ERV3-1 — 2 ClinVar variants
All ClinVar germline ERV3-1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 1 flagged for review →
1 Benign · 1 Uncertain significance
Full ERV3-1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 1
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 1
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
All ERV3-1 variants
Benign 1
- p.Gly566= Multiple submitters
Uncertain significance 1
- p.Ile587Val Single submitter ⚠