FAP — 107 ClinVar variants
All ClinVar germline FAP variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 96 flagged for review →
9 Benign · 6 Likely benign · 92 Uncertain significance
Full FAP gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 96
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 51
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- FAP p.Ala12Val Uncertain significance Single submitter
- FAP p.Ala235Val Uncertain significance Single submitter
- FAP p.Ala273Val Uncertain significance Single submitter
- FAP p.Ala562Val Uncertain significance Single submitter
- FAP p.Ala633Asp Uncertain significance Single submitter
- FAP p.Ala633Val Uncertain significance Single submitter
- FAP p.Arg27Gly Uncertain significance Single submitter
- FAP p.Arg27His Uncertain significance Single submitter
- FAP p.Arg27Pro Uncertain significance Single submitter
- FAP p.Arg422Gly Uncertain significance Single submitter
- FAP p.Asn137Thr Uncertain significance Single submitter
- FAP p.Asn33Lys Uncertain significance Single submitter
- FAP p.Asp108Val Uncertain significance Single submitter
- FAP p.Asp301Asn Uncertain significance Single submitter
- FAP p.Asp457Asn Uncertain significance Single submitter
- FAP p.Asp582Gly Uncertain significance Single submitter
- FAP p.Asp702Val Uncertain significance Single submitter
- FAP p.Gln65Arg Uncertain significance Single submitter
- FAP p.Glu340Lys Uncertain significance Single submitter
- FAP p.Gly348Ser Uncertain significance Single submitter
- FAP p.Gly420Glu Uncertain significance Single submitter
- FAP p.Gly699Arg Uncertain significance Single submitter
- FAP p.Gly735Ser Uncertain significance Single submitter
- FAP p.Ile170Ser Uncertain significance Single submitter
- FAP p.Ile231Thr Uncertain significance Single submitter
- FAP p.Ile231Val Uncertain significance Single submitter
- FAP p.Ile248Val Uncertain significance Single submitter
- FAP p.Ile266Val Uncertain significance Single submitter
- FAP p.Ile398Val Uncertain significance Single submitter
- FAP p.Ile400Val Uncertain significance Single submitter
- FAP p.Ile613Val Uncertain significance Single submitter
- FAP p.Leu494Ser Uncertain significance Single submitter
- FAP p.Leu752Pro Uncertain significance Single submitter
- FAP p.Leu90Trp Uncertain significance Single submitter
- FAP p.Lys209Arg Uncertain significance Single submitter
- FAP p.Met205Ile Uncertain significance Single submitter
- FAP p.Met285Val Uncertain significance Single submitter
- FAP p.Met683Ile Uncertain significance Single submitter
- FAP p.Pro649Ser Uncertain significance Single submitter
- FAP p.Ser14Cys Uncertain significance Single submitter
- FAP p.Ser160Asn Uncertain significance Single submitter
- FAP p.Ser454Thr Uncertain significance Single submitter
- FAP p.Ser551Pro Uncertain significance Single submitter
- FAP p.Thr300Ile Uncertain significance Single submitter
- FAP p.Trp308Arg Uncertain significance Single submitter
- FAP p.Trp653Gly Uncertain significance Single submitter
- FAP p.Tyr210Cys Uncertain significance Single submitter
- FAP p.Tyr418Asn Uncertain significance Single submitter
- FAP p.Tyr625Cys Uncertain significance Single submitter
- FAP p.Val597Phe Uncertain significance Single submitter
- FAP p.Val629Ile Uncertain significance Single submitter
Predictors split 45
The independent predictors disagree with each other — read with care.
