance Single submitter
All ERICH6 variants
Likely benign 8
- p.Glu196Gln Single submitter
- p.Glu32= Single submitter
- p.Glu46= Single submitter
- p.Gly9Ser Single submitter
- p.His157Tyr Single submitter
- p.Pro317Ser Single submitter
- p.Val34Met Single submitter ⚠
- p.Val589Leu Single submitter
Uncertain significance 99
- p.Ala320Gly Single submitter ⚠
- p.Ala354Val Single submitter ⚠
- p.Ala479Ser Single submitter ⚠
- p.Ala562Ser Single submitter ⚠
- p.Arg374Cys Single submitter ⚠
- p.Arg414Pro Single submitter ⚠
- p.Arg414Trp Single submitter ⚠
- p.Arg458Gln Single submitter ⚠
- p.Arg544Gly Single submitter ⚠
- p.Arg549His Single submitter ⚠
- p.Arg605Cys Single submitter ⚠
- p.Asn403Lys Single submitter ⚠
- p.Asn461Lys Single submitter ⚠
- p.Asn504Ser Single submitter ⚠
- p.Asn516Ser Single submitter ⚠
- p.Asn522Ser Single submitter ⚠
- p.Asp153Asn Single submitter ⚠
- p.Asp153Glu Single submitter ⚠
- p.Asp277Asn Single submitter ⚠
- p.Asp326His Single submitter ⚠
- p.Asp336Asn Single submitter ⚠
- p.Asp336Gly Single submitter ⚠
- p.Asp394Gly Single submitter ⚠
- p.Asp394Val Single submitter ⚠
- p.Asp88Glu Single submitter ⚠
- p.Cys197Tyr Single submitter ⚠
- p.Cys271Tyr Single submitter ⚠
- p.Cys274Phe Single submitter ⚠
- p.Cys492Gly Single submitter ⚠
- p.Cys613Phe Single submitter ⚠
- p.Gln114Arg Single submitter ⚠
- p.Gln18Leu Single submitter ⚠
- p.Gln513Glu Single submitter ⚠
- p.Glu212Val Single submitter ⚠
- p.Glu251Gly Single submitter ⚠
- p.Glu28Val Single submitter ⚠
- p.Glu369Val Single submitter ⚠
- p.Glu54Val Single submitter ⚠
- p.Glu581Lys Single submitter ⚠
- p.Glu59Val Single submitter ⚠
- p.Gly293Trp Single submitter ⚠
- p.Gly508Asp Single submitter ⚠
- p.Gly547Ala Single submitter ⚠
- p.Gly572Glu Single submitter ⚠
- p.Gly646Asp Single submitter ⚠
- p.His133Arg Single submitter ⚠
- p.His328Tyr Single submitter ⚠
- p.His356Tyr Single submitter ⚠
- p.His494Arg Single submitter ⚠
- p.Ile208Phe Single submitter ⚠
- p.Ile325Thr Single submitter ⚠
- p.Ile359Thr Single submitter ⚠
- p.Ile503Val Single submitter ⚠
- p.Ile550Leu Single submitter ⚠
- p.Ile558Val Single submitter ⚠
- p.Ile583Thr Single submitter ⚠
- p.Ile647Met Single submitter ⚠
- p.Ile659Met Single submitter ⚠
- p.Ile659Thr Single submitter ⚠
- p.Leu238Ser Single submitter ⚠
- p.Leu600Phe Single submitter ⚠
- p.Lys419Thr Single submitter ⚠
- p.Lys80Glu Single submitter ⚠
- p.Met150Lys Single submitter ⚠
- p.Met563Val Single submitter ⚠
- p.Phe110Ile Single submitter ⚠
- p.Phe110Leu Single submitter ⚠
- p.Phe367Leu Single submitter ⚠
- p.Phe367Tyr Single submitter ⚠
- p.Phe399Ser Single submitter ⚠
- p.Pro122Ala Single submitter ⚠
- p.Pro13Thr Single submitter ⚠
- p.Pro628Ser Single submitter ⚠
- p.Pro7Ser Single submitter ⚠
- p.Pro92Ser Single submitter ⚠
- p.Pro96Ser Single submitter ⚠
- p.Ser103Thr Single submitter ⚠
- p.Ser123Thr Single submitter ⚠
- p.Ser167Leu Single submitter ⚠
- p.Ser368Phe Single submitter ⚠
- p.Ser490Thr Single submitter ⚠
- p.Ser599Ile Single submitter ⚠
- p.Ser635Phe Single submitter ⚠
- p.Ser8Arg Single submitter ⚠
- p.Thr467Ile Single submitter ⚠
- p.Tyr493Cys Single submitter ⚠
- p.Tyr510Cys Single submitter ⚠
- p.Tyr588Phe Single submitter ⚠
- p.Tyr630Cys Single submitter ⚠
- p.Tyr77Asp Single submitter ⚠
- p.Val182Gly Single submitter ⚠
- p.Val182Leu Single submitter ⚠
- p.Val335Ala Single submitter ⚠
- p.Val396Ala Single submitter ⚠
- p.Val463Ala Single submitter ⚠
- p.Val548Ala Single submitter ⚠
- p.Val575Gly Single submitter ⚠
- p.Val589Ile Single submitter ⚠
- p.Val81Phe Single submitter ⚠