FAM83E — 108 ClinVar variants
All ClinVar germline FAM83E variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 102 flagged for review →
6 Likely benign · 102 Uncertain significance
Full FAM83E gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 102
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 85
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- FAM83E p.Ala337Thr Uncertain significance Single submitter
- FAM83E p.Ala338Pro Uncertain significance Single submitter
- FAM83E p.Ala360Thr Uncertain significance Single submitter
- FAM83E p.Ala436Thr Uncertain significance Single submitter
- FAM83E p.Ala43Val Uncertain significance Single submitter
- FAM83E p.Ala68Gly Uncertain significance Single submitter
- FAM83E p.Ala7Val Uncertain significance Single submitter
- FAM83E p.Ala8Val Uncertain significance Single submitter
- FAM83E p.Ala95Thr Uncertain significance Single submitter
- FAM83E p.Arg113Gln Uncertain significance Single submitter
- FAM83E p.Arg113Trp Uncertain significance Single submitter
- FAM83E p.Arg179His Uncertain significance Single submitter
- FAM83E p.Arg219Trp Uncertain significance Single submitter
- FAM83E p.Arg228Gln Uncertain significance Single submitter
- FAM83E p.Arg229Gln Uncertain significance Single submitter
- FAM83E p.Arg282Gln Uncertain significance Single submitter
- FAM83E p.Arg313Cys Uncertain significance Single submitter
- FAM83E p.Arg313His Uncertain significance Single submitter
- FAM83E p.Arg317Cys Uncertain significance Single submitter
- FAM83E p.Arg317His Uncertain significance Single submitter
- FAM83E p.Arg335Cys Uncertain significance Single submitter
- FAM83E p.Arg369Leu Uncertain significance Single submitter
- FAM83E p.Arg372Cys Uncertain significance Single submitter
- FAM83E p.Arg372His Uncertain significance Single submitter
- FAM83E p.Arg411Gln Uncertain significance Single submitter
- FAM83E p.Arg411Trp Uncertain significance Single submitter
- FAM83E p.Arg424Gly Uncertain significance Single submitter
- FAM83E p.Arg438His Uncertain significance Single submitter
- FAM83E p.Arg440Cys Uncertain significance Single submitter
- FAM83E p.Arg440Leu Uncertain significance Single submitter
- FAM83E p.Arg446Pro Uncertain significance Single submitter
- FAM83E p.Arg448Trp Uncertain significance Single submitter
- FAM83E p.Arg52His Uncertain significance Single submitter
- FAM83E p.Asp175Gly Uncertain significance Single submitter
- FAM83E p.Asp62Glu Uncertain significance Single submitter
- FAM83E p.Asp62Gly Uncertain significance Single submitter
- FAM83E p.Asp92Asn Uncertain significance Single submitter
- FAM83E p.Gln129Lys Uncertain significance Single submitter
- FAM83E p.Gln297Glu Uncertain significance Single submitter
- FAM83E p.Gln297Lys Uncertain significance Single submitter
- FAM83E p.Glu245Lys Uncertain significance Single submitter
- FAM83E p.Glu29Lys Uncertain significance Single submitter
- FAM83E p.Gly20Trp Uncertain significance Single submitter
- FAM83E p.Gly244Arg Uncertain significance Single submitter
- FAM83E p.Gly365Ser Uncertain significance Single submitter
- FAM83E p.Gly389Ala Uncertain significance Single submitter
- FAM83E p.Gly475Glu Uncertain significance Single submitter
- FAM83E p.Gly475Val Uncertain significance Single submitter
- FAM83E p.Ile150Val Uncertain significance Single submitter
- FAM83E p.Leu130Arg Uncertain significance Single submitter
