FCGR3B — 49 ClinVar variants
All ClinVar germline FCGR3B variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 35 flagged for review →
3 Benign · 10 Likely benign · 36 Uncertain significance
Full FCGR3B gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 35
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 19
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- FCGR3B p.Ala195Thr Uncertain significance Single submitter
- FCGR3B p.Ala79Thr Uncertain significance Single submitter
- FCGR3B p.Arg173Lys Uncertain significance Single submitter
- FCGR3B p.Asn56Ser Uncertain significance Single submitter
- FCGR3B p.Gln192His Uncertain significance Single submitter
- FCGR3B p.Ile233Val Uncertain significance Single submitter
- FCGR3B p.Ile67Thr Uncertain significance Single submitter
- FCGR3B p.Leu217Val Uncertain significance Single submitter
- FCGR3B p.Leu66Phe Uncertain significance Single submitter
- FCGR3B p.Lys119Asn Uncertain significance Single submitter
- FCGR3B p.Phe227Tyr Uncertain significance Single submitter
- FCGR3B p.Pro114Ser Uncertain significance Single submitter
- FCGR3B p.Pro123Leu Uncertain significance Single submitter
- FCGR3B p.Ser197Leu Uncertain significance Single submitter
- FCGR3B p.Ser52Thr Uncertain significance Single submitter
- FCGR3B p.Ser57Phe Uncertain significance Single submitter
- FCGR3B p.Ser72Leu Uncertain significance Single submitter
- FCGR3B p.Trp116Gly Uncertain significance Single submitter
- FCGR3B p.Val27Leu Uncertain significance Single submitter
Predictors split 16
The independent predictors disagree with each other — read with care.
- FCGR3B p.Ala162Thr Uncertain significance Single submitter
- FCGR3B p.Ala220Glu Uncertain significance Single submitter
- FCGR3B p.Arg88Thr Uncertain significance Single submitter
- FCGR3B p.Asp83Glu Uncertain significance Single submitter
- FCGR3B p.Gly168Ser Uncertain significance Single submitter
- FCGR3B p.Gly49Val Uncertain significance Single submitter
- FCGR3B p.His137Pro Uncertain significance Single submitter
- FCGR3B p.Leu45Val Uncertain significance Single submitter
- FCGR3B p.Lys138Glu Uncertain significance Single submitter
- FCGR3B p.Lys138Thr Uncertain significance Single submitter
- FCGR3B p.Phe171Leu Uncertain significance Single submitter
- FCGR3B p.Pro99Leu Uncertain significance Single submitter
- FCGR3B p.Ser97Asn Uncertain significance Single submitter
- FCGR3B p.Thr191Pro Uncertain significance Single submitter
- FCGR3B p.Val139Ala Uncertain significance Single submitter
- FCGR3B p.Val209Gly Uncertain significance Single submitter
All FCGR3B variants
Benign 3
- p.Asn65Ser Multiple submitters
- p.Ile106Val Multiple submitters
- p.Val104= Single submitter
Likely benign 10
- p.Glu184= Single submitter
- p.Gly174= Single submitter
- p.His158Tyr Single submitter
- p.Leu136= Single submitter
- p.Met18Thr Single submitter
- p.Ser167= Single submitter
- p.Ser69Asn Single submitter
- p.Thr198Ser Single submitter
- p.Val176Phe Single submitter
- c.62-6C>A No assertion criteria
Uncertain significance 36
- p.Ala162Thr Single submitter ⚠
- p.Ala195Thr Single submitter ⚠
- p.Ala220Glu Single submitter ⚠
- p.Ala79Thr Single submitter ⚠
- p.Arg173Lys Single submitter ⚠
- p.Arg88Thr Single submitter ⚠
- p.Asn56Ser Single submitter ⚠
- p.Asp83Glu Single submitter ⚠
- p.Gln192His Single submitter ⚠
- p.Gly168Ser Single submitter ⚠
- p.Gly49Val Single submitter ⚠
- p.His137Pro Single submitter ⚠
- p.Ile233Val Single submitter ⚠
- p.Ile67Thr Single submitter ⚠
- p.Ile76Thr Single submitter
- p.Leu217Val Single submitter ⚠
- p.Leu45Val Single submitter ⚠
- p.Leu66Phe Single submitter ⚠
- p.Lys119Asn Single submitter ⚠
- p.Lys138Glu Single submitter ⚠
- p.Lys138Thr Single submitter ⚠
- p.Phe171Leu Single submitter ⚠
- p.Phe227Tyr Single submitter ⚠
- p.Pro114Ser Single submitter ⚠
- p.Pro123Leu Single submitter ⚠
- p.Pro99Leu Single submitter ⚠
- p.Ser197Leu Single submitter ⚠
- p.Ser52Thr Single submitter ⚠
- p.Ser57Phe Single submitter ⚠
- p.Ser72Leu Single submitter ⚠
- p.Ser97Asn Single submitter ⚠
- p.Thr191Pro Single submitter ⚠
- p.Trp116Gly Single submitter ⚠
- p.Val139Ala Single submitter ⚠
- p.Val209Gly Single submitter ⚠
- p.Val27Leu Single submitter ⚠