FERMT2 — 72 ClinVar variants
All ClinVar germline FERMT2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 63 flagged for review →
2 Likely benign · 70 Uncertain significance
Full FERMT2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 63
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 48
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- FERMT2 p.Ala537Val Uncertain significance Single submitter
- FERMT2 p.Arg273Gln Uncertain significance Single submitter
- FERMT2 p.Arg424Lys Uncertain significance Single submitter
- FERMT2 p.Arg525Cys Uncertain significance Single submitter
- FERMT2 p.Arg595Leu Uncertain significance Single submitter
- FERMT2 p.Asn249Ser Uncertain significance Single submitter
- FERMT2 p.Asn267Ser Uncertain significance Single submitter
- FERMT2 p.Asp30Asn Uncertain significance Single submitter
- FERMT2 p.Asp662Glu Uncertain significance Single submitter
- FERMT2 p.Cys127Ser Uncertain significance Single submitter
- FERMT2 p.Cys406Tyr Uncertain significance Single submitter
- FERMT2 p.Gln394Arg Uncertain significance Single submitter
- FERMT2 p.Gln578His Uncertain significance Single submitter
- FERMT2 p.Glu461Lys Uncertain significance Single submitter
- FERMT2 p.Gly360Asp Uncertain significance Single submitter
- FERMT2 p.Gly360Val Uncertain significance Single submitter
- FERMT2 p.Gly601Val Uncertain significance Single submitter
- FERMT2 p.His134Gln Uncertain significance Single submitter
- FERMT2 p.His196Arg Uncertain significance Single submitter
- FERMT2 p.His23Tyr Uncertain significance Single submitter
- FERMT2 p.His419Tyr Uncertain significance Single submitter
- FERMT2 p.Ile220Val Uncertain significance Single submitter
- FERMT2 p.Ile365Val Uncertain significance Single submitter
- FERMT2 p.Ile441Val Uncertain significance Single submitter
- FERMT2 p.Ile516Val Uncertain significance Single submitter
- FERMT2 p.Ile552Phe Uncertain significance Single submitter
- FERMT2 p.Ile574Val Uncertain significance Single submitter
- FERMT2 p.Ile604Val Uncertain significance Single submitter
- FERMT2 p.Leu493Ile Uncertain significance Single submitter
- FERMT2 p.Leu99Val Uncertain significance Single submitter
- FERMT2 p.Lys150Arg Uncertain significance Single submitter
- FERMT2 p.Lys154Gln Uncertain significance Single submitter
- FERMT2 p.Lys531Arg Uncertain significance Single submitter
- FERMT2 p.Lys661Arg Uncertain significance Single submitter
- FERMT2 p.Lys67Thr Uncertain significance Single submitter
- FERMT2 p.Met189Val Uncertain significance Single submitter
- FERMT2 p.Phe573Ser Uncertain significance Single submitter
- FERMT2 p.Pro417Arg Uncertain significance Single submitter
- FERMT2 p.Pro417Gln Uncertain significance Single submitter
- FERMT2 p.Ser124Phe Uncertain significance Single submitter
- FERMT2 p.Ser175Thr Uncertain significance Single submitter
- FERMT2 p.Ser21Thr Uncertain significance Single submitter
- FERMT2 p.Ser494Cys Uncertain significance Single submitter
- FERMT2 p.Thr190Asn Uncertain significance Single submitter
- FERMT2 p.Thr416Ile Uncertain significance Single submitter
- FERMT2 p.Thr600Ile Uncertain significance Single submitter
- FERMT2 p.Trp615Arg Uncertain significance Single submitter
- FERMT2 p.Val432Ala Uncertain significance Single submitter
Predictors split 15
The independent predictors disagree with each other — read with care.
