FABP3 — 24 ClinVar variants
All ClinVar germline FABP3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 19 flagged for review →
1 Benign · 5 Likely benign · 18 Uncertain significance
Full FABP3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 19
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 14
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- FABP3 p.Arg107Trp Uncertain significance Single submitter
- FABP3 p.Arg127His Uncertain significance Single submitter
- FABP3 p.Asn16Asp Uncertain significance Single submitter
- FABP3 p.Asp18Gly Uncertain significance Single submitter
- FABP3 p.Asp77Asn Uncertain significance Single submitter
- FABP3 p.Glu132Ala Uncertain significance Single submitter
- FABP3 p.Ile63Val Uncertain significance Single submitter
- FABP3 p.Lys59Gln Uncertain significance Single submitter
- FABP3 p.Met36Thr Uncertain significance Single submitter
- FABP3 p.Phe65Leu Uncertain significance Single submitter
- FABP3 p.Ser35Thr Uncertain significance Single submitter
- FABP3 p.Thr8Ser Uncertain significance Single submitter
- FABP3 p.Val2Ala Uncertain significance Single submitter
- FABP3 p.Val93Leu Uncertain significance Single submitter
Predictors split 5
The independent predictors disagree with each other — read with care.
All FABP3 variants
Benign 1
- p.Asp99= Multiple submitters
Likely benign 5
- p.Asp3Gly Single submitter ⚠
- p.Asp99Asn Single submitter
- p.His120= Single submitter
- p.Ile84Thr Single submitter
- p.Lys53Ile Single submitter
Uncertain significance 18
- p.Arg107Trp Single submitter ⚠
- p.Arg127His Single submitter ⚠
- p.Asn16Asp Single submitter ⚠
- p.Asp18Gly Single submitter ⚠
- p.Asp77Asn Single submitter ⚠
- p.Glu130Asp Single submitter ⚠
- p.Glu132Ala Single submitter ⚠
- p.Glu44Lys Single submitter ⚠
- p.Ile63Val Single submitter ⚠
- p.Leu6Pro Single submitter ⚠
- p.Lys59Gln Single submitter ⚠
- p.Met36Thr Single submitter ⚠
- p.Phe65Leu Single submitter ⚠
- p.Ser35Thr Single submitter ⚠
- p.Thr8Ser Single submitter ⚠
- p.Val12Glu Single submitter ⚠
- p.Val2Ala Single submitter ⚠
- p.Val93Leu Single submitter ⚠