ERVV-2 — 57 ClinVar variants
All ClinVar germline ERVV-2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 53 flagged for review →
4 Likely benign · 53 Uncertain significance
Full ERVV-2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 53
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 37
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ERVV-2 p.Ala337Thr Uncertain significance Single submitter
- ERVV-2 p.Ala442Ser Uncertain significance Single submitter
- ERVV-2 p.Ala450Thr Uncertain significance Single submitter
- ERVV-2 p.Arg304Gln Uncertain significance Single submitter
- ERVV-2 p.Arg304Gly Uncertain significance Single submitter
- ERVV-2 p.Arg441Gly Uncertain significance Single submitter
- ERVV-2 p.Arg441Lys Uncertain significance Single submitter
- ERVV-2 p.Arg527Gln Uncertain significance Single submitter
- ERVV-2 p.Asn49Ser Uncertain significance Single submitter
- ERVV-2 p.Asp520Glu Uncertain significance Single submitter
- ERVV-2 p.Asp520Val Uncertain significance Single submitter
- ERVV-2 p.Gln107Glu Uncertain significance Single submitter
- ERVV-2 p.Gln261His Uncertain significance Single submitter
- ERVV-2 p.Gln318Glu Uncertain significance Single submitter
- ERVV-2 p.Gln491Arg Uncertain significance Single submitter
- ERVV-2 p.Glu3Asp Uncertain significance Single submitter
- ERVV-2 p.Glu500Gly Uncertain significance Single submitter
- ERVV-2 p.Glu528Gln Uncertain significance Single submitter
- ERVV-2 p.Glu532Lys Uncertain significance Single submitter
- ERVV-2 p.His237Gln Uncertain significance Single submitter
- ERVV-2 p.Ile287Leu Uncertain significance Single submitter
- ERVV-2 p.Ile507Val Uncertain significance Single submitter
- ERVV-2 p.Leu257Phe Uncertain significance Single submitter
- ERVV-2 p.Leu28Ile Uncertain significance Single submitter
- ERVV-2 p.Leu324Ile Uncertain significance Single submitter
- ERVV-2 p.Lys262Gln Uncertain significance Single submitter
- ERVV-2 p.Lys264Thr Uncertain significance Single submitter
- ERVV-2 p.Met151Val Uncertain significance Single submitter
- ERVV-2 p.Met171Ile Uncertain significance Single submitter
- ERVV-2 p.Pro251Ala Uncertain significance Single submitter
- ERVV-2 p.Pro338Leu Uncertain significance Single submitter
- ERVV-2 p.Pro518Leu Uncertain significance Single submitter
- ERVV-2 p.Thr208Pro Uncertain significance Single submitter
- ERVV-2 p.Tyr174Cys Uncertain significance Single submitter
- ERVV-2 p.Val347Ile Uncertain significance Single submitter
- ERVV-2 p.Val458Ile Uncertain significance Single submitter
- ERVV-2 p.Val485Phe Uncertain significance Single submitter
Predictors split 16
The independent predictors disagree with each other — read with care.
- ERVV-2 p.Arg195Ser Uncertain significance Single submitter
- ERVV-2 p.Asn39Lys Uncertain significance Single submitter
- ERVV-2 p.Asn403Ser Uncertain significance Single submitter
- ERVV-2 p.Cys118Phe Uncertain significance Single submitter
- ERVV-2 p.Cys249Arg Uncertain significance Single submitter
- ERVV-2 p.Cys249Ser Uncertain significance Single submitter
- ERVV-2 p.Cys484Tyr Uncertain significance Single submitter
- ERVV-2 p.Cys98Phe Uncertain significance Single submitter
- ERVV-2 p.His48Arg Uncertain significance Single submitter
- ERVV-2 p.Leu265Arg Uncertain significance Single submitter
- ERVV-2 p.Leu28Pro Uncertain significance Single submitter
- ERVV-2 p.Leu472Pro Uncertain significance Single submitter
- ERVV-2 p.Lys483Glu Uncertain significance Single submitter
- ERVV-2 p.Phe492Leu Uncertain significance Single submitter
- ERVV-2 p.Phe526Leu Uncertain significance Single submitter
- ERVV-2 p.Thr293Met Uncertain significance Single submitter
All ERVV-2 variants
Likely benign 4
- p.Asp357Glu Single submitter
- p.Ile60= Single submitter
- p.Pro279Ala Single submitter
- p.Ser37Leu Single submitter
Uncertain significance 53
- p.Ala337Thr Single submitter ⚠
- p.Ala442Ser Single submitter ⚠
- p.Ala450Thr Single submitter ⚠
- p.Arg195Ser Single submitter ⚠
- p.Arg304Gln Single submitter ⚠
- p.Arg304Gly Single submitter ⚠
- p.Arg441Gly Single submitter ⚠
- p.Arg441Lys Single submitter ⚠
- p.Arg527Gln Single submitter ⚠
- p.Asn39Lys Single submitter ⚠
- p.Asn403Ser Single submitter ⚠
- p.Asn49Ser Single submitter ⚠
- p.Asp520Glu Single submitter ⚠
- p.Asp520Val Single submitter ⚠
- p.Cys118Phe Single submitter ⚠
- p.Cys249Arg Single submitter ⚠
- p.Cys249Ser Single submitter ⚠
- p.Cys484Tyr Single submitter ⚠
- p.Cys98Phe Single submitter ⚠
- p.Gln107Glu Single submitter ⚠
- p.Gln261His Single submitter ⚠
- p.Gln318Glu Single submitter ⚠
- p.Gln491Arg Single submitter ⚠
- p.Glu3Asp Single submitter ⚠
- p.Glu500Gly Single submitter ⚠
- p.Glu528Gln Single submitter ⚠
- p.Glu532Lys Single submitter ⚠
- p.His237Gln Single submitter ⚠
- p.His48Arg Single submitter ⚠
- p.Ile287Leu Single submitter ⚠
- p.Ile507Val Single submitter ⚠
- p.Leu257Phe Single submitter ⚠
- p.Leu265Arg Single submitter ⚠
- p.Leu28Ile Single submitter ⚠
- p.Leu28Pro Single submitter ⚠
- p.Leu324Ile Single submitter ⚠
- p.Leu472Pro Single submitter ⚠
- p.Lys262Gln Single submitter ⚠
- p.Lys264Thr Single submitter ⚠
- p.Lys483Glu Single submitter ⚠
- p.Met151Val Single submitter ⚠
- p.Met171Ile Single submitter ⚠
- p.Phe492Leu Single submitter ⚠
- p.Phe526Leu Single submitter ⚠
- p.Pro251Ala Single submitter ⚠
- p.Pro338Leu Single submitter ⚠
- p.Pro518Leu Single submitter ⚠
- p.Thr208Pro Single submitter ⚠
- p.Thr293Met Single submitter ⚠
- p.Tyr174Cys Single submitter ⚠
- p.Val347Ile Single submitter ⚠
- p.Val458Ile Single submitter ⚠
- p.Val485Phe Single submitter ⚠