FFAR3 — 84 ClinVar variants
All ClinVar germline FFAR3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 69 flagged for review →
2 Benign · 10 Likely benign · 72 Uncertain significance
Full FFAR3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 69
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 55
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- FFAR3 p.Ala103Thr Uncertain significance Single submitter
- FFAR3 p.Ala224Val Uncertain significance Single submitter
- FFAR3 p.Ala285Asp Uncertain significance Single submitter
- FFAR3 p.Ala320Val Uncertain significance Single submitter
- FFAR3 p.Ala35Asp Uncertain significance Single submitter
- FFAR3 p.Ala49Thr Uncertain significance Single submitter
- FFAR3 p.Ala59Thr Uncertain significance Single submitter
- FFAR3 p.Arg113Cys Uncertain significance Single submitter
- FFAR3 p.Arg128Ser Uncertain significance Single submitter
- FFAR3 p.Arg185Pro Uncertain significance Single submitter
- FFAR3 p.Arg218Cys Uncertain significance Single submitter
- FFAR3 p.Arg258Ser Uncertain significance Single submitter
- FFAR3 p.Arg322Leu Uncertain significance Single submitter
- FFAR3 p.Asn13Ser Uncertain significance Single submitter
- FFAR3 p.Asn166His Uncertain significance Single submitter
- FFAR3 p.Asn56Ile Uncertain significance Single submitter
- FFAR3 p.Asp286Val Uncertain significance Single submitter
- FFAR3 p.Asp2Asn Uncertain significance Single submitter
- FFAR3 p.Asp51Glu Uncertain significance Single submitter
- FFAR3 p.Asp6Asn Uncertain significance Single submitter
- FFAR3 p.Cys295Tyr Uncertain significance Single submitter
- FFAR3 p.Gln318His Uncertain significance Single submitter
- FFAR3 p.Glu74Lys Uncertain significance Single submitter
- FFAR3 p.Gly12Arg Uncertain significance Single submitter
- FFAR3 p.Gly215Cys Uncertain significance Single submitter
- FFAR3 p.Gly28Arg Uncertain significance Single submitter
- FFAR3 p.Gly299Ala Uncertain significance Single submitter
- FFAR3 p.Gly299Ser Uncertain significance Single submitter
- FFAR3 p.Gly334Asp Uncertain significance Single submitter
- FFAR3 p.Gly338Cys Uncertain significance Single submitter
- FFAR3 p.His14Tyr Uncertain significance Single submitter
- FFAR3 p.His288Arg Uncertain significance Single submitter
- FFAR3 p.Ile210Phe Uncertain significance Single submitter
- FFAR3 p.Ile259Val Uncertain significance Single submitter
- FFAR3 p.Leu106Pro Uncertain significance Single submitter
- FFAR3 p.Leu181Pro Uncertain significance Single submitter
- FFAR3 p.Leu263Phe Uncertain significance Single submitter
- FFAR3 p.Lys42Arg Uncertain significance Single submitter
- FFAR3 p.Met307Leu Uncertain significance Single submitter
- FFAR3 p.Met72Val Uncertain significance Single submitter
- FFAR3 p.Met79Val Uncertain significance Single submitter
- FFAR3 p.Phe274Val Uncertain significance Single submitter
- FFAR3 p.Phe85Tyr Uncertain significance Single submitter
- FFAR3 p.Pro82Arg Uncertain significance Single submitter
- FFAR3 p.Ser205Arg Uncertain significance Single submitter
- FFAR3 p.Thr58Asn Uncertain significance Single submitter
- FFAR3 p.Trp122Arg Uncertain significance Single submitter
- FFAR3 p.Trp257Arg Uncertain significance Single submitter
- FFAR3 p.Val149Met Uncertain significance Single submitter
- FFAR3 p.Val184Met Uncertain significance Single submitter
- FFAR3 p.Val236Phe Uncertain significance Single submitter
- FFAR3 p.Val247Met Uncertain significance Single submitter
- FFAR3 p.Val27Met Uncertain significance Single submitter
- FFAR3 p.Val40Leu Uncertain significance Single submitter
- FFAR3 p.Val50Ala Uncertain significance Single submitter
Predictors split 14
The independent predictors disagree with each other — read with care.
