FFAR2 — 79 ClinVar variants
All ClinVar germline FFAR2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 75 flagged for review →
2 Benign · 2 Likely benign · 75 Uncertain significance
Full FFAR2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 75
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 44
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- FFAR2 p.Ala101Glu Uncertain significance Single submitter
- FFAR2 p.Ala101Pro Uncertain significance Single submitter
- FFAR2 p.Ala307Thr Uncertain significance Single submitter
- FFAR2 p.Ala42Ser Uncertain significance Single submitter
- FFAR2 p.Arg107Cys Uncertain significance Single submitter
- FFAR2 p.Arg107His Uncertain significance Single submitter
- FFAR2 p.Arg121Gly Uncertain significance Single submitter
- FFAR2 p.Arg121Ser Uncertain significance Single submitter
- FFAR2 p.Arg292Trp Uncertain significance Single submitter
- FFAR2 p.Arg302Lys Uncertain significance Single submitter
- FFAR2 p.Arg35Leu Uncertain significance Single submitter
- FFAR2 p.Arg74His Uncertain significance Single submitter
- FFAR2 p.Asp170Asn Uncertain significance Single submitter
- FFAR2 p.Asp326Val Uncertain significance Single submitter
- FFAR2 p.Asp55Tyr Uncertain significance Single submitter
- FFAR2 p.Cys198Ser Uncertain significance Single submitter
- FFAR2 p.Glu106Lys Uncertain significance Single submitter
- FFAR2 p.Glu182Lys Uncertain significance Single submitter
- FFAR2 p.Gly126Arg Uncertain significance Single submitter
- FFAR2 p.Gly236Arg Uncertain significance Single submitter
- FFAR2 p.Gly315Arg Uncertain significance Single submitter
- FFAR2 p.Gly315Val Uncertain significance Single submitter
- FFAR2 p.Gly317Val Uncertain significance Single submitter
- FFAR2 p.Gly319Arg Uncertain significance Single submitter
- FFAR2 p.Ile16Thr Uncertain significance Single submitter
- FFAR2 p.Ile16Val Uncertain significance Single submitter
- FFAR2 p.Ile17Val Uncertain significance Single submitter
- FFAR2 p.Ile46Thr Uncertain significance Single submitter
- FFAR2 p.Leu229Phe Uncertain significance Single submitter
- FFAR2 p.Leu84Phe Uncertain significance Single submitter
- FFAR2 p.Phe202Val Uncertain significance Single submitter
- FFAR2 p.Pro114Ser Uncertain significance Single submitter
- FFAR2 p.Pro270Ala Uncertain significance Single submitter
- FFAR2 p.Pro323Thr Uncertain significance Single submitter
- FFAR2 p.Ser276Pro Uncertain significance Single submitter
- FFAR2 p.Ser325Leu Uncertain significance Single submitter
- FFAR2 p.Thr142Ile Uncertain significance Single submitter
- FFAR2 p.Thr306Arg Uncertain significance Single submitter
- FFAR2 p.Val115Glu Uncertain significance Single submitter
- FFAR2 p.Val156Ile Uncertain significance Single submitter
- FFAR2 p.Val175Met Uncertain significance Single submitter
- FFAR2 p.Val212Leu Uncertain significance Single submitter
- FFAR2 p.Val290Met Uncertain significance Single submitter
- FFAR2 p.Val81Ile Uncertain significance Single submitter
Predictors split 31
The independent predictors disagree with each other — read with care.