- FAM83E p.Leu203Gln Uncertain significance Single submitter
- FAM83E p.Lys155Arg Uncertain significance Single submitter
- FAM83E p.Lys400Arg Uncertain significance Single submitter
- FAM83E p.Pro134Leu Uncertain significance Single submitter
- FAM83E p.Pro140Leu Uncertain significance Single submitter
- FAM83E p.Pro194Arg Uncertain significance Single submitter
- FAM83E p.Pro290Leu Uncertain significance Single submitter
- FAM83E p.Pro296Leu Uncertain significance Single submitter
- FAM83E p.Pro325Leu Uncertain significance Single submitter
- FAM83E p.Pro326Leu Uncertain significance Single submitter
- FAM83E p.Pro328Arg Uncertain significance Single submitter
- FAM83E p.Pro331Arg Uncertain significance Single submitter
- FAM83E p.Pro348Arg Uncertain significance Single submitter
- FAM83E p.Pro403Thr Uncertain significance Single submitter
- FAM83E p.Pro425Ser Uncertain significance Single submitter
- FAM83E p.Pro432Thr Uncertain significance Single submitter
- FAM83E p.Pro470Ser Uncertain significance Single submitter
- FAM83E p.Pro81Ser Uncertain significance Single submitter
- FAM83E p.Ser14Phe Uncertain significance Single submitter
- FAM83E p.Ser324Leu Uncertain significance Single submitter
- FAM83E p.Ser351Asn Uncertain significance Single submitter
- FAM83E p.Ser364Arg Uncertain significance Single submitter
- FAM83E p.Ser378Gly Uncertain significance Single submitter
- FAM83E p.Ser396Tyr Uncertain significance Single submitter
- FAM83E p.Ser423Tyr Uncertain significance Single submitter
- FAM83E p.Ser60Gly Uncertain significance Single submitter
- FAM83E p.Thr126Ile Uncertain significance Single submitter
- FAM83E p.Thr178Lys Uncertain significance Single submitter
- FAM83E p.Thr210Met Uncertain significance Single submitter
- FAM83E p.Thr234Ala Uncertain significance Single submitter
- FAM83E p.Thr89Ile Uncertain significance Single submitter
- FAM83E p.Val111Leu Uncertain significance Single submitter
- FAM83E p.Val215Ala Uncertain significance Single submitter
- FAM83E p.Val314Met Uncertain significance Single submitter
- FAM83E p.Val50Met Uncertain significance Single submitter
Predictors split 17
The independent predictors disagree with each other — read with care.
- FAM83E p.Ala259Val Uncertain significance Single submitter
- FAM83E p.Ala45Val Uncertain significance Single submitter
- FAM83E p.Arg127Gln Uncertain significance Single submitter
- FAM83E p.Arg127Trp Uncertain significance Single submitter
- FAM83E p.Arg147Trp Uncertain significance Single submitter
- FAM83E p.Arg180Cys Uncertain significance Single submitter
- FAM83E p.Arg226Cys Uncertain significance Single submitter
- FAM83E p.Arg229Trp Uncertain significance Single submitter
- FAM83E p.Arg52Cys Uncertain significance Single submitter
- FAM83E p.Asp258Gly Uncertain significance Single submitter
- FAM83E p.Glu72Gly Uncertain significance Single submitter
- FAM83E p.Ile248Thr Uncertain significance Single submitter
- FAM83E p.Pro183Arg Uncertain significance Single submitter
- FAM83E p.Pro295Leu Uncertain significance Single submitter
- FAM83E p.Pro295Ser Uncertain significance Single submitter
- FAM83E p.Thr270Asn Uncertain significance Single submitter
- FAM83E p.Trp74Arg Uncertain significance Single submitter
All FAM83E variants
Likely benign 6
- p.Arg316His Single submitter
- p.Arg318Cys Single submitter
- p.Gly83Arg Single submitter
- p.Pro141Ser Single submitter
- p.Val111Ile Single submitter
