FCGR1A — 44 ClinVar variants
All ClinVar germline FCGR1A variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 33 flagged for review →
1 Benign · 8 Likely benign · 35 Uncertain significance
Full FCGR1A gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 33
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 26
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- FCGR1A p.Ala121Val Uncertain significance Single submitter
- FCGR1A p.Ala263Gly Uncertain significance Single submitter
- FCGR1A p.Ala62Asp Uncertain significance Single submitter
- FCGR1A p.Arg112Thr Uncertain significance Single submitter
- FCGR1A p.Arg239Lys Uncertain significance Single submitter
- FCGR1A p.Arg314Cys Uncertain significance Single submitter
- FCGR1A p.Arg314Gly Uncertain significance Single submitter
- FCGR1A p.Asn159Thr Uncertain significance Single submitter
- FCGR1A p.Gln224Lys Uncertain significance Single submitter
- FCGR1A p.Gln356Arg Uncertain significance Single submitter
- FCGR1A p.Gln64Glu Uncertain significance Single submitter
- FCGR1A p.Glu277Asp Uncertain significance Single submitter
- FCGR1A p.Glu277Gln Uncertain significance Single submitter
- FCGR1A p.Glu348Lys Uncertain significance Single submitter
- FCGR1A p.Glu369Gln Uncertain significance Single submitter
- FCGR1A p.Gly364Ala Uncertain significance Single submitter
- FCGR1A p.Gly364Val Uncertain significance Single submitter
- FCGR1A p.Gly91Glu Uncertain significance Single submitter
- FCGR1A p.Leu341Phe Uncertain significance Single submitter
- FCGR1A p.Lys318Asn Uncertain significance Single submitter
- FCGR1A p.Met302Thr Uncertain significance Single submitter
- FCGR1A p.Thr158Ser Uncertain significance Single submitter
- FCGR1A p.Thr312Ile Uncertain significance Single submitter
- FCGR1A p.Thr312Lys Uncertain significance Single submitter
- FCGR1A p.Thr374Arg Uncertain significance Single submitter
- FCGR1A p.Val365Leu Uncertain significance Single submitter
Predictors split 7
The independent predictors disagree with each other — read with care.
- FCGR1A p.Arg175Cys Uncertain significance Single submitter
- FCGR1A p.Arg272Cys Uncertain significance Single submitter
- FCGR1A p.Arg84Gly Uncertain significance Single submitter
- FCGR1A p.Glu118Lys Uncertain significance Single submitter
- FCGR1A p.Gly170Asp Uncertain significance Single submitter
- FCGR1A p.Lys271Arg Uncertain significance Single submitter
- FCGR1A p.Val280Leu Uncertain significance Single submitter
All FCGR1A variants
Benign 1
- p.Glu359del Single submitter
Likely benign 8
- p.Ile338Thr Multiple submitters
- p.Leu7= Multiple submitters
- p.Thr38= Multiple submitters
- p.Ala373Gly Single submitter
- p.Asp129Asn Single submitter
- p.Lys352Ile Single submitter
- p.Met302Ile Single submitter
- p.Pro12= Single submitter
Uncertain significance 35
- p.Arg92Ter Multiple submitters FCGR1A-related disorder
- p.Ala121Val Single submitter ⚠
- p.Ala263Gly Single submitter ⚠
- p.Ala62Asp Single submitter ⚠
- p.Arg112Thr Single submitter ⚠
- p.Arg175Cys Single submitter ⚠
- p.Arg239Lys Single submitter ⚠
- p.Arg272Cys Single submitter ⚠
- p.Arg314Cys Single submitter ⚠
- p.Arg314Gly Single submitter ⚠
- p.Arg84Gly Single submitter ⚠
- p.Asn159Thr Single submitter ⚠
- p.Gln224Lys Single submitter ⚠
- p.Gln356Arg Single submitter ⚠
- p.Gln64Glu Single submitter ⚠
- p.Glu118Lys Single submitter ⚠
- p.Glu277Asp Single submitter ⚠
- p.Glu277Gln Single submitter ⚠
- p.Glu348Lys Single submitter ⚠
- p.Glu369Gln Single submitter ⚠
- p.Gly170Asp Single submitter ⚠
- p.Gly364Ala Single submitter ⚠
- p.Gly364Val Single submitter ⚠
- p.Gly91Glu Single submitter ⚠
- p.Leu341Phe Single submitter ⚠
- p.Lys271Arg Single submitter ⚠
- p.Lys318Asn Single submitter ⚠
- p.Met302Thr Single submitter ⚠
- p.Thr158Ser Single submitter ⚠
- p.Thr312Ile Single submitter ⚠
- p.Thr312Lys Single submitter ⚠
- p.Thr374Arg Single submitter ⚠
- p.Val280Leu Single submitter ⚠
- p.Val365Leu Single submitter ⚠
- p.Gln246Ter No assertion criteria Peritoneal Gliomatosis