FABP1 — 20 ClinVar variants
All ClinVar germline FABP1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 18 flagged for review →
2 Likely benign · 18 Uncertain significance
Full FABP1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 18
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 11
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- FABP1 p.Asn14Tyr Uncertain significance Single submitter
- FABP1 p.Asn44Ser Uncertain significance Single submitter
- FABP1 p.Gly116Asp Uncertain significance Single submitter
- FABP1 p.Gly37Glu Uncertain significance Single submitter
- FABP1 p.Ile108Val Uncertain significance Single submitter
- FABP1 p.Ile35Thr Uncertain significance Single submitter
- FABP1 p.Met19Ile Uncertain significance Single submitter
- FABP1 p.Ser100Thr Uncertain significance Single submitter
- FABP1 p.Ser56Thr Uncertain significance Single submitter
- FABP1 p.Thr75Ile Uncertain significance Single submitter
- FABP1 p.Tyr7Asp Uncertain significance Single submitter
Predictors split 7
The independent predictors disagree with each other — read with care.
- FABP1 p.Asp117Ala Uncertain significance Single submitter
- FABP1 p.Gln8Arg Uncertain significance Single submitter
- FABP1 p.Glu62Ala Uncertain significance Single submitter
- FABP1 p.Gly32Arg Uncertain significance Single submitter
- FABP1 p.Lys125Arg Uncertain significance Single submitter
- FABP1 p.Met19Val Uncertain significance Single submitter
- FABP1 p.Ser4Tyr Uncertain significance Single submitter
All FABP1 variants
Likely benign 2
- p.Asp88Asn Single submitter
- p.Ser4= Single submitter
Uncertain significance 18
- p.Asn14Tyr Single submitter ⚠
- p.Asn44Ser Single submitter ⚠
- p.Asp117Ala Single submitter ⚠
- p.Gln8Arg Single submitter ⚠
- p.Glu62Ala Single submitter ⚠
- p.Gly116Asp Single submitter ⚠
- p.Gly32Arg Single submitter ⚠
- p.Gly37Glu Single submitter ⚠
- p.Ile108Val Single submitter ⚠
- p.Ile35Thr Single submitter ⚠
- p.Lys125Arg Single submitter ⚠
- p.Met19Ile Single submitter ⚠
- p.Met19Val Single submitter ⚠
- p.Ser100Thr Single submitter ⚠
- p.Ser4Tyr Single submitter ⚠
- p.Ser56Thr Single submitter ⚠
- p.Thr75Ile Single submitter ⚠
- p.Tyr7Asp Single submitter ⚠