FAM110C — 71 ClinVar variants
All ClinVar germline FAM110C variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 70 flagged for review →
71 Uncertain significance
Full FAM110C gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 70
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 63
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- FAM110C p.Ala146Val Uncertain significance Single submitter
- FAM110C p.Ala159Val Uncertain significance Single submitter
- FAM110C p.Ala163Pro Uncertain significance Single submitter
- FAM110C p.Ala175Thr Uncertain significance Single submitter
- FAM110C p.Ala182Val Uncertain significance Single submitter
- FAM110C p.Ala29Val Uncertain significance Single submitter
- FAM110C p.Ala5Thr Uncertain significance Single submitter
- FAM110C p.Ala79Val Uncertain significance Single submitter
- FAM110C p.Ala89Val Uncertain significance Single submitter
- FAM110C p.Ala9Thr Uncertain significance Single submitter
- FAM110C p.Ala9Val Uncertain significance Single submitter
- FAM110C p.Arg111Gln Uncertain significance Single submitter
- FAM110C p.Arg173Gln Uncertain significance Single submitter
- FAM110C p.Arg173Trp Uncertain significance Single submitter
- FAM110C p.Arg18Pro Uncertain significance Single submitter
- FAM110C p.Arg194Cys Uncertain significance Single submitter
- FAM110C p.Arg234Lys Uncertain significance Single submitter
- FAM110C p.Arg24Gly Uncertain significance Single submitter
- FAM110C p.Arg262Trp Uncertain significance Single submitter
- FAM110C p.Arg30Gln Uncertain significance Single submitter
- FAM110C p.Arg33His Uncertain significance Single submitter
- FAM110C p.Arg33Leu Uncertain significance Single submitter
- FAM110C p.Arg34Gly Uncertain significance Single submitter
- FAM110C p.Arg51Trp Uncertain significance Single submitter
- FAM110C p.Arg56Pro Uncertain significance Single submitter
- FAM110C p.Arg80Cys Uncertain significance Single submitter
- FAM110C p.Asn148Ser Uncertain significance Single submitter
- FAM110C p.Asp25His Uncertain significance Single submitter
- FAM110C p.Asp267Gly Uncertain significance Single submitter
- FAM110C p.Asp27Tyr Uncertain significance Single submitter
- FAM110C p.Asp74Tyr Uncertain significance Single submitter
- FAM110C p.Gln201Pro Uncertain significance Single submitter
- FAM110C p.Glu143Lys Uncertain significance Single submitter
- FAM110C p.Gly144Val Uncertain significance Single submitter
- FAM110C p.Gly196Ala Uncertain significance Single submitter
- FAM110C p.Gly259Asp Uncertain significance Single submitter
- FAM110C p.Gly50Ser Uncertain significance Single submitter
- FAM110C p.Gly66Arg Uncertain significance Single submitter
- FAM110C p.Gly76Trp Uncertain significance Single submitter
- FAM110C p.Ile293Val Uncertain significance Single submitter
- FAM110C p.Leu276Arg Uncertain significance Single submitter
- FAM110C p.Leu7Gln Uncertain significance Single submitter
- FAM110C p.Lys134Arg Uncertain significance Single submitter
- FAM110C p.Lys247Gln Uncertain significance Single submitter
- FAM110C p.Phe109Val Uncertain significance Single submitter
- FAM110C p.Pro10Ser Uncertain significance Single submitter
- FAM110C p.Pro138Ser Uncertain significance Single submitter
- FAM110C p.Pro149Leu Uncertain significance Single submitter
- FAM110C p.Pro162His Uncertain significance Single submitter
- FAM110C p.Pro177Thr Uncertain significance Single submitter
- FAM110C p.Pro181Leu Uncertain significance Single submitter
- FAM110C p.Pro184Thr Uncertain significance Single submitter
- FAM110C p.Pro189Thr Uncertain significance Single submitter
- FAM110C p.Pro226Arg Uncertain significance Single submitter
- FAM110C p.Pro52Leu Uncertain significance Single submitter
- FAM110C p.Pro65Leu Uncertain significance Single submitter
- FAM110C p.Pro71Ser Uncertain significance Single submitter
- FAM110C p.Pro82Arg Uncertain significance Single submitter
- FAM110C p.Ser174Pro Uncertain significance Single submitter
- FAM110C p.Ser241Leu Uncertain significance Single submitter
- FAM110C p.Ser63Gly Uncertain significance Single submitter
- FAM110C p.Thr238Ile Uncertain significance Single submitter
- FAM110C p.Thr255Asn Uncertain significance Single submitter
Predictors split 7
The independent predictors disagree with each other — read with care.
