FES — 128 ClinVar variants
All ClinVar germline FES variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 115 flagged for review →
3 Benign · 6 Likely benign · 119 Uncertain significance
Full FES gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 115
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 95
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- FES p.Ala22Asp Uncertain significance Single submitter
- FES p.Ala243Val Uncertain significance Single submitter
- FES p.Ala45Pro Uncertain significance Single submitter
- FES p.Ala548Pro Uncertain significance Single submitter
- FES p.Arg154His Uncertain significance Single submitter
- FES p.Arg185Cys Uncertain significance Single submitter
- FES p.Arg210Trp Uncertain significance Single submitter
- FES p.Arg254His Uncertain significance Single submitter
- FES p.Arg327Gln Uncertain significance Single submitter
- FES p.Arg327Trp Uncertain significance Single submitter
- FES p.Arg348Gln Uncertain significance Single submitter
- FES p.Arg348Gly Uncertain significance Single submitter
- FES p.Arg37Trp Uncertain significance Single submitter
- FES p.Arg406Cys Uncertain significance Single submitter
- FES p.Arg406His Uncertain significance Single submitter
- FES p.Arg502Gln Uncertain significance Single submitter
- FES p.Arg547Lys Uncertain significance Single submitter
- FES p.Arg579His Uncertain significance Single submitter
- FES p.Arg581Gln Uncertain significance Single submitter
- FES p.Arg649Leu Uncertain significance Single submitter
- FES p.Arg656Gln Uncertain significance Single submitter
- FES p.Arg687Trp Uncertain significance Single submitter
- FES p.Arg778Cys Uncertain significance Single submitter
- FES p.Arg818Gln Uncertain significance Single submitter
- FES p.Arg820Trp Uncertain significance Single submitter
- FES p.Arg822Gln Uncertain significance Single submitter
- FES p.Arg822Trp Uncertain significance Single submitter
- FES p.Arg85His Uncertain significance Single submitter
- FES p.Arg88Trp Uncertain significance Single submitter
- FES p.Asn511Ser Uncertain significance Single submitter
- FES p.Asn733His Uncertain significance Single submitter
- FES p.Gln198His Uncertain significance Single submitter
- FES p.Gln202Glu Uncertain significance Single submitter
- FES p.Gln403His Uncertain significance Single submitter
- FES p.Gln59His Uncertain significance Single submitter
- FES p.Gln79Pro Uncertain significance Single submitter
- FES p.Glu217Lys Uncertain significance Single submitter
- FES p.Glu225Asp Uncertain significance Single submitter
- FES p.Glu341Lys Uncertain significance Single submitter
- FES p.Glu343Gly Uncertain significance Single submitter
- FES p.Glu349Asp Uncertain significance Single submitter
- FES p.Glu417Asp Uncertain significance Single submitter
- FES p.Glu607Lys Uncertain significance Single submitter
- FES p.Glu774Gly Uncertain significance Single submitter
- FES p.Gly207Asp Uncertain significance Single submitter
- FES p.Gly29Arg Uncertain significance Single submitter
- FES p.Gly418Ala Uncertain significance Single submitter
- FES p.Gly418Arg Uncertain significance Single submitter
- FES p.Gly418Trp Uncertain significance Single submitter
- FES p.Gly419Glu Uncertain significance Single submitter
- FES p.Gly641Ala Uncertain significance Single submitter
- FES p.Gly652Arg Uncertain significance Single submitter
- FES p.Gly652Trp Uncertain significance Single submitter
- FES p.Gly652Val Uncertain significance Single submitter
- FES p.Gly665Glu Uncertain significance Single submitter
- FES p.Gly82Asp Uncertain significance Single submitter
- FES p.His456Arg Uncertain significance Single submitter
- FES p.Ile619Phe Uncertain significance Single submitter
- FES p.Ile623Leu Uncertain significance Single submitter
