FEN1 — 36 ClinVar variants
All ClinVar germline FEN1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 31 flagged for review →
1 Likely benign · 35 Uncertain significance
Full FEN1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 31
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 22
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- FEN1 p.Ala368Thr Uncertain significance Single submitter
- FEN1 p.Ala98Val Uncertain significance Single submitter
-
FEN1 p.Arg104Gln
Uncertain significance
Single submitter
hereditary breast ovarian cancer syndrome
- FEN1 p.Arg19Trp Uncertain significance Single submitter
- FEN1 p.Arg261Gln Uncertain significance Single submitter
- FEN1 p.Arg47Cys Uncertain significance Single submitter
- FEN1 p.Arg47His Uncertain significance Single submitter
- FEN1 p.Arg73His Uncertain significance Single submitter
- FEN1 p.Asp225Tyr Uncertain significance Single submitter
- FEN1 p.Glu300Lys Uncertain significance Single submitter
- FEN1 p.Gly217Asp Uncertain significance Single submitter
- FEN1 p.Gly348Ser Uncertain significance Single submitter
- FEN1 p.Gly58Asp Uncertain significance Single submitter
- FEN1 p.Gly78Ser Uncertain significance Single submitter
- FEN1 p.Ile321Thr Uncertain significance Single submitter
- FEN1 p.Leu190Pro Uncertain significance Single submitter
- FEN1 p.Met65Val Uncertain significance Single submitter
- FEN1 p.Phe316Tyr Uncertain significance Single submitter
- FEN1 p.Pro286Ala Uncertain significance Single submitter
- FEN1 p.Ser299Asn Uncertain significance Single submitter
- FEN1 p.Val84Ile Uncertain significance Single submitter
-
FEN1 p.Cys235Tyr
Uncertain significance
No assertion criteria
non-immune hydrops fetalis
Predictors split 9
The independent predictors disagree with each other — read with care.
- FEN1 p.Arg129Gln Uncertain significance Single submitter
- FEN1 p.Arg239Gln Uncertain significance Single submitter
- FEN1 p.Arg322Cys Uncertain significance Single submitter
- FEN1 p.Glu122Gln Uncertain significance Single submitter
- FEN1 p.Glu257Gln Uncertain significance Single submitter
- FEN1 p.Ile321Met Uncertain significance Single submitter
- FEN1 p.Phe185Tyr Uncertain significance Single submitter
- FEN1 p.Phe309Leu Uncertain significance Single submitter
- FEN1 p.Val189Met Uncertain significance Single submitter
All FEN1 variants
Likely benign 1
- p.Pro81= Single submitter
Uncertain significance 35
- p.Ala368Thr Single submitter ⚠
- p.Ala98Val Single submitter ⚠
- p.Arg103Gln Single submitter
- p.Arg104Gln Single submitter hereditary breast ovarian cancer syndrome ⚠
- p.Arg129Gln Single submitter ⚠
- p.Arg19Trp Single submitter ⚠
- p.Arg239Gln Single submitter ⚠
- p.Arg261Gln Single submitter ⚠
- p.Arg322Cys Single submitter ⚠
- p.Arg332His Single submitter
- p.Arg47Cys Single submitter ⚠
- p.Arg47His Single submitter ⚠
- p.Arg73His Single submitter ⚠
- p.Asp225Tyr Single submitter ⚠
- p.Glu122Gln Single submitter ⚠
- p.Glu257Gln Single submitter ⚠
- p.Glu300Lys Single submitter ⚠
- p.Gly217Asp Single submitter ⚠
- p.Gly348Ser Single submitter ⚠
- p.Gly58Asp Single submitter ⚠
- p.Gly78Ser Single submitter ⚠
- p.Ile321Met Single submitter ⚠
- p.Ile321Thr Single submitter ⚠
- p.Leu190Pro Single submitter ⚠
- p.Met65Val Single submitter ⚠
- p.Phe185Tyr Single submitter ⚠
- p.Phe309Leu Single submitter ⚠
- p.Phe316Tyr Single submitter ⚠
- p.Pro286Ala Single submitter ⚠
- p.Ser299Asn Single submitter ⚠
- p.Thr184Ser Single submitter
- p.Val189Met Single submitter ⚠
- p.Val288Met Single submitter
- p.Val84Ile Single submitter ⚠
- p.Cys235Tyr No assertion criteria non-immune hydrops fetalis ⚠