ERVV-1 — 57 ClinVar variants
All ClinVar germline ERVV-1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 52 flagged for review →
5 Likely benign · 52 Uncertain significance
Full ERVV-1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 52
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 35
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ERVV-1 p.Ala331Val Uncertain significance Single submitter
- ERVV-1 p.Ala337Ser Uncertain significance Single submitter
- ERVV-1 p.Ala337Thr Uncertain significance Single submitter
- ERVV-1 p.Ala372Val Uncertain significance Single submitter
- ERVV-1 p.Arg175Gln Uncertain significance Single submitter
- ERVV-1 p.Arg246Gln Uncertain significance Single submitter
- ERVV-1 p.Arg304Gln Uncertain significance Single submitter
- ERVV-1 p.Arg304Leu Uncertain significance Single submitter
- ERVV-1 p.Asn106Ser Uncertain significance Single submitter
- ERVV-1 p.Asn49Ser Uncertain significance Single submitter
- ERVV-1 p.Asp134Asn Uncertain significance Single submitter
- ERVV-1 p.Gln226Pro Uncertain significance Single submitter
- ERVV-1 p.Gln318Glu Uncertain significance Single submitter
- ERVV-1 p.Gln355Glu Uncertain significance Single submitter
- ERVV-1 p.Gly323Ser Uncertain significance Single submitter
- ERVV-1 p.Ile273Leu Uncertain significance Single submitter
- ERVV-1 p.Ile273Val Uncertain significance Single submitter
- ERVV-1 p.Ile306Leu Uncertain significance Single submitter
- ERVV-1 p.Ile306Met Uncertain significance Single submitter
- ERVV-1 p.Ile51Val Uncertain significance Single submitter
- ERVV-1 p.Leu28Phe Uncertain significance Single submitter
- ERVV-1 p.Leu324Ile Uncertain significance Single submitter
- ERVV-1 p.Lys33Arg Uncertain significance Single submitter
- ERVV-1 p.Met151Arg Uncertain significance Single submitter
- ERVV-1 p.Met151Lys Uncertain significance Single submitter
- ERVV-1 p.Pro207Ser Uncertain significance Single submitter
- ERVV-1 p.Pro84Leu Uncertain significance Single submitter
- ERVV-1 p.Ser145Gly Uncertain significance Single submitter
- ERVV-1 p.Ser212Pro Uncertain significance Single submitter
- ERVV-1 p.Ser234Leu Uncertain significance Single submitter
- ERVV-1 p.Ser242Asn Uncertain significance Single submitter
- ERVV-1 p.Tyr311Asn Uncertain significance Single submitter
- ERVV-1 p.Tyr59Asn Uncertain significance Single submitter
- ERVV-1 p.Val206Ile Uncertain significance Single submitter
- ERVV-1 p.Val214Ile Uncertain significance Single submitter
Predictors split 17
The independent predictors disagree with each other — read with care.
- ERVV-1 p.Arg195Ser Uncertain significance Single submitter
- ERVV-1 p.Cys224Arg Uncertain significance Single submitter
- ERVV-1 p.Cys249Ser Uncertain significance Single submitter
- ERVV-1 p.Gly294Ala Uncertain significance Single submitter
- ERVV-1 p.Gly302Arg Uncertain significance Single submitter
- ERVV-1 p.Gly302Glu Uncertain significance Single submitter
- ERVV-1 p.Gly307Asp Uncertain significance Single submitter
- ERVV-1 p.Gly330Ser Uncertain significance Single submitter
- ERVV-1 p.Gly72Cys Uncertain significance Single submitter
- ERVV-1 p.His292Arg Uncertain significance Single submitter
- ERVV-1 p.His48Arg Uncertain significance Single submitter
- ERVV-1 p.Leu236Ser Uncertain significance Single submitter
- ERVV-1 p.Pro251Arg Uncertain significance Single submitter
- ERVV-1 p.Pro251Thr Uncertain significance Single submitter
- ERVV-1 p.Thr293Met Uncertain significance Single submitter
- ERVV-1 p.Trp209Cys Uncertain significance Single submitter
- ERVV-1 p.Tyr254Cys Uncertain significance Single submitter
All ERVV-1 variants
Likely benign 5
- p.Ala223Thr Single submitter
- p.Arg175= Single submitter
- p.Arg53Lys Single submitter
- p.Ile60= Single submitter
- p.Lys262Gln Single submitter
Uncertain significance 52
- p.Ala331Val Single submitter ⚠
- p.Ala337Ser Single submitter ⚠
- p.Ala337Thr Single submitter ⚠
- p.Ala372Val Single submitter ⚠
- p.Arg175Gln Single submitter ⚠
- p.Arg195Ser Single submitter ⚠
- p.Arg246Gln Single submitter ⚠
- p.Arg304Gln Single submitter ⚠
- p.Arg304Leu Single submitter ⚠
- p.Asn106Ser Single submitter ⚠
- p.Asn49Ser Single submitter ⚠
- p.Asp134Asn Single submitter ⚠
- p.Cys224Arg Single submitter ⚠
- p.Cys249Ser Single submitter ⚠
- p.Gln226Pro Single submitter ⚠
- p.Gln318Glu Single submitter ⚠
- p.Gln355Glu Single submitter ⚠
- p.Gly294Ala Single submitter ⚠
- p.Gly302Arg Single submitter ⚠
- p.Gly302Glu Single submitter ⚠
- p.Gly307Asp Single submitter ⚠
- p.Gly323Ser Single submitter ⚠
- p.Gly330Ser Single submitter ⚠
- p.Gly72Cys Single submitter ⚠
- p.His292Arg Single submitter ⚠
- p.His48Arg Single submitter ⚠
- p.Ile273Leu Single submitter ⚠
- p.Ile273Val Single submitter ⚠
- p.Ile306Leu Single submitter ⚠
- p.Ile306Met Single submitter ⚠
- p.Ile51Val Single submitter ⚠
- p.Leu236Ser Single submitter ⚠
- p.Leu28Phe Single submitter ⚠
- p.Leu324Ile Single submitter ⚠
- p.Lys33Arg Single submitter ⚠
- p.Met151Arg Single submitter ⚠
- p.Met151Lys Single submitter ⚠
- p.Pro207Ser Single submitter ⚠
- p.Pro251Arg Single submitter ⚠
- p.Pro251Thr Single submitter ⚠
- p.Pro84Leu Single submitter ⚠
- p.Ser145Gly Single submitter ⚠
- p.Ser212Pro Single submitter ⚠
- p.Ser234Leu Single submitter ⚠
- p.Ser242Asn Single submitter ⚠
- p.Thr293Met Single submitter ⚠
- p.Trp209Cys Single submitter ⚠
- p.Tyr254Cys Single submitter ⚠
- p.Tyr311Asn Single submitter ⚠
- p.Tyr59Asn Single submitter ⚠
- p.Val206Ile Single submitter ⚠
- p.Val214Ile Single submitter ⚠