F3 — 48 ClinVar variants
All ClinVar germline F3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 35 flagged for review →
4 Benign · 7 Likely benign · 37 Uncertain significance
Full F3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 35
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 30
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- F3 p.Ala17Thr Uncertain significance Single submitter
- F3 p.Ala30Thr Uncertain significance Single submitter
- F3 p.Arg11His Uncertain significance Single submitter
- F3 p.Arg8Gln Uncertain significance Single submitter
- F3 p.Arg8Trp Uncertain significance Single submitter
- F3 p.Asn169Ser Uncertain significance Single submitter
- F3 p.Glu149Asp Uncertain significance Single submitter
- F3 p.Gly113Glu Uncertain significance Single submitter
- F3 p.Gly119Ser Uncertain significance Single submitter
- F3 p.Gly122Val Uncertain significance Single submitter
- F3 p.Gly180Ser Uncertain significance Single submitter
- F3 p.Gly196Arg Uncertain significance Single submitter
- F3 p.Gly23Val Uncertain significance Single submitter
- F3 p.Ile252Leu Uncertain significance Single submitter
- F3 p.Ile252Thr Uncertain significance Single submitter
- F3 p.Ile264Leu Uncertain significance Single submitter
- F3 p.Ile265Val Uncertain significance Single submitter
- F3 p.Pro111Leu Uncertain significance Single submitter
- F3 p.Pro12Ala Uncertain significance Single submitter
- F3 p.Pro291Ser Uncertain significance Single submitter
- F3 p.Ser174Arg Uncertain significance Single submitter
- F3 p.Thr102Met Uncertain significance Single submitter
- F3 p.Thr158Ser Uncertain significance Single submitter
- F3 p.Thr19Met Uncertain significance Single submitter
- F3 p.Thr204Pro Uncertain significance Single submitter
- F3 p.Thr49Ala Uncertain significance Single submitter
- F3 p.Thr85Ile Uncertain significance Single submitter
- F3 p.Val159Ile Uncertain significance Single submitter
- F3 p.Val25Phe Uncertain significance Single submitter
- F3 p.Val9Ile Uncertain significance Single submitter
Predictors split 5
The independent predictors disagree with each other — read with care.
All F3 variants
Benign 4
- p.Arg163Trp Multiple submitters ⚠
- p.Gly281Glu Multiple submitters
- p.Thr36Ala Multiple submitters
- p.Asp93Gly Single submitter
Likely benign 7
- p.Ala40Thr Single submitter
- p.Arg232Gln Single submitter
- p.Gly122Glu Single submitter
- p.Ile256Val Single submitter
- p.Ile272Val Single submitter
- p.Ile54Val Single submitter
- p.Val62Ile Single submitter
Uncertain significance 37
- p.Ala17Thr Single submitter ⚠
- p.Ala30Thr Single submitter ⚠
- p.Arg11His Single submitter ⚠
- p.Arg176Trp Single submitter
- p.Arg228Gln Single submitter
- p.Arg8Gln Single submitter ⚠
- p.Arg8Trp Single submitter ⚠
- p.Asn114Ile Single submitter ⚠
- p.Asn169Ser Single submitter ⚠
- p.Glu149Asp Single submitter ⚠
- p.Gly113Glu Single submitter ⚠
- p.Gly119Ser Single submitter ⚠
- p.Gly122Val Single submitter ⚠
- p.Gly180Ser Single submitter ⚠
- p.Gly196Arg Single submitter ⚠
- p.Gly23Val Single submitter ⚠
- p.Ile252Leu Single submitter ⚠
- p.Ile252Thr Single submitter ⚠
- p.Ile264Leu Single submitter ⚠
- p.Ile265Val Single submitter ⚠
- p.Phe172Ser Single submitter ⚠
- p.Pro111Leu Single submitter ⚠
- p.Pro12Ala Single submitter ⚠
- p.Pro291Ser Single submitter ⚠
- p.Ser174Arg Single submitter ⚠
- p.Thr102Met Single submitter ⚠
- p.Thr158Ser Single submitter ⚠
- p.Thr19Met Single submitter ⚠
- p.Thr204Ile Single submitter ⚠
- p.Thr204Pro Single submitter ⚠
- p.Thr49Ala Single submitter ⚠
- p.Thr85Ile Single submitter ⚠
- p.Val159Ile Single submitter ⚠
- p.Val211Ala Single submitter ⚠
- p.Val25Phe Single submitter ⚠
- p.Val9Ile Single submitter ⚠
- p.Ser117fs No assertion criteria