EXOC3 — 115 ClinVar variants
All ClinVar germline EXOC3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 103 flagged for review →
3 Benign · 3 Likely benign · 109 Uncertain significance
Full EXOC3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 103
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 86
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- EXOC3 p.Ala137Val Uncertain significance Single submitter
- EXOC3 p.Ala318Ser Uncertain significance Single submitter
- EXOC3 p.Ala37Val Uncertain significance Single submitter
- EXOC3 p.Ala469Val Uncertain significance Single submitter
- EXOC3 p.Ala533Thr Uncertain significance Single submitter
- EXOC3 p.Ala568Val Uncertain significance Single submitter
- EXOC3 p.Ala609Glu Uncertain significance Single submitter
- EXOC3 p.Arg127Lys Uncertain significance Single submitter
- EXOC3 p.Arg143Gln Uncertain significance Single submitter
- EXOC3 p.Arg152Trp Uncertain significance Single submitter
- EXOC3 p.Arg225Cys Uncertain significance Single submitter
- EXOC3 p.Arg225His Uncertain significance Single submitter
- EXOC3 p.Arg38Trp Uncertain significance Single submitter
- EXOC3 p.Arg396Trp Uncertain significance Single submitter
- EXOC3 p.Arg632Ser Uncertain significance Single submitter
- EXOC3 p.Arg638Cys Uncertain significance Single submitter
- EXOC3 p.Arg638Gly Uncertain significance Single submitter
- EXOC3 p.Asn334Ser Uncertain significance Single submitter
- EXOC3 p.Asn581Ser Uncertain significance Single submitter
- EXOC3 p.Asp271Glu Uncertain significance Single submitter
- EXOC3 p.Asp651Glu Uncertain significance Single submitter
- EXOC3 p.Asp657His Uncertain significance Single submitter
- EXOC3 p.Asp706Glu Uncertain significance Single submitter
- EXOC3 p.Cys656Ser Uncertain significance Single submitter
- EXOC3 p.Glu246Lys Uncertain significance Single submitter
- EXOC3 p.Glu329Asp Uncertain significance Single submitter
- EXOC3 p.Glu357Val Uncertain significance Single submitter
- EXOC3 p.Glu517Asp Uncertain significance Single submitter
- EXOC3 p.Glu621Gly Uncertain significance Single submitter
- EXOC3 p.Glu713Gly Uncertain significance Single submitter
- EXOC3 p.Glu7Asp Uncertain significance Single submitter
- EXOC3 p.Gly529Glu Uncertain significance Single submitter
- EXOC3 p.Gly538Ala Uncertain significance Single submitter
- EXOC3 p.Gly541Arg Uncertain significance Single submitter
- EXOC3 p.Gly649Arg Uncertain significance Single submitter
- EXOC3 p.His278Tyr Uncertain significance Single submitter
- EXOC3 p.Ile222Val Uncertain significance Single submitter
- EXOC3 p.Ile291Thr Uncertain significance Single submitter
- EXOC3 p.Ile733Val Uncertain significance Single submitter
- EXOC3 p.Leu331Pro Uncertain significance Single submitter
- EXOC3 p.Leu371Ile Uncertain significance Single submitter
- EXOC3 p.Leu455Phe Uncertain significance Single submitter
- EXOC3 p.Leu738Val Uncertain significance Single submitter
- EXOC3 p.Lys245Asn Uncertain significance Single submitter
- EXOC3 p.Lys97Arg Uncertain significance Single submitter
- EXOC3 p.Pro525Thr Uncertain significance Single submitter
- EXOC3 p.Pro736Ser Uncertain significance Single submitter
- EXOC3 p.Ser179Asn Uncertain significance Single submitter
- EXOC3 p.Ser443Thr Uncertain significance Single submitter
- EXOC3 p.Ser463Asn Uncertain significance Single submitter
- EXOC3 p.Ser506Gly Uncertain significance Single submitter
- EXOC3 p.Ser540Asn Uncertain significance Single submitter