- FAP p.Leu212Phe Benign Multiple submitters
- FAP p.Phe185Leu Likely benign Multiple submitters
- FAP p.Thr229Met Benign Multiple submitters
- FAP p.Ala211Val Uncertain significance Single submitter
- FAP p.Ala453Thr Uncertain significance Single submitter
- FAP p.Ala578Val Uncertain significance Single submitter
- FAP p.Ala716Ser Uncertain significance Single submitter
- FAP p.Arg109Gly Uncertain significance Single submitter
- FAP p.Arg263Trp Uncertain significance Single submitter
- FAP p.Arg426Gly Uncertain significance Single submitter
- FAP p.Asp241Asn Uncertain significance Single submitter
- FAP p.Asp370Asn Uncertain significance Single submitter
- FAP p.Asp529Glu Uncertain significance Single submitter
- FAP p.Glu495Lys Uncertain significance Single submitter
- FAP p.Gly430Val Uncertain significance Single submitter
- FAP p.Gly611Asp Uncertain significance Single submitter
- FAP p.Gly639Asp Uncertain significance Single submitter
- FAP p.Gly639Ser Uncertain significance Single submitter
- FAP p.His378Arg Uncertain significance Single submitter
- FAP p.Ile339Met Uncertain significance Single submitter
- FAP p.Ile487Asn Uncertain significance Single submitter
- FAP p.Ile508Thr Uncertain significance Single submitter
- FAP p.Ile608Met Uncertain significance Single submitter
- FAP p.Leu488Met Uncertain significance Single submitter
- FAP p.Leu561Val Uncertain significance Single submitter
- FAP p.Lys371Glu Uncertain significance Single submitter
- FAP p.Lys436Glu Uncertain significance Single submitter
- FAP p.Met567Thr Uncertain significance Single submitter
- FAP p.Phe664Leu Uncertain significance Single submitter
- FAP p.Pro147Leu Uncertain significance Single submitter
- FAP p.Pro147Thr Uncertain significance Single submitter
- FAP p.Pro216Leu Uncertain significance Single submitter
- FAP p.Pro419Ser Uncertain significance Single submitter
- FAP p.Ser116Arg Uncertain significance Single submitter
- FAP p.Ser428Ile Uncertain significance Single submitter
- FAP p.Thr127Ile Uncertain significance Single submitter
- FAP p.Thr3Ile Uncertain significance Single submitter
- FAP p.Thr51Pro Uncertain significance Single submitter
- FAP p.Thr669Ala Uncertain significance Single submitter
- FAP p.Thr88Asn Uncertain significance Single submitter
- FAP p.Tyr745Phe Uncertain significance Single submitter
- FAP p.Val112Ala Likely benign Single submitter
- FAP p.Val549Ile Uncertain significance Single submitter
- FAP p.Val588Met Uncertain significance Single submitter
- FAP p.Val597Ile Uncertain significance Single submitter
All FAP variants
Benign 9
- c.1870-8C>A Multiple submitters
- p.Ala100= Multiple submitters
- p.Gln708= Multiple submitters
- p.Gly195= Multiple submitters
- p.Leu212Phe Multiple submitters ⚠
- p.Thr229Met Multiple submitters ⚠
- p.Tyr458= Multiple submitters
- c.1550-9T>C Single submitter
- c.92-6C>A Single submitter
Likely benign 6
- p.Phe185Leu Multiple submitters ⚠
- p.Ser737= Multiple submitters
- p.Asn37Ser Single submitter
- p.Leu408= Single submitter
- p.Val112Ala Single submitter ⚠
