Sugi Variant

Sugi Variant/FAT1

FAT1 — 1786 ClinVar variants

All ClinVar germline FAT1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 661 flagged for review →

23 Pathogenic · 14 Likely pathogenic · 50 Conflicting · 120 Benign · 84 Benign/Likely benign · 519 Likely benign · 976 Uncertain significance

Full FAT1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 661

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors vs ClinVar 3

ClinVar calls these pathogenic, but the computational predictors lean tolerated — the highest-value review flag.

Predictors agree, ClinVar conflicts 40

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 581

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification. · showing the 150 best-reviewed of 581

Predictors split 37

The independent predictors disagree with each other — read with care.

All FAT1 variants

Pathogenic 23

Likely pathogenic 14

Conflicting classifications of pathogenicity 50

Benign 120

Benign/Likely benign 84

Likely benign 519

Showing the top 300 by review status; the full set is in the sitemap.

Uncertain significance 976

Showing the top 300 by review status; the full set is in the sitemap.