- FES p.Ile634Leu Uncertain significance Single submitter
- FES p.Ile810Val Uncertain significance Single submitter
- FES p.Leu105Val Uncertain significance Single submitter
- FES p.Leu195Val Uncertain significance Single submitter
- FES p.Leu622Val Uncertain significance Single submitter
- FES p.Lys694Asn Uncertain significance Single submitter
- FES p.Met248Ile Uncertain significance Single submitter
- FES p.Met323Leu Uncertain significance Single submitter
- FES p.Pro290Leu Uncertain significance Single submitter
- FES p.Pro397Arg Uncertain significance Single submitter
- FES p.Pro397Leu Uncertain significance Single submitter
- FES p.Pro449Leu Uncertain significance Single submitter
- FES p.Pro466Thr Uncertain significance Single submitter
- FES p.Pro723Arg Uncertain significance Single submitter
- FES p.Ser160Asn Uncertain significance Single submitter
- FES p.Ser175Gly Uncertain significance Single submitter
- FES p.Ser412Leu Uncertain significance Single submitter
- FES p.Ser52Phe Uncertain significance Single submitter
- FES p.Ser5Phe Uncertain significance Single submitter
- FES p.Ser67Gly Uncertain significance Single submitter
- FES p.Ser9Asn Uncertain significance Single submitter
- FES p.Thr279Lys Uncertain significance Single submitter
- FES p.Thr279Met Uncertain significance Single submitter
- FES p.Thr332Met Uncertain significance Single submitter
- FES p.Thr423Met Uncertain significance Single submitter
- FES p.Tyr142Phe Uncertain significance Single submitter
- FES p.Tyr461His Uncertain significance Single submitter
- FES p.Tyr633Ser Uncertain significance Single submitter
- FES p.Tyr761Cys Uncertain significance Single submitter
- FES p.Val242Leu Uncertain significance Single submitter
- FES p.Val306Met Uncertain significance Single submitter
- FES p.Val359Met Uncertain significance Single submitter
- FES p.Val562Leu Uncertain significance Single submitter
- FES p.Val620Met Uncertain significance Single submitter
- FES p.Val712Phe Uncertain significance Single submitter
- FES p.Val743Leu Uncertain significance Single submitter
Predictors split 20
The independent predictors disagree with each other — read with care.
- FES p.Ala192Pro Uncertain significance Single submitter
- FES p.Ala370Val Uncertain significance Single submitter
- FES p.Ala548Val Uncertain significance Single submitter
- FES p.Ala91Thr Uncertain significance Single submitter
- FES p.Arg147Trp Uncertain significance Single submitter
- FES p.Arg165Cys Uncertain significance Single submitter
- FES p.Arg165His Uncertain significance Single submitter
- FES p.Arg191Trp Uncertain significance Single submitter
- FES p.Arg621His Uncertain significance Single submitter
- FES p.Arg736Cys Uncertain significance Single submitter
- FES p.Gln54Pro Uncertain significance Single submitter
- FES p.Glu118Lys Uncertain significance Single submitter
- FES p.Glu287Gly Uncertain significance Single submitter
- FES p.Glu342Asp Uncertain significance Single submitter
- FES p.Glu559Lys Uncertain significance Single submitter
- FES p.Ile634Val Uncertain significance Single submitter
- FES p.Met636Thr Uncertain significance Single submitter
- FES p.Pro437Leu Uncertain significance Single submitter
- FES p.Ser9Arg Uncertain significance Single submitter
- FES p.Val190Met Uncertain significance Single submitter
All FES variants
Benign 3
- p.Ala588= Multiple submitters
- p.Leu459= Multiple submitters
- p.Met323Val Multiple submitters
Likely benign 6
- p.Ala271Thr Single submitter
- p.Arg266Gln Single submitter
- p.Gly642= Single submitter
- p.Met330Val Single submitter
- p.Val543Ile Single submitter
- p.Val544Ile Single submitter
Uncertain significance 119
- p.Ala192Pro Single submitter ⚠
- p.Ala22Asp Single submitter ⚠
- p.Ala243Val Single submitter ⚠
