FBXL19 — 76 ClinVar variants
All ClinVar germline FBXL19 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 67 flagged for review →
3 Benign · 2 Likely benign · 71 Uncertain significance
Full FBXL19 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 67
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 58
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- FBXL19 p.Ala276Val Uncertain significance Multiple submitters
- FBXL19 p.Gly328Ser Uncertain significance Multiple submitters
- FBXL19 c.-8C>T Uncertain significance Single submitter
- FBXL19 p.Ala10Ser Uncertain significance Single submitter
- FBXL19 p.Ala10Thr Uncertain significance Single submitter
- FBXL19 p.Ala10Val Uncertain significance Single submitter
- FBXL19 p.Ala199Ser Uncertain significance Single submitter
- FBXL19 p.Ala326Val Uncertain significance Single submitter
- FBXL19 p.Ala369Val Uncertain significance Single submitter
- FBXL19 p.Ala408Thr Uncertain significance Single submitter
- FBXL19 p.Ala513Thr Uncertain significance Single submitter
- FBXL19 p.Ala588Thr Uncertain significance Single submitter
- FBXL19 p.Arg335Gln Uncertain significance Single submitter
- FBXL19 p.Arg347Cys Uncertain significance Single submitter
- FBXL19 p.Arg350Trp Uncertain significance Single submitter
- FBXL19 p.Arg351Trp Uncertain significance Single submitter
- FBXL19 p.Arg419Gln Uncertain significance Single submitter
- FBXL19 p.Arg419Trp Uncertain significance Single submitter
- FBXL19 p.Arg550Gln Uncertain significance Single submitter
- FBXL19 p.Arg635His Uncertain significance Single submitter
- FBXL19 p.Arg643His Uncertain significance Single submitter
- FBXL19 p.Arg663His Uncertain significance Single submitter
- FBXL19 p.Asn149Ile Uncertain significance Single submitter
- FBXL19 p.Asp401Tyr Uncertain significance Single submitter
- FBXL19 p.Cys253Phe Uncertain significance Single submitter
- FBXL19 p.Glu260Lys Uncertain significance Single submitter
- FBXL19 p.Glu85Asp Uncertain significance Single submitter
- FBXL19 p.Gly139Ser Uncertain significance Single submitter
- FBXL19 p.Gly222Ser Uncertain significance Single submitter
- FBXL19 p.Gly256Arg Uncertain significance Single submitter
- FBXL19 p.Gly274Ser Uncertain significance Single submitter
- FBXL19 p.Gly348Arg Uncertain significance Single submitter
- FBXL19 p.Gly507Cys Uncertain significance Single submitter
- FBXL19 p.His64Arg Uncertain significance Single submitter
- FBXL19 p.Leu156Met Uncertain significance Single submitter
- FBXL19 p.Leu362Phe Uncertain significance Single submitter
- FBXL19 p.Lys176Gln Uncertain significance Single submitter
- FBXL19 p.Pro142Arg Uncertain significance Single submitter
- FBXL19 p.Pro167Ser Uncertain significance Single submitter
- FBXL19 p.Pro183Ser Uncertain significance Single submitter
- FBXL19 p.Pro184Leu Uncertain significance Single submitter
- FBXL19 p.Pro185Ala Uncertain significance Single submitter
- FBXL19 p.Pro185Arg Uncertain significance Single submitter
- FBXL19 p.Pro185Leu Uncertain significance Single submitter
- FBXL19 p.Pro203Ala Uncertain significance Single submitter
- FBXL19 p.Pro206Leu Uncertain significance Single submitter
- FBXL19 p.Pro236Leu Uncertain significance Single submitter
- FBXL19 p.Pro246Leu Uncertain significance Single submitter
- FBXL19 p.Pro267Leu Uncertain significance Single submitter
- FBXL19 p.Pro327Ser Uncertain significance Single submitter
- FBXL19 p.Pro375Leu Uncertain significance Single submitter
- FBXL19 p.Pro455Ser Uncertain significance Single submitter
- FBXL19 p.Ser304Thr Uncertain significance Single submitter
- FBXL19 p.Ser322Arg Uncertain significance Single submitter
- FBXL19 p.Ser51Leu Uncertain significance Single submitter
- FBXL19 p.Thr540Ser Uncertain significance Single submitter
- FBXL19 p.Val101Ile Uncertain significance Single submitter
- FBXL19 p.Val554Leu Uncertain significance Single submitter
Predictors split 9
The independent predictors disagree with each other — read with care.
