FCGRT — 54 ClinVar variants
All ClinVar germline FCGRT variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 50 flagged for review →
3 Benign · 1 Likely benign · 50 Uncertain significance
Full FCGRT gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 50
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 36
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- FCGRT p.Ala280Thr Uncertain significance Single submitter
- FCGRT p.Ala280Val Uncertain significance Single submitter
- FCGRT p.Ala283Thr Uncertain significance Single submitter
- FCGRT p.Ala283Val Uncertain significance Single submitter
- FCGRT p.Ala294Gly Uncertain significance Single submitter
- FCGRT p.Ala350Thr Uncertain significance Single submitter
- FCGRT p.Ala365Thr Uncertain significance Single submitter
- FCGRT p.Arg185His Uncertain significance Single submitter
- FCGRT p.Arg194His Uncertain significance Single submitter
- FCGRT p.Arg194Leu Uncertain significance Single submitter
- FCGRT p.Arg336His Uncertain significance Single submitter
- FCGRT p.Arg65Gln Uncertain significance Single submitter
- FCGRT p.Arg65Gly Uncertain significance Single submitter
- FCGRT p.Asn172Lys Uncertain significance Single submitter
- FCGRT p.Asp339Ala Uncertain significance Single submitter
- FCGRT p.Asp339Asn Uncertain significance Single submitter
- FCGRT p.Glu349Gly Uncertain significance Single submitter
- FCGRT p.Gly106Arg Uncertain significance Single submitter
- FCGRT p.Gly250Ser Uncertain significance Single submitter
- FCGRT p.Gly306Ser Uncertain significance Single submitter
- FCGRT p.Gly317Val Uncertain significance Single submitter
- FCGRT p.Leu175Phe Uncertain significance Single submitter
- FCGRT p.Leu18Phe Uncertain significance Single submitter
- FCGRT p.Leu197Met Uncertain significance Single submitter
- FCGRT p.Leu22Pro Uncertain significance Single submitter
- FCGRT p.Leu319Met Uncertain significance Single submitter
- FCGRT p.Leu343Phe Uncertain significance Single submitter
- FCGRT p.Pro123Ser Uncertain significance Single submitter
- FCGRT p.Pro202Ala Uncertain significance Single submitter
- FCGRT p.Pro203His Uncertain significance Single submitter
- FCGRT p.Pro329Arg Uncertain significance Single submitter
- FCGRT p.Pro42Leu Uncertain significance Single submitter
- FCGRT p.Pro6Arg Uncertain significance Single submitter
- FCGRT p.Ser204Cys Uncertain significance Single submitter
- FCGRT p.Thr264Ile Uncertain significance Single submitter
- FCGRT p.Val307Ala Uncertain significance Single submitter
Predictors split 14
The independent predictors disagree with each other — read with care.
- FCGRT p.Ala68Val Uncertain significance Single submitter
- FCGRT p.Glu270Asp Uncertain significance Single submitter
- FCGRT p.Gly193Cys Uncertain significance Single submitter
- FCGRT p.Gly243Ser Uncertain significance Single submitter
- FCGRT p.Gly243Val Uncertain significance Single submitter
- FCGRT p.Gly245Ser Uncertain significance Single submitter
- FCGRT p.Gly51Ser Uncertain significance Single submitter
- FCGRT p.His279Gln Uncertain significance Single submitter
- FCGRT p.Leu121Pro Uncertain significance Single submitter
- FCGRT p.Leu286Phe Uncertain significance Single submitter
- FCGRT p.Pro129Leu Uncertain significance Single submitter
- FCGRT p.Pro183Arg Uncertain significance Single submitter
- FCGRT p.Pro183Ser Uncertain significance Single submitter
- FCGRT p.Tyr111Cys Uncertain significance Single submitter
All FCGRT variants
Benign 3
- p.Lys132Asn Multiple submitters
- p.Pro42= Multiple submitters
- p.Thr340= Multiple submitters
Likely benign 1
- p.Thr311Met Single submitter
Uncertain significance 50
- p.Ala280Thr Single submitter ⚠
- p.Ala280Val Single submitter ⚠
- p.Ala283Thr Single submitter ⚠
- p.Ala283Val Single submitter ⚠
- p.Ala294Gly Single submitter ⚠
- p.Ala350Thr Single submitter ⚠
- p.Ala365Thr Single submitter ⚠
- p.Ala68Val Single submitter ⚠
- p.Arg185His Single submitter ⚠
- p.Arg194His Single submitter ⚠
- p.Arg194Leu Single submitter ⚠
- p.Arg336His Single submitter ⚠
- p.Arg65Gln Single submitter ⚠
- p.Arg65Gly Single submitter ⚠
- p.Asn172Lys Single submitter ⚠
- p.Asp339Ala Single submitter ⚠
- p.Asp339Asn Single submitter ⚠
- p.Glu270Asp Single submitter ⚠
- p.Glu349Gly Single submitter ⚠
- p.Gly106Arg Single submitter ⚠
- p.Gly193Cys Single submitter ⚠
- p.Gly243Ser Single submitter ⚠
- p.Gly243Val Single submitter ⚠
- p.Gly245Ser Single submitter ⚠
- p.Gly250Ser Single submitter ⚠
- p.Gly306Ser Single submitter ⚠
- p.Gly317Val Single submitter ⚠
- p.Gly51Ser Single submitter ⚠
- p.His279Gln Single submitter ⚠
- p.Leu121Pro Single submitter ⚠
- p.Leu175Phe Single submitter ⚠
- p.Leu18Phe Single submitter ⚠
- p.Leu197Met Single submitter ⚠
- p.Leu22Pro Single submitter ⚠
- p.Leu286Phe Single submitter ⚠
- p.Leu319Met Single submitter ⚠
- p.Leu343Phe Single submitter ⚠
- p.Pro123Ser Single submitter ⚠
- p.Pro129Leu Single submitter ⚠
- p.Pro183Arg Single submitter ⚠
- p.Pro183Ser Single submitter ⚠
- p.Pro202Ala Single submitter ⚠
- p.Pro203His Single submitter ⚠
- p.Pro329Arg Single submitter ⚠
- p.Pro42Leu Single submitter ⚠
- p.Pro6Arg Single submitter ⚠
- p.Ser204Cys Single submitter ⚠
- p.Thr264Ile Single submitter ⚠
- p.Tyr111Cys Single submitter ⚠
- p.Val307Ala Single submitter ⚠