FABP4 — 12 ClinVar variants
All ClinVar germline FABP4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 8 flagged for review →
2 Benign · 2 Likely benign · 8 Uncertain significance
Full FABP4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 8
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 6
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- FABP4 p.Gly89Glu Uncertain significance Single submitter
- FABP4 p.Leu67Val Uncertain significance Single submitter
- FABP4 p.Phe28Ile Uncertain significance Single submitter
- FABP4 p.Thr104Ile Uncertain significance Single submitter
- FABP4 p.Thr124Ile Uncertain significance Single submitter
- FABP4 p.Val45Leu Uncertain significance Single submitter
Predictors split 2
The independent predictors disagree with each other — read with care.
All FABP4 variants
Likely benign 2
- p.Lys108= Single submitter
- p.Val119Ile Single submitter
Uncertain significance 8
- p.Asp88Ala Single submitter ⚠
- p.Gly89Glu Single submitter ⚠
- p.Leu67Val Single submitter ⚠
- p.Phe28Ile Single submitter ⚠
- p.Thr104Ile Single submitter ⚠
- p.Thr124Ile Single submitter ⚠
- p.Thr51Ile Single submitter ⚠
- p.Val45Leu Single submitter ⚠