- EXOC3 p.Thr167Ala Uncertain significance Single submitter
- EXOC3 p.Thr167Met Uncertain significance Single submitter
- EXOC3 p.Thr207Ala Uncertain significance Single submitter
- EXOC3 p.Thr257Ala Uncertain significance Single submitter
- EXOC3 p.Thr267Ser Uncertain significance Single submitter
- EXOC3 p.Thr321Met Uncertain significance Single submitter
- EXOC3 p.Thr341Met Uncertain significance Single submitter
- EXOC3 p.Thr350Ile Uncertain significance Single submitter
- EXOC3 p.Thr366Asn Uncertain significance Single submitter
- EXOC3 p.Thr382Met Uncertain significance Single submitter
- EXOC3 p.Thr388Asn Uncertain significance Single submitter
- EXOC3 p.Thr60Ala Uncertain significance Single submitter
- EXOC3 p.Thr714Ala Uncertain significance Single submitter
- EXOC3 p.Trp342Ser Uncertain significance Single submitter
- EXOC3 p.Trp394Gly Uncertain significance Single submitter
- EXOC3 p.Tyr305Cys Uncertain significance Single submitter
- EXOC3 p.Tyr305His Uncertain significance Single submitter
- EXOC3 p.Val113Met Uncertain significance Single submitter
- EXOC3 p.Val200Ala Uncertain significance Single submitter
- EXOC3 p.Val236Leu Uncertain significance Single submitter
- EXOC3 p.Val236Phe Uncertain significance Single submitter
- EXOC3 p.Val356Leu Uncertain significance Single submitter
- EXOC3 p.Val450Ile Uncertain significance Single submitter
- EXOC3 p.Val487Ile Uncertain significance Single submitter
- EXOC3 p.Val576Met Uncertain significance Single submitter
- EXOC3 p.Val602Ala Uncertain significance Single submitter
- EXOC3 p.Val602Leu Uncertain significance Single submitter
- EXOC3 p.Val662Met Uncertain significance Single submitter
- EXOC3 p.Val699Leu Uncertain significance Single submitter
- EXOC3 p.Val727Leu Uncertain significance Single submitter
- EXOC3 p.Val727Met Uncertain significance Single submitter
- EXOC3 p.Val72Ile Uncertain significance Single submitter
- EXOC3 p.Val740Met Uncertain significance Single submitter
- EXOC3 p.Val9Ile Uncertain significance Single submitter
Predictors split 17
The independent predictors disagree with each other — read with care.
- EXOC3 p.Pro303Arg Benign Multiple submitters
- EXOC3 p.Ala333Thr Uncertain significance Single submitter
- EXOC3 p.Ala609Thr Uncertain significance Single submitter
- EXOC3 p.Ala627Thr Uncertain significance Single submitter
- EXOC3 p.Arg22Cys Uncertain significance Single submitter
- EXOC3 p.Arg600Trp Uncertain significance Single submitter
- EXOC3 p.Arg601Cys Uncertain significance Single submitter
- EXOC3 p.Arg6Trp Uncertain significance Single submitter
- EXOC3 p.Asp415Asn Uncertain significance Single submitter
- EXOC3 p.Asp415Glu Uncertain significance Single submitter
- EXOC3 p.Glu400Gln Uncertain significance Single submitter
- EXOC3 p.Glu635Val Uncertain significance Single submitter
- EXOC3 p.His599Asp Uncertain significance Single submitter
- EXOC3 p.Lys587Glu Uncertain significance Single submitter
- EXOC3 p.Met19Ile Uncertain significance Single submitter
- EXOC3 p.Ser443Ile Uncertain significance Single submitter
- EXOC3 p.Tyr472His Uncertain significance Single submitter
All EXOC3 variants
Benign 3
- p.Pro303Arg Multiple submitters ⚠
- p.Ser42= Multiple submitters
- p.Ser78= Multiple submitters
Likely benign 3
- p.Arg593= Single submitter
- p.Gly541Ser Single submitter
- p.Thr350Ala Single submitter
Uncertain significance 109
- p.Ala137Val Single submitter ⚠
- p.Ala318Ser Single submitter ⚠
- p.Ala333Thr Single submitter ⚠