- FFAR2 p.Ala112Val Uncertain significance Single submitter
- FFAR2 p.Ala13Val Uncertain significance Single submitter
- FFAR2 p.Arg122Gln Uncertain significance Single submitter
- FFAR2 p.Arg122Gly Uncertain significance Single submitter
- FFAR2 p.Arg217Gln Uncertain significance Single submitter
- FFAR2 p.Arg218Cys Uncertain significance Single submitter
- FFAR2 p.Arg219Gln Uncertain significance Single submitter
- FFAR2 p.Arg281His Uncertain significance Single submitter
- FFAR2 p.Arg281Leu Uncertain significance Single submitter
- FFAR2 p.Arg292Gln Uncertain significance Single submitter
- FFAR2 p.Arg37Cys Uncertain significance Single submitter
- FFAR2 p.Arg37Leu Uncertain significance Single submitter
- FFAR2 p.Asn230His Uncertain significance Single submitter
- FFAR2 p.Asn25Ser Uncertain significance Single submitter
- FFAR2 p.Gln294His Uncertain significance Single submitter
- FFAR2 p.Glu166Gly Uncertain significance Single submitter
- FFAR2 p.Gly321Trp Uncertain significance Single submitter
- FFAR2 p.Gly88Arg Uncertain significance Single submitter
- FFAR2 p.Ile15Met Uncertain significance Single submitter
- FFAR2 p.Ile205Thr Uncertain significance Single submitter
- FFAR2 p.Leu131Pro Uncertain significance Single submitter
- FFAR2 p.Phe138Leu Uncertain significance Single submitter
- FFAR2 p.Ser50Thr Uncertain significance Single submitter
- FFAR2 p.Ser92Asn Uncertain significance Single submitter
- FFAR2 p.Thr152Ala Uncertain significance Single submitter
- FFAR2 p.Thr169Ala Uncertain significance Single submitter
- FFAR2 p.Thr227Met Uncertain significance Single submitter
- FFAR2 p.Val179Met Uncertain significance Single submitter
- FFAR2 p.Val194Leu Uncertain significance Single submitter
- FFAR2 p.Val203Gly Uncertain significance Single submitter
- FFAR2 p.Val259Met Uncertain significance Single submitter
All FFAR2 variants
Benign 2
- p.Arg35= Single submitter
- p.Ile46Val Single submitter
Likely benign 2
- p.Gln40His Single submitter
- p.His247Tyr Single submitter
Uncertain significance 75
- p.Ala101Glu Single submitter ⚠
- p.Ala101Pro Single submitter ⚠
- p.Ala112Val Single submitter ⚠
- p.Ala13Val Single submitter ⚠
- p.Ala307Thr Single submitter ⚠
- p.Ala42Ser Single submitter ⚠
- p.Arg107Cys Single submitter ⚠
- p.Arg107His Single submitter ⚠
- p.Arg121Gly Single submitter ⚠
- p.Arg121Ser Single submitter ⚠
- p.Arg122Gln Single submitter ⚠
- p.Arg122Gly Single submitter ⚠
- p.Arg217Gln Single submitter ⚠
- p.Arg218Cys Single submitter ⚠
- p.Arg219Gln Single submitter ⚠
- p.Arg281His Single submitter ⚠
- p.Arg281Leu Single submitter ⚠
- p.Arg292Gln Single submitter ⚠
- p.Arg292Trp Single submitter ⚠
- p.Arg302Lys Single submitter ⚠
- p.Arg35Leu Single submitter ⚠
- p.Arg37Cys Single submitter ⚠
- p.Arg37Leu Single submitter ⚠
- p.Arg74His Single submitter ⚠
- p.Asn230His Single submitter ⚠
- p.Asn25Ser Single submitter ⚠
- p.Asp170Asn Single submitter ⚠
- p.Asp326Val Single submitter ⚠
- p.Asp55Tyr Single submitter ⚠
- p.Cys198Ser Single submitter ⚠
- p.Gln294His Single submitter ⚠
- p.Glu106Lys Single submitter ⚠
- p.Glu166Gly Single submitter ⚠
- p.Glu182Lys Single submitter ⚠
- p.Gly126Arg Single submitter ⚠
- p.Gly236Arg Single submitter ⚠
- p.Gly315Arg Single submitter ⚠
- p.Gly315Val Single submitter ⚠
- p.Gly317Val Single submitter ⚠
- p.Gly319Arg Single submitter ⚠
- p.Gly321Trp Single submitter ⚠
- p.Gly88Arg Single submitter ⚠
- p.Ile15Met Single submitter ⚠
- p.Ile16Thr Single submitter ⚠
- p.Ile16Val Single submitter ⚠
- p.Ile17Val Single submitter ⚠
- p.Ile205Thr Single submitter ⚠
- p.Ile46Thr Single submitter ⚠
- p.Leu131Pro Single submitter ⚠
- p.Leu229Phe Single submitter ⚠
- p.Leu84Phe Single submitter ⚠
- p.Phe138Leu Single submitter ⚠
- p.Phe202Val Single submitter ⚠
- p.Pro114Ser Single submitter ⚠
- p.Pro270Ala Single submitter ⚠
- p.Pro323Thr Single submitter ⚠
- p.Ser276Pro Single submitter ⚠
- p.Ser325Leu Single submitter ⚠
- p.Ser50Thr Single submitter ⚠
- p.Ser92Asn Single submitter ⚠
- p.Thr142Ile Single submitter ⚠
- p.Thr152Ala Single submitter ⚠
- p.Thr169Ala Single submitter ⚠
- p.Thr227Met Single submitter ⚠
- p.Thr306Arg Single submitter ⚠
- p.Val115Glu Single submitter ⚠
- p.Val156Ile Single submitter ⚠
- p.Val175Met Single submitter ⚠
- p.Val179Met Single submitter ⚠
- p.Val194Leu Single submitter ⚠
- p.Val203Gly Single submitter ⚠
- p.Val212Leu Single submitter ⚠
- p.Val259Met Single submitter ⚠
- p.Val290Met Single submitter ⚠
- p.Val81Ile Single submitter ⚠