F2R — 51 ClinVar variants
All ClinVar germline F2R variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 41 flagged for review →
6 Benign · 2 Likely benign · 43 Uncertain significance
Full F2R gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 41
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 37
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- F2R p.Ala10Val Uncertain significance Single submitter
- F2R p.Ala203Thr Uncertain significance Single submitter
- F2R p.Ala268Ser Uncertain significance Single submitter
- F2R p.Arg214Ser Uncertain significance Single submitter
- F2R p.Arg5Trp Uncertain significance Single submitter
- F2R p.Asn49Lys Uncertain significance Single submitter
- F2R p.Asn75Lys Uncertain significance Single submitter
- F2R p.Asp393Asn Uncertain significance Single submitter
- F2R p.Cys223Ser Uncertain significance Single submitter
- F2R p.Cys387Arg Uncertain significance Single submitter
- F2R p.Gln209Arg Uncertain significance Single submitter
- F2R p.Glu264Lys Uncertain significance Single submitter
- F2R p.Gly165Ser Uncertain significance Single submitter
- F2R p.Ile121Val Uncertain significance Single submitter
- F2R p.Ile124Val Uncertain significance Single submitter
- F2R p.Ile198Met Uncertain significance Single submitter
- F2R p.Ile198Val Uncertain significance Single submitter
- F2R p.Leu103Val Uncertain significance Single submitter
- F2R p.Leu19Pro Uncertain significance Single submitter
- F2R p.Leu238Phe Uncertain significance Single submitter
- F2R p.Leu263Phe Uncertain significance Single submitter
- F2R p.Leu45Pro Uncertain significance Single submitter
- F2R p.Met122Leu Uncertain significance Single submitter
- F2R p.Pro118Arg Uncertain significance Single submitter
- F2R p.Ser21Tyr Uncertain significance Single submitter
- F2R p.Ser275Cys Uncertain significance Single submitter
- F2R p.Ser298Asn Uncertain significance Single submitter
- F2R p.Ser384Thr Uncertain significance Single submitter
- F2R p.Ser73Cys Uncertain significance Single submitter
- F2R p.Ser77Asn Uncertain significance Single submitter
- F2R p.Thr222Ile Uncertain significance Single submitter
- F2R p.Thr24Asn Uncertain significance Single submitter
- F2R p.Thr287Ala Uncertain significance Single submitter
- F2R p.Thr345Ala Uncertain significance Single submitter
- F2R p.Tyr353His Uncertain significance Single submitter
- F2R p.Val125Leu Uncertain significance Single submitter
- F2R p.Val154Ala Uncertain significance Single submitter
Predictors split 4
The independent predictors disagree with each other — read with care.
All F2R variants
Benign 6
Likely benign 2
- p.Tyr266= Single submitter
- p.Val133Ile Single submitter
Uncertain significance 43
- p.Ala10Val Single submitter ⚠
- p.Ala203Thr Single submitter ⚠
- p.Ala268Ser Single submitter ⚠
- p.Arg214Ser Single submitter ⚠
- p.Arg5Trp Single submitter ⚠
- p.Asn49Lys Single submitter ⚠
- p.Asn75Lys Single submitter ⚠
- p.Asp393Asn Single submitter ⚠
- p.Cys223Ser Single submitter ⚠
- p.Cys387Arg Single submitter ⚠
- p.Gln209Arg Single submitter ⚠
- p.Glu264Lys Single submitter ⚠
- p.Gly165Ser Single submitter ⚠
- p.Ile121Val Single submitter ⚠
- p.Ile124Val Single submitter ⚠
- p.Ile198Met Single submitter ⚠
- p.Ile198Val Single submitter ⚠
- p.Leu103Val Single submitter ⚠
- p.Leu19Pro Single submitter ⚠
- p.Leu238Phe Single submitter ⚠
- p.Leu258Phe Single submitter
- p.Leu263Phe Single submitter ⚠
- p.Leu45Pro Single submitter ⚠
- p.Lys422Asn Single submitter ⚠
- p.Met122Leu Single submitter ⚠
- p.Pro118Arg Single submitter ⚠
- p.Ser21Tyr Single submitter ⚠
- p.Ser275Cys Single submitter ⚠
- p.Ser275Phe Single submitter ⚠
- p.Ser298Asn Single submitter ⚠
- p.Ser384Thr Single submitter ⚠
- p.Ser73Cys Single submitter ⚠
- p.Ser77Asn Single submitter ⚠
- p.Thr222Ile Single submitter ⚠
- p.Thr24Asn Single submitter ⚠
- p.Thr287Ala Single submitter ⚠
- p.Thr345Ala Single submitter ⚠
- p.Trp213Leu Single submitter
- p.Tyr353His Single submitter ⚠
- p.Val105Ala Single submitter ⚠
- p.Val125Leu Single submitter ⚠
- p.Val154Ala Single submitter ⚠
- p.Val195Asp Single submitter ⚠