FAM83A — 70 ClinVar variants
All ClinVar germline FAM83A variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 62 flagged for review →
4 Likely benign · 66 Uncertain significance
Full FAM83A gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 62
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 52
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- FAM83A p.Ala291Val Uncertain significance Single submitter
- FAM83A p.Ala88Val Uncertain significance Single submitter
- FAM83A p.Arg185Cys Uncertain significance Single submitter
- FAM83A p.Arg23Gln Uncertain significance Single submitter
- FAM83A p.Arg23Gly Uncertain significance Single submitter
- FAM83A p.Arg241Trp Uncertain significance Single submitter
- FAM83A p.Arg368Leu Uncertain significance Single submitter
- FAM83A p.Arg36Gln Uncertain significance Single submitter
- FAM83A p.Arg3Trp Uncertain significance Single submitter
- FAM83A p.Arg408Gln Uncertain significance Single submitter
- FAM83A p.Asn32His Uncertain significance Single submitter
- FAM83A p.Asn400Tyr Uncertain significance Single submitter
- FAM83A p.Asp28Glu Uncertain significance Single submitter
- FAM83A p.Asp83Asn Uncertain significance Single submitter
- FAM83A p.Gln56His Uncertain significance Single submitter
- FAM83A p.Glu173Lys Uncertain significance Single submitter
- FAM83A p.Glu180Gln Uncertain significance Single submitter
- FAM83A p.Glu284Gln Uncertain significance Single submitter
- FAM83A p.Gly103Asp Uncertain significance Single submitter
- FAM83A p.Gly103Ser Uncertain significance Single submitter
- FAM83A p.Gly298Val Uncertain significance Single submitter
- FAM83A p.Gly337Cys Uncertain significance Single submitter
- FAM83A p.Gly345Ser Uncertain significance Single submitter
- FAM83A p.Gly374Asp Uncertain significance Single submitter
- FAM83A p.His265Arg Uncertain significance Single submitter
- FAM83A p.His372Gln Uncertain significance Single submitter
- FAM83A p.Ile164Val Uncertain significance Single submitter
- FAM83A p.Ile174Val Uncertain significance Single submitter
- FAM83A p.Ile218Val Uncertain significance Single submitter
- FAM83A p.Ile71Thr Uncertain significance Single submitter
- FAM83A p.Leu118Gln Uncertain significance Single submitter
- FAM83A p.Leu14Val Uncertain significance Single submitter
- FAM83A p.Leu414Met Uncertain significance Single submitter
- FAM83A p.Leu42Phe Uncertain significance Single submitter
- FAM83A p.Lys93Thr Uncertain significance Single submitter
- FAM83A p.Phe201Ser Uncertain significance Single submitter
- FAM83A p.Pro334Ser Uncertain significance Single submitter
- FAM83A p.Pro361Leu Uncertain significance Single submitter
- FAM83A p.Pro366Gln Uncertain significance Single submitter
- FAM83A p.Pro366Leu Uncertain significance Single submitter
- FAM83A p.Pro367Ala Uncertain significance Single submitter
- FAM83A p.Pro406Thr Uncertain significance Single submitter
- FAM83A p.Ser113Arg Uncertain significance Single submitter
- FAM83A p.Ser327Asn Uncertain significance Single submitter
- FAM83A p.Ser97Phe Uncertain significance Single submitter
- FAM83A p.Ser98Arg Uncertain significance Single submitter
- FAM83A p.Thr170Ser Uncertain significance Single submitter
- FAM83A p.Thr346Ala Uncertain significance Single submitter
- FAM83A p.Thr407Met Uncertain significance Single submitter
- FAM83A p.Val161Ile Uncertain significance Single submitter
- FAM83A p.Val252Ala Uncertain significance Single submitter
- FAM83A p.Val252Gly Uncertain significance Single submitter
Predictors split 10
The independent predictors disagree with each other — read with care.