- FERMT2 p.Ala298Gly Uncertain significance Single submitter
- FERMT2 p.Ala481Val Uncertain significance Single submitter
- FERMT2 p.Arg595Gln Uncertain significance Single submitter
- FERMT2 p.Asn292Ser Uncertain significance Single submitter
- FERMT2 p.Asp630His Uncertain significance Single submitter
- FERMT2 p.Gly168Glu Uncertain significance Single submitter
- FERMT2 p.Gly415Val Uncertain significance Single submitter
- FERMT2 p.Ile171Thr Uncertain significance Single submitter
- FERMT2 p.Ile574Ser Uncertain significance Single submitter
- FERMT2 p.Pro9Leu Uncertain significance Single submitter
- FERMT2 p.Pro9Ser Uncertain significance Single submitter
- FERMT2 p.Ser435Leu Uncertain significance Single submitter
- FERMT2 p.Thr188Arg Uncertain significance Single submitter
- FERMT2 p.Tyr185Cys Uncertain significance Single submitter
- FERMT2 p.Tyr526Cys Uncertain significance Single submitter
All FERMT2 variants
Likely benign 2
- c.1603-560A>G Single submitter
- p.Gly359= Single submitter
Uncertain significance 70
- c.1603-562A>G Single submitter
- c.1603-565G>C Single submitter
- c.1603-566G>C Single submitter
- p.Ala122Gly Single submitter
- p.Ala298Gly Single submitter ⚠
- p.Ala481Val Single submitter ⚠
- p.Ala537Val Single submitter ⚠
- p.Arg273Gln Single submitter ⚠
- p.Arg424Lys Single submitter ⚠
- p.Arg525Cys Single submitter ⚠
- p.Arg595Gln Single submitter ⚠
- p.Arg595Leu Single submitter ⚠
- p.Asn249Ser Single submitter ⚠
- p.Asn267Ser Single submitter ⚠
- p.Asn292Ser Single submitter ⚠
- p.Asp30Asn Single submitter ⚠
- p.Asp630His Single submitter ⚠
- p.Asp662Glu Single submitter ⚠
- p.Cys127Ser Single submitter ⚠
- p.Cys406Tyr Single submitter ⚠
- p.Gln394Arg Single submitter ⚠
- p.Gln499Ter Single submitter
- p.Gln578His Single submitter ⚠
- p.Glu461Lys Single submitter ⚠
- p.Gly168Glu Single submitter ⚠
- p.Gly360Asp Single submitter ⚠
- p.Gly360Val Single submitter ⚠
- p.Gly415Val Single submitter ⚠
- p.Gly601Val Single submitter ⚠
- p.His134Gln Single submitter ⚠
- p.His196Arg Single submitter ⚠
- p.His23Tyr Single submitter ⚠
- p.His419Tyr Single submitter ⚠
- p.Ile171Thr Single submitter ⚠
- p.Ile220Val Single submitter ⚠
- p.Ile365Val Single submitter ⚠
- p.Ile441Val Single submitter ⚠
- p.Ile516Thr Single submitter
- p.Ile516Val Single submitter ⚠
- p.Ile552Phe Single submitter ⚠
- p.Ile574Ser Single submitter ⚠
- p.Ile574Val Single submitter ⚠
- p.Ile604Val Single submitter ⚠
- p.Leu493Ile Single submitter ⚠
- p.Leu99Val Single submitter ⚠
- p.Lys150Arg Single submitter ⚠
- p.Lys154Gln Single submitter ⚠
- p.Lys531Arg Single submitter ⚠
- p.Lys661Arg Single submitter ⚠
- p.Lys67Thr Single submitter ⚠
- p.Met189Val Single submitter ⚠
- p.Phe573Ser Single submitter ⚠
- p.Pro417Arg Single submitter ⚠
- p.Pro417Gln Single submitter ⚠
- p.Pro9Leu Single submitter ⚠
- p.Pro9Ser Single submitter ⚠
- p.Ser124Phe Single submitter ⚠
- p.Ser175Thr Single submitter ⚠
- p.Ser21Thr Single submitter ⚠
- p.Ser435Leu Single submitter ⚠
- p.Ser494Cys Single submitter ⚠
- p.Thr188Arg Single submitter ⚠
- p.Thr190Asn Single submitter ⚠
- p.Thr416Ile Single submitter ⚠
- p.Thr600Ile Single submitter ⚠
- p.Trp615Arg Single submitter ⚠
- p.Tyr185Cys Single submitter ⚠
- p.Tyr392Cys Single submitter
- p.Tyr526Cys Single submitter ⚠
- p.Val432Ala Single submitter ⚠