F2RL1 — 48 ClinVar variants
All ClinVar germline F2RL1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 33 flagged for review →
1 Benign · 3 Likely benign · 44 Uncertain significance
Full F2RL1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 33
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 33
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- F2RL1 p.Ala12Val Uncertain significance Single submitter
- F2RL1 p.Ala188Thr Uncertain significance Single submitter
- F2RL1 p.Ala18Ser Uncertain significance Single submitter
- F2RL1 p.Ala220Val Uncertain significance Single submitter
- F2RL1 p.Ala273Thr Uncertain significance Single submitter
- F2RL1 p.Ala358Thr Uncertain significance Single submitter
- F2RL1 p.Arg284Lys Uncertain significance Single submitter
- F2RL1 p.Arg2Gln Uncertain significance Single submitter
- F2RL1 p.Arg365Cys Uncertain significance Single submitter
- F2RL1 p.Asn189Asp Uncertain significance Single submitter
- F2RL1 p.Asp238Glu Uncertain significance Single submitter
- F2RL1 p.Glu56Gly Uncertain significance Single submitter
- F2RL1 p.Gly52Arg Uncertain significance Single submitter
- F2RL1 p.Gly94Ser Uncertain significance Single submitter
- F2RL1 p.Ile126Thr Uncertain significance Single submitter
- F2RL1 p.Ile194Thr Uncertain significance Single submitter
- F2RL1 p.Ile198Val Uncertain significance Single submitter
- F2RL1 p.Ile248Thr Uncertain significance Single submitter
- F2RL1 p.Leu147Val Uncertain significance Single submitter
- F2RL1 p.Leu234Pro Uncertain significance Single submitter
- F2RL1 p.Leu360Phe Uncertain significance Single submitter
- F2RL1 p.Lys107Arg Uncertain significance Single submitter
- F2RL1 p.Met265Leu Uncertain significance Single submitter
- F2RL1 p.Pro254Leu Uncertain significance Single submitter
- F2RL1 p.Ser30Gly Uncertain significance Single submitter
- F2RL1 p.Ser373Phe Uncertain significance Single submitter
- F2RL1 p.Ser389Ile Uncertain significance Single submitter
- F2RL1 p.Ser5Thr Uncertain significance Single submitter
- F2RL1 p.Thr104Ala Uncertain significance Single submitter
- F2RL1 p.Tyr397Cys Uncertain significance Single submitter
- F2RL1 p.Val236Leu Uncertain significance Single submitter
- F2RL1 p.Val236Met Uncertain significance Single submitter
- F2RL1 p.Val87Ala Uncertain significance Single submitter
All F2RL1 variants
Benign 1
- p.Arg2= Multiple submitters
Likely benign 3
- p.Ile80Val Single submitter
- p.Ser363= Single submitter
- p.Ser3Arg Single submitter
Uncertain significance 44
- p.Ala12Val Single submitter ⚠
- p.Ala188Thr Single submitter ⚠
- p.Ala18Ser Single submitter ⚠
- p.Ala220Val Single submitter ⚠
- p.Ala273Thr Single submitter ⚠
- p.Ala358Thr Single submitter ⚠
- p.Arg284Lys Single submitter ⚠
- p.Arg2Gln Single submitter ⚠
- p.Arg365Cys Single submitter ⚠
- p.Asn116Ser Single submitter
- p.Asn189Asp Single submitter ⚠
- p.Asp238Glu Single submitter ⚠
- p.Glu56Gly Single submitter ⚠
- p.Gly52Arg Single submitter ⚠
- p.Gly94Ser Single submitter ⚠
- p.Ile126Thr Single submitter ⚠
- p.Ile194Thr Single submitter ⚠
- p.Ile198Val Single submitter ⚠
- p.Ile248Thr Single submitter ⚠
- p.Leu147Val Single submitter ⚠
- p.Leu234Pro Single submitter ⚠
- p.Leu288Phe Single submitter
- p.Leu305His Single submitter
- p.Leu360Phe Single submitter ⚠
- p.Lys107Arg Single submitter ⚠
- p.Met265Leu Single submitter ⚠
- p.Phe342Leu Single submitter
- p.Pro180Ser Single submitter
- p.Pro231Leu Single submitter
- p.Pro254Leu Single submitter ⚠
- p.Ser30Gly Single submitter ⚠
- p.Ser373Phe Single submitter ⚠
- p.Ser389Ile Single submitter ⚠
- p.Ser5Thr Single submitter ⚠
- p.Ser65Phe Single submitter
- p.Thr104Ala Single submitter ⚠
- p.Thr224Met Single submitter
- p.Trp98Gly Single submitter
- p.Tyr397Cys Single submitter ⚠
- p.Tyr82Cys Single submitter
- p.Val171Met Single submitter
- p.Val236Leu Single submitter ⚠
- p.Val236Met Single submitter ⚠
- p.Val87Ala Single submitter ⚠