- p.Ala37Val Single submitter ⚠
- p.Ala469Val Single submitter ⚠
- p.Ala533Thr Single submitter ⚠
- p.Ala568Val Single submitter ⚠
- p.Ala609Glu Single submitter ⚠
- p.Ala609Thr Single submitter ⚠
- p.Ala627Thr Single submitter ⚠
- p.Arg127Lys Single submitter ⚠
- p.Arg143Gln Single submitter ⚠
- p.Arg152Gln Single submitter
- p.Arg152Trp Single submitter ⚠
- p.Arg225Cys Single submitter ⚠
- p.Arg225His Single submitter ⚠
- p.Arg22Cys Single submitter ⚠
- p.Arg277His Single submitter
- p.Arg38Trp Single submitter ⚠
- p.Arg396Trp Single submitter ⚠
- p.Arg600Trp Single submitter ⚠
- p.Arg601Cys Single submitter ⚠
- p.Arg632Ser Single submitter ⚠
- p.Arg638Cys Single submitter ⚠
- p.Arg638Gly Single submitter ⚠
- p.Arg6Trp Single submitter ⚠
- p.Asn334Ser Single submitter ⚠
- p.Asn581Ser Single submitter ⚠
- p.Asp271Glu Single submitter ⚠
- p.Asp415Asn Single submitter ⚠
- p.Asp415Glu Single submitter ⚠
- p.Asp651Glu Single submitter ⚠
- p.Asp657His Single submitter ⚠
- p.Asp706Glu Single submitter ⚠
- p.Cys300Ter Single submitter
- p.Cys656Ser Single submitter ⚠
- p.Glu246Lys Single submitter ⚠
- p.Glu329Asp Single submitter ⚠
- p.Glu357Val Single submitter ⚠
- p.Glu400Gln Single submitter ⚠
- p.Glu517Asp Single submitter ⚠
- p.Glu621Gly Single submitter ⚠
- p.Glu635Val Single submitter ⚠
- p.Glu713Gly Single submitter ⚠
- p.Glu7Asp Single submitter ⚠
- p.Gly529Glu Single submitter ⚠
- p.Gly538Ala Single submitter ⚠
- p.Gly541Arg Single submitter ⚠
- p.Gly649Arg Single submitter ⚠
- p.His278Tyr Single submitter ⚠
- p.His599Asp Single submitter ⚠
- p.Ile133Thr Single submitter
- p.Ile222Val Single submitter ⚠
- p.Ile291Thr Single submitter ⚠
- p.Ile307Ser Single submitter
- p.Ile733Val Single submitter ⚠
- p.Leu331Pro Single submitter ⚠
- p.Leu371Ile Single submitter ⚠
- p.Leu455Phe Single submitter ⚠
- p.Leu564Ter Single submitter
- p.Leu738Val Single submitter ⚠
- p.Lys245Asn Single submitter ⚠
- p.Lys587Glu Single submitter ⚠
- p.Lys97Arg Single submitter ⚠
- p.Met19Ile Single submitter ⚠
- p.Pro525Thr Single submitter ⚠
- p.Pro736Ser Single submitter ⚠
- p.Ser179Asn Single submitter ⚠
- p.Ser443Ile Single submitter ⚠
- p.Ser443Thr Single submitter ⚠
- p.Ser463Asn Single submitter ⚠
- p.Ser506Gly Single submitter ⚠
- p.Ser540Asn Single submitter ⚠
- p.Thr167Ala Single submitter ⚠
- p.Thr167Met Single submitter ⚠
- p.Thr207Ala Single submitter ⚠
- p.Thr257Ala Single submitter ⚠
- p.Thr267Ser Single submitter ⚠
- p.Thr321Met Single submitter ⚠
- p.Thr341Met Single submitter ⚠
- p.Thr350Ile Single submitter ⚠
- p.Thr366Asn Single submitter ⚠
- p.Thr382Met Single submitter ⚠
- p.Thr388Asn Single submitter ⚠
- p.Thr60Ala Single submitter ⚠
- p.Thr714Ala Single submitter ⚠
- p.Trp342Ser Single submitter ⚠
- p.Trp394Gly Single submitter ⚠
- p.Tyr305Cys Single submitter ⚠
- p.Tyr305His Single submitter ⚠
- p.Tyr472His Single submitter ⚠
- p.Val113Met Single submitter ⚠
- p.Val200Ala Single submitter ⚠
- p.Val236Leu Single submitter ⚠
- p.Val236Phe Single submitter ⚠
- p.Val343Ala Single submitter
- p.Val356Leu Single submitter ⚠
- p.Val450Ile Single submitter ⚠
- p.Val487Ile Single submitter ⚠
- p.Val576Met Single submitter ⚠
- p.Val602Ala Single submitter ⚠
- p.Val602Leu Single submitter ⚠
- p.Val662Met Single submitter ⚠
- p.Val699Leu Single submitter ⚠
- p.Val727Leu Single submitter ⚠
- p.Val727Met Single submitter ⚠
- p.Val72Ile Single submitter ⚠
- p.Val740Met Single submitter ⚠
- p.Val9Ile Single submitter ⚠