- p.Val213Met Single submitter
Uncertain significance 102
- p.Ala259Val Single submitter ⚠
- p.Ala337Thr Single submitter ⚠
- p.Ala338Pro Single submitter ⚠
- p.Ala360Thr Single submitter ⚠
- p.Ala436Thr Single submitter ⚠
- p.Ala43Val Single submitter ⚠
- p.Ala45Val Single submitter ⚠
- p.Ala68Gly Single submitter ⚠
- p.Ala7Val Single submitter ⚠
- p.Ala8Val Single submitter ⚠
- p.Ala95Thr Single submitter ⚠
- p.Arg113Gln Single submitter ⚠
- p.Arg113Trp Single submitter ⚠
- p.Arg127Gln Single submitter ⚠
- p.Arg127Trp Single submitter ⚠
- p.Arg147Trp Single submitter ⚠
- p.Arg179His Single submitter ⚠
- p.Arg180Cys Single submitter ⚠
- p.Arg219Trp Single submitter ⚠
- p.Arg226Cys Single submitter ⚠
- p.Arg228Gln Single submitter ⚠
- p.Arg229Gln Single submitter ⚠
- p.Arg229Trp Single submitter ⚠
- p.Arg282Gln Single submitter ⚠
- p.Arg313Cys Single submitter ⚠
- p.Arg313His Single submitter ⚠
- p.Arg317Cys Single submitter ⚠
- p.Arg317His Single submitter ⚠
- p.Arg335Cys Single submitter ⚠
- p.Arg369Leu Single submitter ⚠
- p.Arg372Cys Single submitter ⚠
- p.Arg372His Single submitter ⚠
- p.Arg411Gln Single submitter ⚠
- p.Arg411Trp Single submitter ⚠
- p.Arg424Gly Single submitter ⚠
- p.Arg438His Single submitter ⚠
- p.Arg440Cys Single submitter ⚠
- p.Arg440Leu Single submitter ⚠
- p.Arg446Pro Single submitter ⚠
- p.Arg448Trp Single submitter ⚠
- p.Arg52Cys Single submitter ⚠
- p.Arg52His Single submitter ⚠
- p.Asp175Gly Single submitter ⚠
- p.Asp258Gly Single submitter ⚠
- p.Asp62Glu Single submitter ⚠
- p.Asp62Gly Single submitter ⚠
- p.Asp92Asn Single submitter ⚠
- p.Gln129Lys Single submitter ⚠
- p.Gln297Glu Single submitter ⚠
- p.Gln297Lys Single submitter ⚠
- p.Glu245Lys Single submitter ⚠
- p.Glu29Lys Single submitter ⚠
- p.Glu72Gly Single submitter ⚠
- p.Gly20Trp Single submitter ⚠
- p.Gly244Arg Single submitter ⚠
- p.Gly365Ser Single submitter ⚠
- p.Gly389Ala Single submitter ⚠
- p.Gly475Glu Single submitter ⚠
- p.Gly475Val Single submitter ⚠
- p.Ile150Val Single submitter ⚠
- p.Ile248Thr Single submitter ⚠
- p.Leu130Arg Single submitter ⚠
- p.Leu203Gln Single submitter ⚠
- p.Lys155Arg Single submitter ⚠
- p.Lys400Arg Single submitter ⚠
- p.Pro134Leu Single submitter ⚠
- p.Pro140Leu Single submitter ⚠
- p.Pro183Arg Single submitter ⚠
- p.Pro194Arg Single submitter ⚠
- p.Pro290Leu Single submitter ⚠
- p.Pro295Leu Single submitter ⚠
- p.Pro295Ser Single submitter ⚠
- p.Pro296Leu Single submitter ⚠
- p.Pro325Leu Single submitter ⚠
- p.Pro326Leu Single submitter ⚠
- p.Pro328Arg Single submitter ⚠
- p.Pro331Arg Single submitter ⚠
- p.Pro348Arg Single submitter ⚠
- p.Pro403Thr Single submitter ⚠
- p.Pro425Ser Single submitter ⚠
- p.Pro432Thr Single submitter ⚠
- p.Pro470Ser Single submitter ⚠
- p.Pro81Ser Single submitter ⚠
- p.Ser14Phe Single submitter ⚠
- p.Ser324Leu Single submitter ⚠
- p.Ser351Asn Single submitter ⚠
- p.Ser364Arg Single submitter ⚠
- p.Ser378Gly Single submitter ⚠
- p.Ser396Tyr Single submitter ⚠
- p.Ser423Tyr Single submitter ⚠
- p.Ser60Gly Single submitter ⚠
- p.Thr126Ile Single submitter ⚠
- p.Thr178Lys Single submitter ⚠
- p.Thr210Met Single submitter ⚠
- p.Thr234Ala Single submitter ⚠
- p.Thr270Asn Single submitter ⚠
- p.Thr89Ile Single submitter ⚠
- p.Trp74Arg Single submitter ⚠
- p.Val111Leu Single submitter ⚠
- p.Val215Ala Single submitter ⚠
- p.Val314Met Single submitter ⚠
- p.Val50Met Single submitter ⚠