EXOSC10 — 116 ClinVar variants
All ClinVar germline EXOSC10 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 109 flagged for review →
1 Benign · 4 Likely benign · 111 Uncertain significance
Full EXOSC10 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 109
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 94
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- EXOSC10 p.Ala576Thr Uncertain significance Single submitter
- EXOSC10 p.Ala681Thr Uncertain significance Single submitter
- EXOSC10 p.Ala764Val Uncertain significance Single submitter
- EXOSC10 p.Arg100Gly Uncertain significance Single submitter
- EXOSC10 p.Arg173Gln Uncertain significance Single submitter
- EXOSC10 p.Arg188Pro Uncertain significance Single submitter
- EXOSC10 p.Arg227Cys Uncertain significance Single submitter
- EXOSC10 p.Arg334Trp Uncertain significance Single submitter
- EXOSC10 p.Arg458His Uncertain significance Single submitter
- EXOSC10 p.Arg64Gln Uncertain significance Single submitter
- EXOSC10 p.Arg702Cys Uncertain significance Single submitter
- EXOSC10 p.Arg723His Uncertain significance Single submitter
- EXOSC10 p.Arg94His Uncertain significance Single submitter
- EXOSC10 p.Asn263Thr Uncertain significance Single submitter
- EXOSC10 p.Asn460Ser Uncertain significance Single submitter
- EXOSC10 p.Asn645Lys Uncertain significance Single submitter
- EXOSC10 p.Asn881Ser Uncertain significance Single submitter
- EXOSC10 p.Asp21His Uncertain significance Single submitter
- EXOSC10 p.Asp475Asn Uncertain significance Single submitter
- EXOSC10 p.Asp786Asn Uncertain significance Single submitter
- EXOSC10 p.Cys852Tyr Uncertain significance Single submitter
- EXOSC10 p.Cys93Phe Uncertain significance Single submitter
- EXOSC10 p.Gln147His Uncertain significance Single submitter
- EXOSC10 p.Gln505Arg Uncertain significance Single submitter
- EXOSC10 p.Gln707Glu Uncertain significance Single submitter
- EXOSC10 p.Glu284Gln Uncertain significance Single submitter
- EXOSC10 p.Glu302Gln Uncertain significance Single submitter
- EXOSC10 p.Glu302Lys Uncertain significance Single submitter
- EXOSC10 p.Glu354Asp Uncertain significance Single submitter
- EXOSC10 p.Glu431Gly Uncertain significance Single submitter
- EXOSC10 p.Glu431Lys Uncertain significance Single submitter
- EXOSC10 p.Glu686Gln Uncertain significance Single submitter
- EXOSC10 p.Glu781Gln Uncertain significance Single submitter
- EXOSC10 p.Gly125Ser Uncertain significance Single submitter
- EXOSC10 p.Gly380Val Uncertain significance Single submitter
- EXOSC10 p.Gly459Ser Uncertain significance Single submitter
- EXOSC10 p.Gly589Arg Uncertain significance Single submitter
- EXOSC10 p.Gly872Arg Uncertain significance Single submitter
- EXOSC10 p.His242Tyr Uncertain significance Single submitter
- EXOSC10 p.His390Tyr Uncertain significance Single submitter
- EXOSC10 p.His701Arg Uncertain significance Single submitter
- EXOSC10 p.Ile180Val Uncertain significance Single submitter
- EXOSC10 p.Ile485Val Uncertain significance Single submitter
- EXOSC10 p.Ile623Thr Uncertain significance Single submitter
- EXOSC10 p.Leu142Phe Uncertain significance Single submitter
- EXOSC10 p.Leu146Phe Uncertain significance Single submitter
- EXOSC10 p.Leu272Ile Uncertain significance Single submitter
- EXOSC10 p.Leu602Met Uncertain significance Single submitter
- EXOSC10 p.Leu647Pro Uncertain significance Single submitter
- EXOSC10 p.Leu660Ser Uncertain significance Single submitter
- EXOSC10 p.Lys136Gln Uncertain significance Single submitter
- EXOSC10 p.Lys168Asn Uncertain significance Single submitter
- EXOSC10 p.Lys758Arg Uncertain significance Single submitter
- EXOSC10 p.Lys813Glu Uncertain significance Single submitter
