FBL — 39 ClinVar variants
All ClinVar germline FBL variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 36 flagged for review →
1 Benign · 1 Likely benign · 37 Uncertain significance
Full FBL gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 36
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 22
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- FBL p.Arg195His Uncertain significance Single submitter
- FBL p.Arg198His Uncertain significance Single submitter
- FBL p.Arg218Gln Uncertain significance Single submitter
- FBL p.Arg21Cys Uncertain significance Single submitter
- FBL p.Arg224His Uncertain significance Single submitter
- FBL p.Arg304Thr Uncertain significance Single submitter
- FBL p.Arg36Pro Uncertain significance Single submitter
- FBL p.Arg70Gly Uncertain significance Single submitter
- FBL p.Arg74Pro Uncertain significance Single submitter
- FBL p.Arg8Cys Uncertain significance Single submitter
- FBL p.Gly16Val Uncertain significance Single submitter
- FBL p.Gly54Ser Uncertain significance Single submitter
- FBL p.Gly55Arg Uncertain significance Single submitter
- FBL p.His93Arg Uncertain significance Single submitter
- FBL p.Ile148Val Uncertain significance Single submitter
- FBL p.Lys158Arg Uncertain significance Single submitter
- FBL p.Met87Thr Uncertain significance Single submitter
- FBL p.Phe97Leu Uncertain significance Single submitter
- FBL p.Pro159Leu Uncertain significance Single submitter
- FBL p.Pro90Leu Uncertain significance Single submitter
- FBL p.Ser82Leu Uncertain significance Single submitter
- FBL p.Val181Ala Uncertain significance Single submitter
Predictors split 14
The independent predictors disagree with each other — read with care.
- FBL p.Ala161Thr Uncertain significance Single submitter
- FBL p.Arg21His Uncertain significance Single submitter
- FBL p.Arg21Pro Uncertain significance Single submitter
- FBL p.Arg43Cys Uncertain significance Single submitter
- FBL p.Arg72His Uncertain significance Single submitter
- FBL p.Arg74Gln Uncertain significance Single submitter
- FBL p.Gly16Glu Uncertain significance Single submitter
- FBL p.Gly26Arg Uncertain significance Single submitter
- FBL p.Gly29Ala Uncertain significance Single submitter
- FBL p.Gly60Asp Uncertain significance Single submitter
- FBL p.Gly76Arg Uncertain significance Single submitter
- FBL p.Gly76Glu Uncertain significance Single submitter
- FBL p.Gly9Arg Uncertain significance Single submitter
- FBL p.Pro183Leu Uncertain significance Single submitter
All FBL variants
Benign 1
- p.Gly13= Multiple submitters
Likely benign 1
- p.Arg59Gly Single submitter
Uncertain significance 37
- p.Ala161Thr Single submitter ⚠
- p.Arg195His Single submitter ⚠
- p.Arg198His Single submitter ⚠
- p.Arg218Gln Single submitter ⚠
- p.Arg21Cys Single submitter ⚠
- p.Arg21His Single submitter ⚠
- p.Arg21Pro Single submitter ⚠
- p.Arg224His Single submitter ⚠
- p.Arg304Thr Single submitter ⚠
- p.Arg36Pro Single submitter ⚠
- p.Arg43Cys Single submitter ⚠
- p.Arg70Gly Single submitter ⚠
- p.Arg72His Single submitter ⚠
- p.Arg74Gln Single submitter ⚠
- p.Arg74Pro Single submitter ⚠
- p.Arg8Cys Single submitter ⚠
- p.Gly16Glu Single submitter ⚠
- p.Gly16Val Single submitter ⚠
- p.Gly26Arg Single submitter ⚠
- p.Gly29Ala Single submitter ⚠
- p.Gly54Ser Single submitter ⚠
- p.Gly55Arg Single submitter ⚠
- p.Gly60Asp Single submitter ⚠
- p.Gly76Arg Single submitter ⚠
- p.Gly76Glu Single submitter ⚠
- p.Gly9Arg Single submitter ⚠
- p.His93Arg Single submitter ⚠
- p.Ile148Val Single submitter ⚠
- p.Lys158Arg Single submitter ⚠
- p.Met87Thr Single submitter ⚠
- p.Phe97Leu Single submitter ⚠
- p.Pro159Leu Single submitter ⚠
- p.Pro183Leu Single submitter ⚠
- p.Pro90Leu Single submitter ⚠
- p.Ser82Leu Single submitter ⚠
- p.Thr252Ile Single submitter
- p.Val181Ala Single submitter ⚠