- p.Ala370Val Single submitter ⚠
- p.Ala45Pro Single submitter ⚠
- p.Ala548Pro Single submitter ⚠
- p.Ala548Val Single submitter ⚠
- p.Ala91Thr Single submitter ⚠
- p.Arg147Trp Single submitter ⚠
- p.Arg154His Single submitter ⚠
- p.Arg165Cys Single submitter ⚠
- p.Arg165His Single submitter ⚠
- p.Arg185Cys Single submitter ⚠
- p.Arg191Trp Single submitter ⚠
- p.Arg210Trp Single submitter ⚠
- p.Arg254His Single submitter ⚠
- p.Arg327Gln Single submitter ⚠
- p.Arg327Trp Single submitter ⚠
- p.Arg348Gln Single submitter ⚠
- p.Arg348Gly Single submitter ⚠
- p.Arg37Trp Single submitter ⚠
- p.Arg406Cys Single submitter ⚠
- p.Arg406His Single submitter ⚠
- p.Arg502Gln Single submitter ⚠
- p.Arg547Lys Single submitter ⚠
- p.Arg579His Single submitter ⚠
- p.Arg581Gln Single submitter ⚠
- p.Arg621His Single submitter ⚠
- p.Arg649Leu Single submitter ⚠
- p.Arg656Gln Single submitter ⚠
- p.Arg687Trp Single submitter ⚠
- p.Arg736Cys Single submitter ⚠
- p.Arg778Cys Single submitter ⚠
- p.Arg818Gln Single submitter ⚠
- p.Arg820Trp Single submitter ⚠
- p.Arg822Gln Single submitter ⚠
- p.Arg822Trp Single submitter ⚠
- p.Arg85His Single submitter ⚠
- p.Arg88Trp Single submitter ⚠
- p.Asn511Ser Single submitter ⚠
- p.Asn733His Single submitter ⚠
- p.Gln198His Single submitter ⚠
- p.Gln202Glu Single submitter ⚠
- p.Gln403His Single submitter ⚠
- p.Gln54Pro Single submitter ⚠
- p.Gln59His Single submitter ⚠
- p.Gln79Pro Single submitter ⚠
- p.Glu118Lys Single submitter ⚠
- p.Glu217Lys Single submitter ⚠
- p.Glu225Asp Single submitter ⚠
- p.Glu287Gly Single submitter ⚠
- p.Glu341Lys Single submitter ⚠
- p.Glu342Asp Single submitter ⚠
- p.Glu343Gly Single submitter ⚠
- p.Glu349Asp Single submitter ⚠
- p.Glu417Asp Single submitter ⚠
- p.Glu559Lys Single submitter ⚠
- p.Glu607Lys Single submitter ⚠
- p.Glu774Gly Single submitter ⚠
- p.Gly207Asp Single submitter ⚠
- p.Gly29Arg Single submitter ⚠
- p.Gly418Ala Single submitter ⚠
- p.Gly418Arg Single submitter ⚠
- p.Gly418Trp Single submitter ⚠
- p.Gly419Glu Single submitter ⚠
- p.Gly641Ala Single submitter ⚠
- p.Gly652Arg Single submitter ⚠
- p.Gly652Trp Single submitter ⚠
- p.Gly652Val Single submitter ⚠
- p.Gly665Glu Single submitter ⚠
- p.Gly82Asp Single submitter ⚠
- p.His456Arg Single submitter ⚠
- p.Ile619Phe Single submitter ⚠
- p.Ile623Leu Single submitter ⚠
- p.Ile634Leu Single submitter ⚠
- p.Ile634Val Single submitter ⚠
- p.Ile810Val Single submitter ⚠
- p.Leu105Val Single submitter ⚠
- p.Leu195Val Single submitter ⚠
- p.Leu622Val Single submitter ⚠
- p.Lys629Glu Single submitter
- p.Lys694Asn Single submitter ⚠
- p.Met248Ile Single submitter ⚠
- p.Met323Leu Single submitter ⚠
- p.Met636Thr Single submitter ⚠
- p.Pro290Leu Single submitter ⚠
- p.Pro397Arg Single submitter ⚠
- p.Pro397Leu Single submitter ⚠
- p.Pro437Leu Single submitter ⚠
- p.Pro449Leu Single submitter ⚠
- p.Pro466Thr Single submitter ⚠
- p.Pro723Arg Single submitter ⚠
- p.Ser160Asn Single submitter ⚠
- p.Ser175Gly Single submitter ⚠
- p.Ser412Leu Single submitter ⚠
- p.Ser52Phe Single submitter ⚠
- p.Ser5Phe Single submitter ⚠
- p.Ser67Gly Single submitter ⚠
- p.Ser755Gly Single submitter
- p.Ser9Arg Single submitter ⚠
- p.Ser9Asn Single submitter ⚠
- p.Thr279Lys Single submitter ⚠
- p.Thr279Met Single submitter ⚠
- p.Thr332Met Single submitter ⚠
- p.Thr423Met Single submitter ⚠
- p.Trp497Gly Single submitter
- p.Tyr142Phe Single submitter ⚠
- p.Tyr461His Single submitter ⚠
- p.Tyr633Ser Single submitter ⚠
- p.Tyr761Cys Single submitter ⚠
- p.Val190Met Single submitter ⚠
- p.Val242Leu Single submitter ⚠
- p.Val306Met Single submitter ⚠
- p.Val359Met Single submitter ⚠
- p.Val562Leu Single submitter ⚠
- p.Val620Met Single submitter ⚠
- p.Val712Phe Single submitter ⚠
- p.Val743Leu Single submitter ⚠
- p.Val789Met Single submitter