- FBXL19 p.Arg289His Uncertain significance Single submitter
- FBXL19 p.Arg289Leu Uncertain significance Single submitter
- FBXL19 p.Arg379Gln Uncertain significance Single submitter
- FBXL19 p.Asp315Val Uncertain significance Single submitter
- FBXL19 p.Glu523Lys Uncertain significance Single submitter
- FBXL19 p.Glu81Lys Uncertain significance Single submitter
- FBXL19 p.Ile100Val Uncertain significance Single submitter
- FBXL19 p.Lys526Glu Uncertain significance Single submitter
- FBXL19 p.Phe413Leu Uncertain significance Single submitter
All FBXL19 variants
Benign 3
- p.Arg652Gln Multiple submitters
- p.Gly177= Multiple submitters
- p.Ser51= Single submitter
Uncertain significance 71
- p.Ala276Val Multiple submitters ⚠
- p.Gly328Ser Multiple submitters ⚠
- c.177+1G>A Single submitter
- c.-8C>T Single submitter ⚠
- p.Ala10Ser Single submitter ⚠
- p.Ala10Thr Single submitter ⚠
- p.Ala10Val Single submitter ⚠
- p.Ala12fs Single submitter Neurodevelopmental delay
- p.Ala199Ser Single submitter ⚠
- p.Ala326Val Single submitter ⚠
- p.Ala369Val Single submitter ⚠
- p.Ala408Thr Single submitter ⚠
- p.Ala513Thr Single submitter ⚠
- p.Ala588Thr Single submitter ⚠
- p.Arg289His Single submitter ⚠
- p.Arg289Leu Single submitter ⚠
- p.Arg335Gln Single submitter ⚠
- p.Arg347Cys Single submitter ⚠
- p.Arg350Trp Single submitter ⚠
- p.Arg351Trp Single submitter ⚠
- p.Arg379Gln Single submitter ⚠
- p.Arg419Gln Single submitter ⚠
- p.Arg419Trp Single submitter ⚠
- p.Arg550Gln Single submitter ⚠
- p.Arg630His Single submitter
- p.Arg635His Single submitter ⚠
- p.Arg643His Single submitter ⚠
- p.Arg663His Single submitter ⚠
- p.Asn149Ile Single submitter ⚠
- p.Asp315Val Single submitter ⚠
- p.Asp401Tyr Single submitter ⚠
- p.Cys253Phe Single submitter ⚠
- p.Glu260Lys Single submitter ⚠
- p.Glu523Lys Single submitter ⚠
- p.Glu81Lys Single submitter ⚠
- p.Glu85Asp Single submitter ⚠
- p.Gly139Ser Single submitter ⚠
- p.Gly222Ser Single submitter ⚠
- p.Gly256Arg Single submitter ⚠
- p.Gly274Ser Single submitter ⚠
- p.Gly348Arg Single submitter ⚠
- p.Gly507Cys Single submitter ⚠
- p.His402fs Single submitter
- p.His64Arg Single submitter ⚠
- p.Ile100Val Single submitter ⚠
- p.Leu156Met Single submitter ⚠
- p.Leu362Phe Single submitter ⚠
- p.Lys176Gln Single submitter ⚠
- p.Lys526Glu Single submitter ⚠
- p.Phe413Leu Single submitter ⚠
- p.Pro142Arg Single submitter ⚠
- p.Pro167Ser Single submitter ⚠
- p.Pro183Ser Single submitter ⚠
- p.Pro184Leu Single submitter ⚠
- p.Pro185Ala Single submitter ⚠
- p.Pro185Arg Single submitter ⚠
- p.Pro185Leu Single submitter ⚠
- p.Pro203Ala Single submitter ⚠
- p.Pro206Leu Single submitter ⚠
- p.Pro236Leu Single submitter ⚠
- p.Pro246Leu Single submitter ⚠
- p.Pro267Leu Single submitter ⚠
- p.Pro327Ser Single submitter ⚠
- p.Pro375Leu Single submitter ⚠
- p.Pro455Ser Single submitter ⚠
- p.Ser304Thr Single submitter ⚠
- p.Ser322Arg Single submitter ⚠
- p.Ser51Leu Single submitter ⚠
- p.Thr540Ser Single submitter ⚠
- p.Val101Ile Single submitter ⚠
- p.Val554Leu Single submitter ⚠