F2RL3 — 88 ClinVar variants
All ClinVar germline F2RL3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 70 flagged for review →
4 Benign · 8 Likely benign · 76 Uncertain significance
Full F2RL3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 70
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 61
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- F2RL3 p.Ala128Val Uncertain significance Single submitter
- F2RL3 p.Ala186Gly Uncertain significance Single submitter
- F2RL3 p.Ala199Ser Uncertain significance Single submitter
- F2RL3 p.Ala200Val Uncertain significance Single submitter
- F2RL3 p.Ala208Ser Uncertain significance Single submitter
- F2RL3 p.Ala221Val Uncertain significance Single submitter
- F2RL3 p.Ala231Thr Uncertain significance Single submitter
- F2RL3 p.Ala236Thr Uncertain significance Single submitter
- F2RL3 p.Ala292Thr Uncertain significance Single submitter
- F2RL3 p.Ala314Thr Uncertain significance Single submitter
- F2RL3 p.Ala370Glu Uncertain significance Single submitter
- F2RL3 p.Arg108Gln Uncertain significance Single submitter
- F2RL3 p.Arg108Pro Uncertain significance Single submitter
- F2RL3 p.Arg108Trp Uncertain significance Single submitter
- F2RL3 p.Arg138Cys Uncertain significance Single submitter
- F2RL3 p.Arg141Ser Uncertain significance Single submitter
- F2RL3 p.Arg183Gln Uncertain significance Single submitter
- F2RL3 p.Arg219Gln Uncertain significance Single submitter
- F2RL3 p.Arg222Cys Uncertain significance Single submitter
- F2RL3 p.Arg222Leu Uncertain significance Single submitter
- F2RL3 p.Arg276Gln Uncertain significance Single submitter
- F2RL3 p.Arg352Gln Uncertain significance Single submitter
- F2RL3 p.Arg358Gln Uncertain significance Single submitter
- F2RL3 p.Arg358Trp Uncertain significance Single submitter
- F2RL3 p.Arg68Gln Uncertain significance Single submitter
- F2RL3 p.Arg68Trp Uncertain significance Single submitter
- F2RL3 p.Asn117Ser Uncertain significance Single submitter
- F2RL3 p.Cys247Tyr Uncertain significance Single submitter
- F2RL3 p.Cys54Ser Uncertain significance Single submitter
- F2RL3 p.Cys54Tyr Uncertain significance Single submitter
- F2RL3 p.Gln105Glu Uncertain significance Single submitter
- F2RL3 p.Gly139Ser Uncertain significance Single submitter
- F2RL3 p.Gly275Ser Uncertain significance Single submitter
- F2RL3 p.Gly316Ser Uncertain significance Single submitter
- F2RL3 p.Gly35Ser Uncertain significance Single submitter
- F2RL3 p.Gly373Asp Uncertain significance Single submitter
- F2RL3 p.Gly373Val Uncertain significance Single submitter
- F2RL3 p.His269Tyr Uncertain significance Single submitter
- F2RL3 p.His380Tyr Uncertain significance Single submitter
- F2RL3 p.Leu207Val Uncertain significance Single submitter
- F2RL3 p.Leu326Val Uncertain significance Single submitter
- F2RL3 p.Phe254Ile Uncertain significance Single submitter
- F2RL3 p.Pro243Leu Uncertain significance Single submitter
- F2RL3 p.Pro310Ser Uncertain significance Single submitter
- F2RL3 p.Pro312Ser Uncertain significance Single submitter
- F2RL3 p.Pro360Arg Uncertain significance Single submitter
- F2RL3 p.Pro360Gln Uncertain significance Single submitter
- F2RL3 p.Ser308Leu Uncertain significance Single submitter
- F2RL3 p.Ser31Arg Uncertain significance Single submitter
- F2RL3 p.Ser369Pro Uncertain significance Single submitter
- F2RL3 p.Ser66Asn Uncertain significance Single submitter
- F2RL3 p.Thr153Met Uncertain significance Single submitter
- F2RL3 p.Thr267Ile Uncertain significance Single submitter
- F2RL3 p.Thr39Met Uncertain significance Single submitter
- F2RL3 p.Trp2Arg Uncertain significance Single submitter
- F2RL3 p.Val293Met Uncertain significance Single submitter
- F2RL3 p.Val297Met Uncertain significance Single submitter
- F2RL3 p.Val335Met Uncertain significance Single submitter
- F2RL3 p.Val351Leu Uncertain significance Single submitter
- F2RL3 p.Val53Phe Uncertain significance Single submitter
- F2RL3 p.Val75Met Uncertain significance Single submitter
Predictors split 9
The independent predictors disagree with each other — read with care.