- FFAR3 p.Ala228Glu Uncertain significance Single submitter
- FFAR3 p.Arg185Gln Uncertain significance Single submitter
- FFAR3 p.Arg219Trp Uncertain significance Single submitter
- FFAR3 p.Arg71Cys Uncertain significance Single submitter
- FFAR3 p.Asn233Tyr Uncertain significance Single submitter
- FFAR3 p.Asp61Asn Uncertain significance Single submitter
- FFAR3 p.Gln177Lys Uncertain significance Single submitter
- FFAR3 p.Leu22Ile Uncertain significance Single submitter
- FFAR3 p.Met72Thr Uncertain significance Single submitter
- FFAR3 p.Met79Ile Uncertain significance Single submitter
- FFAR3 p.Pro255Leu Uncertain significance Single submitter
- FFAR3 p.Pro84Arg Uncertain significance Single submitter
- FFAR3 p.Pro84Leu Uncertain significance Single submitter
- FFAR3 p.Ser116Asn Uncertain significance Single submitter
All FFAR3 variants
Benign 2
- p.Arg45His Multiple submitters
- p.Met307Val Multiple submitters
Likely benign 10
- p.Ala256= Multiple submitters
- p.Ser201= Multiple submitters
- p.Ala320= Single submitter
- p.Arg174Gln Single submitter
- p.Gly212Ser Single submitter
- p.Gly282Arg Single submitter
- p.Lys175Glu Single submitter
- p.Thr262Met Single submitter
- p.Val152Ile Single submitter
- p.Val243Met Single submitter
Uncertain significance 72
- p.Ala103Thr Single submitter ⚠
- p.Ala224Val Single submitter ⚠
- p.Ala228Glu Single submitter ⚠
- p.Ala285Asp Single submitter ⚠
- p.Ala320Val Single submitter ⚠
- p.Ala35Asp Single submitter ⚠
- p.Ala49Thr Single submitter ⚠
- p.Ala59Thr Single submitter ⚠
- p.Arg113Cys Single submitter ⚠
- p.Arg128Ser Single submitter ⚠
- p.Arg185Gln Single submitter ⚠
- p.Arg185Pro Single submitter ⚠
- p.Arg218Cys Single submitter ⚠
- p.Arg219Trp Single submitter ⚠
- p.Arg258Ser Single submitter ⚠
- p.Arg322Leu Single submitter ⚠
- p.Arg71Cys Single submitter ⚠
- p.Asn13Ser Single submitter ⚠
- p.Asn166His Single submitter ⚠
- p.Asn233Tyr Single submitter ⚠
- p.Asn56Ile Single submitter ⚠
- p.Asp286Val Single submitter ⚠
- p.Asp2Asn Single submitter ⚠
- p.Asp51Glu Single submitter ⚠
- p.Asp61Asn Single submitter ⚠
- p.Asp6Asn Single submitter ⚠
- p.Cys295Tyr Single submitter ⚠
- p.Gln177Lys Single submitter ⚠
- p.Gln318His Single submitter ⚠
- p.Glu74Lys Single submitter ⚠
- p.Gly12Arg Single submitter ⚠
- p.Gly215Cys Single submitter ⚠
- p.Gly28Arg Single submitter ⚠
- p.Gly299Ala Single submitter ⚠
- p.Gly299Ser Single submitter ⚠
- p.Gly334Asp Single submitter ⚠
- p.Gly338Cys Single submitter ⚠
- p.His14Tyr Single submitter ⚠
- p.His288Arg Single submitter ⚠
- p.Ile180Asn Single submitter
- p.Ile210Phe Single submitter ⚠
- p.Ile259Val Single submitter ⚠
- p.Leu106Pro Single submitter ⚠
- p.Leu181Pro Single submitter ⚠
- p.Leu22Ile Single submitter ⚠
- p.Leu263Phe Single submitter ⚠
- p.Leu66Pro Single submitter
- p.Lys42Arg Single submitter ⚠
- p.Met307Leu Single submitter ⚠
- p.Met72Thr Single submitter ⚠
- p.Met72Val Single submitter ⚠
- p.Met79Ile Single submitter ⚠
- p.Met79Val Single submitter ⚠
- p.Phe274Val Single submitter ⚠
- p.Phe85Tyr Single submitter ⚠
- p.Pro255Leu Single submitter ⚠
- p.Pro82Arg Single submitter ⚠
- p.Pro84Arg Single submitter ⚠
- p.Pro84Leu Single submitter ⚠
- p.Ser116Asn Single submitter ⚠
- p.Ser205Arg Single submitter ⚠
- p.Ser254Cys Single submitter
- p.Thr58Asn Single submitter ⚠
- p.Trp122Arg Single submitter ⚠
- p.Trp257Arg Single submitter ⚠
- p.Val149Met Single submitter ⚠
- p.Val184Met Single submitter ⚠
- p.Val236Phe Single submitter ⚠
- p.Val247Met Single submitter ⚠
- p.Val27Met Single submitter ⚠
- p.Val40Leu Single submitter ⚠
- p.Val50Ala Single submitter ⚠