FAM162A — 20 ClinVar variants

All ClinVar germline FAM162A variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 14 flagged for review →

2 Likely benign · 18 Uncertain significance

Full FAM162A gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 14

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors lean, ClinVar uncertain 9

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 5

The independent predictors disagree with each other — read with care.

All FAM162A variants

Likely benign 2

p.Gly49Arg Single submitter
p.Leu106Val Single submitter

Uncertain significance 18

p.Ala126Thr Single submitter ⚠
p.Ala141Val Single submitter ⚠
p.Arg100Gln Single submitter
p.Arg142His Single submitter ⚠
p.Arg142Pro Single submitter ⚠
p.Arg76Cys Single submitter ⚠
p.Cys41Phe Single submitter
p.Glu130Lys Single submitter ⚠
p.Ile120Thr Single submitter ⚠
p.Leu4Arg Single submitter ⚠
p.Lys123Arg Single submitter ⚠
p.Lys124Gln Single submitter ⚠
p.Lys152Arg Single submitter ⚠
p.Lys78Arg Single submitter ⚠
p.Lys78Glu Single submitter
p.Lys96Asn Single submitter ⚠
p.Pro63Leu Single submitter
p.Trp66Cys Single submitter ⚠