- EXOSC10 p.Lys835Arg Uncertain significance Single submitter
- EXOSC10 p.Lys865Gln Uncertain significance Single submitter
- EXOSC10 p.Phe825Val Uncertain significance Single submitter
- EXOSC10 p.Pro149Ser Uncertain significance Single submitter
- EXOSC10 p.Pro235Ala Uncertain significance Single submitter
- EXOSC10 p.Pro282Arg Uncertain significance Single submitter
- EXOSC10 p.Pro54Leu Uncertain significance Single submitter
- EXOSC10 p.Pro557Ser Uncertain significance Single submitter
- EXOSC10 p.Pro617Leu Uncertain significance Single submitter
- EXOSC10 p.Pro630Ala Uncertain significance Single submitter
- EXOSC10 p.Pro630Leu Uncertain significance Single submitter
- EXOSC10 p.Pro704Ala Uncertain significance Single submitter
- EXOSC10 p.Pro817Ala Uncertain significance Single submitter
- EXOSC10 p.Ser321Thr Uncertain significance Single submitter
- EXOSC10 p.Ser347Gly Uncertain significance Single submitter
- EXOSC10 p.Ser473Asn Uncertain significance Single submitter
- EXOSC10 p.Ser5Gly Uncertain significance Single submitter
- EXOSC10 p.Ser698Leu Uncertain significance Single submitter
- EXOSC10 p.Ser866Gly Uncertain significance Single submitter
- EXOSC10 p.Thr342Ala Uncertain significance Single submitter
- EXOSC10 p.Thr659Met Uncertain significance Single submitter
- EXOSC10 p.Thr659Ser Uncertain significance Single submitter
- EXOSC10 p.Thr6Ala Uncertain significance Single submitter
- EXOSC10 p.Thr747Arg Uncertain significance Single submitter
- EXOSC10 p.Thr789Ile Uncertain significance Single submitter
- EXOSC10 p.Thr816Met Uncertain significance Single submitter
- EXOSC10 p.Tyr280His Uncertain significance Single submitter
- EXOSC10 p.Tyr382Phe Uncertain significance Single submitter
- EXOSC10 p.Tyr446His Uncertain significance Single submitter
- EXOSC10 p.Tyr90Phe Uncertain significance Single submitter
- EXOSC10 p.Val233Ile Uncertain significance Single submitter
- EXOSC10 p.Val25Leu Uncertain significance Single submitter
- EXOSC10 p.Val298Met Uncertain significance Single submitter
- EXOSC10 p.Val364Ile Uncertain significance Single submitter
- EXOSC10 p.Val43Met Uncertain significance Single submitter
- EXOSC10 p.Val464Met Uncertain significance Single submitter
- EXOSC10 p.Val590Met Uncertain significance Single submitter
- EXOSC10 p.Val767Ile Uncertain significance Single submitter
- EXOSC10 p.Val772Leu Uncertain significance Single submitter
- EXOSC10 p.Val87Glu Uncertain significance Single submitter
Predictors split 15
The independent predictors disagree with each other — read with care.
- EXOSC10 p.Arg472Trp Uncertain significance Single submitter
- EXOSC10 p.Arg577Gln Uncertain significance Single submitter
- EXOSC10 p.Asp33Tyr Uncertain significance Single submitter
- EXOSC10 p.Asp611His Uncertain significance Single submitter
- EXOSC10 p.Glu568Lys Uncertain significance Single submitter
- EXOSC10 p.Leu561Ile Uncertain significance Single submitter
- EXOSC10 p.Met386Val Uncertain significance Single submitter
- EXOSC10 p.Met694Thr Uncertain significance Single submitter
- EXOSC10 p.Phe29Cys Uncertain significance Single submitter
- EXOSC10 p.Phe310Leu Uncertain significance Single submitter
- EXOSC10 p.Pro67Leu Uncertain significance Single submitter
- EXOSC10 p.Thr171Ile Uncertain significance Single submitter
- EXOSC10 p.Tyr495Cys Uncertain significance Single submitter
- EXOSC10 p.Tyr90Asp Uncertain significance Single submitter
- EXOSC10 p.Val413Met Uncertain significance Single submitter
All EXOSC10 variants
Benign 1
- p.Leu343= Multiple submitters
Likely benign 4
- c.2157+7G>A Single submitter
- p.Ala760Thr Single submitter
- p.Arg768Gln Single submitter