- p.Val304Ile Single submitter
Uncertain significance 92
- p.Ala12Val Single submitter ⚠
- p.Ala211Val Single submitter ⚠
- p.Ala235Val Single submitter ⚠
- p.Ala273Val Single submitter ⚠
- p.Ala453Thr Single submitter ⚠
- p.Ala562Val Single submitter ⚠
- p.Ala578Val Single submitter ⚠
- p.Ala633Asp Single submitter ⚠
- p.Ala633Val Single submitter ⚠
- p.Ala716Ser Single submitter ⚠
- p.Arg109Gly Single submitter ⚠
- p.Arg263Trp Single submitter ⚠
- p.Arg27Gly Single submitter ⚠
- p.Arg27His Single submitter ⚠
- p.Arg27Pro Single submitter ⚠
- p.Arg422Gly Single submitter ⚠
- p.Arg426Gly Single submitter ⚠
- p.Asn137Thr Single submitter ⚠
- p.Asn33Lys Single submitter ⚠
- p.Asp108Val Single submitter ⚠
- p.Asp241Asn Single submitter ⚠
- p.Asp301Asn Single submitter ⚠
- p.Asp370Asn Single submitter ⚠
- p.Asp457Asn Single submitter ⚠
- p.Asp529Glu Single submitter ⚠
- p.Asp582Gly Single submitter ⚠
- p.Asp702Val Single submitter ⚠
- p.Gln65Arg Single submitter ⚠
- p.Glu340Lys Single submitter ⚠
- p.Glu495Lys Single submitter ⚠
- p.Gly348Ser Single submitter ⚠
- p.Gly420Glu Single submitter ⚠
- p.Gly430Val Single submitter ⚠
- p.Gly611Asp Single submitter ⚠
- p.Gly639Asp Single submitter ⚠
- p.Gly639Ser Single submitter ⚠
- p.Gly699Arg Single submitter ⚠
- p.Gly735Ser Single submitter ⚠
- p.His378Arg Single submitter ⚠
- p.Ile170Ser Single submitter ⚠
- p.Ile231Thr Single submitter ⚠
- p.Ile231Val Single submitter ⚠
- p.Ile248Val Single submitter ⚠
- p.Ile266Val Single submitter ⚠
- p.Ile339Met Single submitter ⚠
- p.Ile398Val Single submitter ⚠
- p.Ile400Val Single submitter ⚠
- p.Ile487Asn Single submitter ⚠
- p.Ile508Thr Single submitter ⚠
- p.Ile608Met Single submitter ⚠
- p.Ile613Val Single submitter ⚠
- p.Leu488Met Single submitter ⚠
- p.Leu494Ser Single submitter ⚠
- p.Leu561Val Single submitter ⚠
- p.Leu752Pro Single submitter ⚠
- p.Leu90Trp Single submitter ⚠
- p.Lys209Arg Single submitter ⚠
- p.Lys371Glu Single submitter ⚠
- p.Lys436Glu Single submitter ⚠
- p.Met205Ile Single submitter ⚠
- p.Met285Val Single submitter ⚠
- p.Met567Thr Single submitter ⚠
- p.Met683Ile Single submitter ⚠
- p.Phe664Leu Single submitter ⚠
- p.Pro147Leu Single submitter ⚠
- p.Pro147Thr Single submitter ⚠
- p.Pro216Leu Single submitter ⚠
- p.Pro419Ser Single submitter ⚠
- p.Pro649Ser Single submitter ⚠
- p.Ser116Arg Single submitter ⚠
- p.Ser14Cys Single submitter ⚠
- p.Ser160Asn Single submitter ⚠
- p.Ser428Ile Single submitter ⚠
- p.Ser454Thr Single submitter ⚠
- p.Ser551Pro Single submitter ⚠
- p.Thr127Ile Single submitter ⚠
- p.Thr300Ile Single submitter ⚠
- p.Thr3Ile Single submitter ⚠
- p.Thr51Pro Single submitter ⚠
- p.Thr669Ala Single submitter ⚠
- p.Thr88Asn Single submitter ⚠
- p.Trp308Arg Single submitter ⚠
- p.Trp653Gly Single submitter ⚠
- p.Tyr210Cys Single submitter ⚠
- p.Tyr418Asn Single submitter ⚠
- p.Tyr625Cys Single submitter ⚠
- p.Tyr745Phe Single submitter ⚠
- p.Val549Ile Single submitter ⚠
- p.Val588Met Single submitter ⚠
- p.Val597Ile Single submitter ⚠
- p.Val597Phe Single submitter ⚠
- p.Val629Ile Single submitter ⚠