- FAM110C p.Ala36Ser Uncertain significance Single submitter
- FAM110C p.Arg44Cys Uncertain significance Single submitter
- FAM110C p.Arg49Trp Uncertain significance Single submitter
- FAM110C p.Arg87Ser Uncertain significance Single submitter
- FAM110C p.Asn290Lys Uncertain significance Single submitter
- FAM110C p.Phe127Leu Uncertain significance Single submitter
- FAM110C p.Tyr103His Uncertain significance Single submitter
All FAM110C variants
Uncertain significance 71
- p.Ala146Val Single submitter ⚠
- p.Ala159Val Single submitter ⚠
- p.Ala163Pro Single submitter ⚠
- p.Ala175Thr Single submitter ⚠
- p.Ala182Val Single submitter ⚠
- p.Ala29Val Single submitter ⚠
- p.Ala36Ser Single submitter ⚠
- p.Ala5Thr Single submitter ⚠
- p.Ala79Val Single submitter ⚠
- p.Ala89Val Single submitter ⚠
- p.Ala9Thr Single submitter ⚠
- p.Ala9Val Single submitter ⚠
- p.Arg111Gln Single submitter ⚠
- p.Arg173Gln Single submitter ⚠
- p.Arg173Trp Single submitter ⚠
- p.Arg18Pro Single submitter ⚠
- p.Arg194Cys Single submitter ⚠
- p.Arg234Lys Single submitter ⚠
- p.Arg24Gly Single submitter ⚠
- p.Arg262Trp Single submitter ⚠
- p.Arg30Gln Single submitter ⚠
- p.Arg33His Single submitter ⚠
- p.Arg33Leu Single submitter ⚠
- p.Arg34Gly Single submitter ⚠
- p.Arg44Cys Single submitter ⚠
- p.Arg49Trp Single submitter ⚠
- p.Arg51Trp Single submitter ⚠
- p.Arg56Pro Single submitter ⚠
- p.Arg80Cys Single submitter ⚠
- p.Arg87Ser Single submitter ⚠
- p.Asn148Ser Single submitter ⚠
- p.Asn290Lys Single submitter ⚠
- p.Asp225Tyr Single submitter
- p.Asp25His Single submitter ⚠
- p.Asp267Gly Single submitter ⚠
- p.Asp27Tyr Single submitter ⚠
- p.Asp74Tyr Single submitter ⚠
- p.Gln201Pro Single submitter ⚠
- p.Glu143Lys Single submitter ⚠
- p.Gly144Val Single submitter ⚠
- p.Gly196Ala Single submitter ⚠
- p.Gly259Asp Single submitter ⚠
- p.Gly50Ser Single submitter ⚠
- p.Gly66Arg Single submitter ⚠
- p.Gly76Trp Single submitter ⚠
- p.Ile293Val Single submitter ⚠
- p.Leu276Arg Single submitter ⚠
- p.Leu7Gln Single submitter ⚠
- p.Lys134Arg Single submitter ⚠
- p.Lys247Gln Single submitter ⚠
- p.Phe109Val Single submitter ⚠
- p.Phe127Leu Single submitter ⚠
- p.Pro10Ser Single submitter ⚠
- p.Pro138Ser Single submitter ⚠
- p.Pro149Leu Single submitter ⚠
- p.Pro162His Single submitter ⚠
- p.Pro177Thr Single submitter ⚠
- p.Pro181Leu Single submitter ⚠
- p.Pro184Thr Single submitter ⚠
- p.Pro189Thr Single submitter ⚠
- p.Pro226Arg Single submitter ⚠
- p.Pro52Leu Single submitter ⚠
- p.Pro65Leu Single submitter ⚠
- p.Pro71Ser Single submitter ⚠
- p.Pro82Arg Single submitter ⚠
- p.Ser174Pro Single submitter ⚠
- p.Ser241Leu Single submitter ⚠
- p.Ser63Gly Single submitter ⚠
- p.Thr238Ile Single submitter ⚠
- p.Thr255Asn Single submitter ⚠
- p.Tyr103His Single submitter ⚠