- p.Thr715Ala Single submitter
Uncertain significance 111
- p.Ala576Thr Single submitter ⚠
- p.Ala681Thr Single submitter ⚠
- p.Ala764Val Single submitter ⚠
- p.Arg100Gly Single submitter ⚠
- p.Arg173Gln Single submitter ⚠
- p.Arg188Pro Single submitter ⚠
- p.Arg227Cys Single submitter ⚠
- p.Arg334Trp Single submitter ⚠
- p.Arg458His Single submitter ⚠
- p.Arg472Trp Single submitter ⚠
- p.Arg577Gln Single submitter ⚠
- p.Arg64Gln Single submitter ⚠
- p.Arg702Cys Single submitter ⚠
- p.Arg723His Single submitter ⚠
- p.Arg94His Single submitter ⚠
- p.Asn263Thr Single submitter ⚠
- p.Asn460Ser Single submitter ⚠
- p.Asn645Lys Single submitter ⚠
- p.Asn881Ser Single submitter ⚠
- p.Asp21His Single submitter ⚠
- p.Asp33Tyr Single submitter ⚠
- p.Asp475Asn Single submitter ⚠
- p.Asp611His Single submitter ⚠
- p.Asp786Asn Single submitter ⚠
- p.Cys852Tyr Single submitter ⚠
- p.Cys93Phe Single submitter ⚠
- p.Gln147His Single submitter ⚠
- p.Gln505Arg Single submitter ⚠
- p.Gln707Glu Single submitter ⚠
- p.Glu284Gln Single submitter ⚠
- p.Glu302Gln Single submitter ⚠
- p.Glu302Lys Single submitter ⚠
- p.Glu354Asp Single submitter ⚠
- p.Glu431Gly Single submitter ⚠
- p.Glu431Lys Single submitter ⚠
- p.Glu568Lys Single submitter ⚠
- p.Glu686Gln Single submitter ⚠
- p.Glu781Gln Single submitter ⚠
- p.Gly125Ser Single submitter ⚠
- p.Gly380Val Single submitter ⚠
- p.Gly459Ser Single submitter ⚠
- p.Gly589Arg Single submitter ⚠
- p.Gly872Arg Single submitter ⚠
- p.His242Tyr Single submitter ⚠
- p.His390Tyr Single submitter ⚠
- p.His701Arg Single submitter ⚠
- p.Ile180Val Single submitter ⚠
- p.Ile485Val Single submitter ⚠
- p.Ile623Thr Single submitter ⚠
- p.Leu142Phe Single submitter ⚠
- p.Leu146Phe Single submitter ⚠
- p.Leu272Ile Single submitter ⚠
- p.Leu561Ile Single submitter ⚠
- p.Leu602Met Single submitter ⚠
- p.Leu647Pro Single submitter ⚠
- p.Leu660Ser Single submitter ⚠
- p.Lys136Gln Single submitter ⚠
- p.Lys168Asn Single submitter ⚠
- p.Lys758Arg Single submitter ⚠
- p.Lys813Glu Single submitter ⚠
- p.Lys835Arg Single submitter ⚠
- p.Lys865Gln Single submitter ⚠
- p.Met349Thr Single submitter
- p.Met386Val Single submitter ⚠
- p.Met694Thr Single submitter ⚠
- p.Phe29Cys Single submitter ⚠
- p.Phe310Leu Single submitter ⚠
- p.Phe825Val Single submitter ⚠
- p.Pro149Ser Single submitter ⚠
- p.Pro235Ala Single submitter ⚠
- p.Pro282Arg Single submitter ⚠
- p.Pro54Leu Single submitter ⚠
- p.Pro557Ser Single submitter ⚠
- p.Pro617Leu Single submitter ⚠
- p.Pro630Ala Single submitter ⚠
- p.Pro630Leu Single submitter ⚠
- p.Pro67Leu Single submitter ⚠
- p.Pro704Ala Single submitter ⚠
- p.Pro817Ala Single submitter ⚠
- p.Ser321Thr Single submitter ⚠
- p.Ser347Gly Single submitter ⚠
- p.Ser473Asn Single submitter ⚠
- p.Ser5Gly Single submitter ⚠
- p.Ser698Leu Single submitter ⚠
- p.Ser866Gly Single submitter ⚠
- p.Thr171Ile Single submitter ⚠
- p.Thr342Ala Single submitter ⚠
- p.Thr47Ser Single submitter
- p.Thr659Met Single submitter ⚠
- p.Thr659Ser Single submitter ⚠
- p.Thr6Ala Single submitter ⚠
- p.Thr747Arg Single submitter ⚠
- p.Thr789Ile Single submitter ⚠
- p.Thr816Met Single submitter ⚠
- p.Tyr280His Single submitter ⚠
- p.Tyr382Phe Single submitter ⚠
- p.Tyr446His Single submitter ⚠
- p.Tyr495Cys Single submitter ⚠
- p.Tyr90Asp Single submitter ⚠
- p.Tyr90Phe Single submitter ⚠
- p.Val233Ile Single submitter ⚠
- p.Val25Leu Single submitter ⚠
- p.Val298Met Single submitter ⚠
- p.Val364Ile Single submitter ⚠
- p.Val413Met Single submitter ⚠
- p.Val43Met Single submitter ⚠
- p.Val464Met Single submitter ⚠
- p.Val590Met Single submitter ⚠
- p.Val767Ile Single submitter ⚠
- p.Val772Leu Single submitter ⚠
- p.Val87Glu Single submitter ⚠