Sugi Variant

Sugi Variant/F10

F10 — 160 ClinVar variants

All ClinVar germline F10 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 84 flagged for review →

19 Pathogenic · 25 Likely pathogenic · 9 Conflicting · 17 Benign · 5 Benign/Likely benign · 7 Likely benign · 78 Uncertain significance

Full F10 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 84

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors vs ClinVar 3

ClinVar calls these pathogenic, but the computational predictors lean tolerated — the highest-value review flag.

Predictors agree, ClinVar conflicts 5

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 48

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 28

The independent predictors disagree with each other — read with care.

All F10 variants

Pathogenic 19

Likely pathogenic 25

Conflicting classifications of pathogenicity 9

Benign 17

Benign/Likely benign 5

  • c.71-8C>T Multiple submitters congenital factor X deficiency
  • c.-40C>T Multiple submitters
  • p.Asn133= Multiple submitters congenital factor X deficiency
  • p.Asp132= Multiple submitters congenital factor X deficiency
  • p.Leu20= Multiple submitters

Likely benign 7

Uncertain significance 78