- FAM83A p.Ala41Thr Uncertain significance Single submitter
- FAM83A p.Arg52Trp Uncertain significance Single submitter
- FAM83A p.Gly197Asp Uncertain significance Single submitter
- FAM83A p.Gly264Arg Uncertain significance Single submitter
- FAM83A p.Gly8Arg Uncertain significance Single submitter
- FAM83A p.Ile10Asn Uncertain significance Single submitter
- FAM83A p.Lys184Asn Uncertain significance Single submitter
- FAM83A p.Phe106Leu Uncertain significance Single submitter
- FAM83A p.Thr275Ile Uncertain significance Single submitter
- FAM83A p.Tyr290Cys Uncertain significance Single submitter
All FAM83A variants
Likely benign 4
- p.Ala90Thr Single submitter
- p.Gly311Arg Single submitter
- p.Gly345Arg Single submitter
- p.Pro81Ala Single submitter
Uncertain significance 66
- p.Ala291Val Single submitter ⚠
- p.Ala41Thr Single submitter ⚠
- p.Ala88Val Single submitter ⚠
- p.Arg13His Single submitter
- p.Arg185Cys Single submitter ⚠
- p.Arg23Gln Single submitter ⚠
- p.Arg23Gly Single submitter ⚠
- p.Arg241Trp Single submitter ⚠
- p.Arg368Leu Single submitter ⚠
- p.Arg36Gln Single submitter ⚠
- p.Arg3Trp Single submitter ⚠
- p.Arg408Gln Single submitter ⚠
- p.Arg52Trp Single submitter ⚠
- p.Asn32His Single submitter ⚠
- p.Asn400Tyr Single submitter ⚠
- p.Asp28Glu Single submitter ⚠
- p.Asp83Asn Single submitter ⚠
- p.Gln56His Single submitter ⚠
- p.Glu173Lys Single submitter ⚠
- p.Glu180Gln Single submitter ⚠
- p.Glu284Gln Single submitter ⚠
- p.Gly103Asp Single submitter ⚠
- p.Gly103Ser Single submitter ⚠
- p.Gly197Asp Single submitter ⚠
- p.Gly264Arg Single submitter ⚠
- p.Gly298Val Single submitter ⚠
- p.Gly337Cys Single submitter ⚠
- p.Gly345Ser Single submitter ⚠
- p.Gly374Asp Single submitter ⚠
- p.Gly8Arg Single submitter ⚠
- p.His265Arg Single submitter ⚠
- p.His372Gln Single submitter ⚠
- p.Ile10Asn Single submitter ⚠
- p.Ile164Val Single submitter ⚠
- p.Ile174Val Single submitter ⚠
- p.Ile218Val Single submitter ⚠
- p.Ile71Thr Single submitter ⚠
- p.Leu118Gln Single submitter ⚠
- p.Leu14Val Single submitter ⚠
- p.Leu289Phe Single submitter
- p.Leu414Met Single submitter ⚠
- p.Leu42Phe Single submitter ⚠
- p.Lys184Asn Single submitter ⚠
- p.Lys93Thr Single submitter ⚠
- p.Phe106Leu Single submitter ⚠
- p.Phe201Ser Single submitter ⚠
- p.Pro334Ser Single submitter ⚠
- p.Pro361Leu Single submitter ⚠
- p.Pro366Gln Single submitter ⚠
- p.Pro366Leu Single submitter ⚠
- p.Pro367Ala Single submitter ⚠
- p.Pro406Thr Single submitter ⚠
- p.Ser113Arg Single submitter ⚠
- p.Ser222Asn Single submitter
- p.Ser327Asn Single submitter ⚠
- p.Ser97Phe Single submitter ⚠
- p.Ser98Arg Single submitter ⚠
- p.Thr170Ser Single submitter ⚠
- p.Thr275Ile Single submitter ⚠
- p.Thr346Ala Single submitter ⚠
- p.Thr407Met Single submitter ⚠
- p.Tyr290Cys Single submitter ⚠
- p.Tyr70Cys Single submitter
- p.Val161Ile Single submitter ⚠
- p.Val252Ala Single submitter ⚠
- p.Val252Gly Single submitter ⚠