- F2RL3 p.Ala82Asp Uncertain significance Single submitter
- F2RL3 p.Arg191Cys Uncertain significance Single submitter
- F2RL3 p.Arg219Trp Uncertain significance Single submitter
- F2RL3 p.Arg277Cys Uncertain significance Single submitter
- F2RL3 p.Arg283Ser Uncertain significance Single submitter
- F2RL3 p.Pro143Arg Uncertain significance Single submitter
- F2RL3 p.Pro64Leu Uncertain significance Single submitter
- F2RL3 p.Pro93Leu Uncertain significance Single submitter
- F2RL3 p.Ser333Thr Uncertain significance Single submitter
All F2RL3 variants
Benign 4
- p.Ala120Thr Multiple submitters
- p.Leu257= Multiple submitters
- p.Tyr322= Multiple submitters
- p.Ala370= Single submitter
Likely benign 8
- p.Ala206Thr Single submitter
- p.Ala231Val Single submitter
- p.Arg190Gln Single submitter
- p.Gly279Ser Single submitter
- p.Pro181= Single submitter
- p.Thr60Ile Single submitter
- p.Val170Ile Single submitter
- p.Val25Ile Single submitter
Uncertain significance 76
- p.Ala128Val Single submitter ⚠
- p.Ala186Gly Single submitter ⚠
- p.Ala199Ser Single submitter ⚠
- p.Ala200Val Single submitter ⚠
- p.Ala208Ser Single submitter ⚠
- p.Ala221Val Single submitter ⚠
- p.Ala231Thr Single submitter ⚠
- p.Ala236Thr Single submitter ⚠
- p.Ala292Thr Single submitter ⚠
- p.Ala314Thr Single submitter ⚠
- p.Ala370Glu Single submitter ⚠
- p.Ala82Asp Single submitter ⚠
- p.Arg108Gln Single submitter ⚠
- p.Arg108Pro Single submitter ⚠
- p.Arg108Trp Single submitter ⚠
- p.Arg138Cys Single submitter ⚠
- p.Arg141Ser Single submitter ⚠
- p.Arg183Gln Single submitter ⚠
- p.Arg191Cys Single submitter ⚠
- p.Arg219Gln Single submitter ⚠
- p.Arg219Trp Single submitter ⚠
- p.Arg222Cys Single submitter ⚠
- p.Arg222Leu Single submitter ⚠
- p.Arg276Gln Single submitter ⚠
- p.Arg277Cys Single submitter ⚠
- p.Arg283Ser Single submitter ⚠
- p.Arg352Gln Single submitter ⚠
- p.Arg358Gln Single submitter ⚠
- p.Arg358Trp Single submitter ⚠
- p.Arg68Gln Single submitter ⚠
- p.Arg68Trp Single submitter ⚠
- p.Asn117Ser Single submitter ⚠
- p.Cys247Tyr Single submitter ⚠
- p.Cys54Ser Single submitter ⚠
- p.Cys54Tyr Single submitter ⚠
- p.Gln105Glu Single submitter ⚠
- p.Gly139Ser Single submitter ⚠
- p.Gly145Arg Single submitter
- p.Gly275Ser Single submitter ⚠
- p.Gly316Ser Single submitter ⚠
- p.Gly35Ser Single submitter ⚠
- p.Gly373Asp Single submitter ⚠
- p.Gly373Val Single submitter ⚠
- p.His269Tyr Single submitter ⚠
- p.His306Tyr Single submitter
- p.His380Tyr Single submitter ⚠
- p.Leu207Val Single submitter ⚠
- p.Leu220Arg Single submitter
- p.Leu326Val Single submitter ⚠
- p.Phe254Ile Single submitter ⚠
- p.Pro143Arg Single submitter ⚠
- p.Pro233Ser Single submitter
- p.Pro233Thr Single submitter
- p.Pro243Leu Single submitter ⚠
- p.Pro310Ser Single submitter ⚠
- p.Pro312Ser Single submitter ⚠
- p.Pro360Arg Single submitter ⚠
- p.Pro360Gln Single submitter ⚠
- p.Pro64Leu Single submitter ⚠
- p.Pro93Leu Single submitter ⚠
- p.Ser308Leu Single submitter ⚠
- p.Ser31Arg Single submitter ⚠
- p.Ser333Thr Single submitter ⚠
- p.Ser369Pro Single submitter ⚠
- p.Ser66Asn Single submitter ⚠
- p.Thr153Met Single submitter ⚠
- p.Thr267Ile Single submitter ⚠
- p.Thr39Met Single submitter ⚠
- p.Trp2Arg Single submitter ⚠
- p.Val293Met Single submitter ⚠
- p.Val297Met Single submitter ⚠
- p.Val335Gly Single submitter
- p.Val335Met Single submitter ⚠
- p.Val351Leu Single submitter ⚠
- p.Val53Phe Single submitter ⚠
- p.Val75Met Single submitter ⚠