FFAR4 — 57 ClinVar variants
All ClinVar germline FFAR4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 44 flagged for review →
2 Benign · 6 Likely benign · 49 Uncertain significance
Full FFAR4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 44
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 37
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- FFAR4 p.Ala131Val Uncertain significance Single submitter
- FFAR4 p.Ala160Ser Uncertain significance Single submitter
- FFAR4 p.Ala167Val Uncertain significance Single submitter
- FFAR4 p.Ala315Thr Uncertain significance Single submitter
- FFAR4 p.Ala6Gly Uncertain significance Single submitter
- FFAR4 p.Arg136His Uncertain significance Single submitter
- FFAR4 p.Arg145His Uncertain significance Single submitter
- FFAR4 p.Arg148Gln Uncertain significance Single submitter
- FFAR4 p.Arg148Pro Uncertain significance Single submitter
- FFAR4 p.Arg183Leu Uncertain significance Single submitter
-
FFAR4 p.Arg254His
Uncertain significance
Single submitter
BODY MASS INDEX QUANTITATIVE TRAIT LOCUS 10
- FFAR4 p.Arg261Gln Uncertain significance Single submitter
- FFAR4 p.Arg36Trp Uncertain significance Single submitter
- FFAR4 p.Asp348Gly Uncertain significance Single submitter
- FFAR4 p.Asp355Gly Uncertain significance Single submitter
- FFAR4 p.Cys174Ser Uncertain significance Single submitter
- FFAR4 p.Gln252Glu Uncertain significance Single submitter
- FFAR4 p.Gln252His Uncertain significance Single submitter
- FFAR4 p.Gly164Ser Uncertain significance Single submitter
- FFAR4 p.Leu268His Uncertain significance Single submitter
- FFAR4 p.Leu325Met Uncertain significance Single submitter
- FFAR4 p.Leu81Phe Uncertain significance Single submitter
- FFAR4 p.Lys352Glu Uncertain significance Single submitter
- FFAR4 p.Pro300Leu Uncertain significance Single submitter
- FFAR4 p.Pro300Ser Uncertain significance Single submitter
- FFAR4 p.Pro3Ala Uncertain significance Single submitter
- FFAR4 p.Pro93Ser Uncertain significance Single submitter
- FFAR4 p.Ser133Asn Uncertain significance Single submitter
- FFAR4 p.Ser248Leu Uncertain significance Single submitter
- FFAR4 p.Ser2Thr Uncertain significance Single submitter
- FFAR4 p.Ser357Leu Uncertain significance Single submitter
- FFAR4 p.Thr283Ile Uncertain significance Single submitter
- FFAR4 p.Thr74Ile Uncertain significance Single submitter
- FFAR4 p.Val48Met Uncertain significance Single submitter
- FFAR4 p.Val59Leu Uncertain significance Single submitter
- FFAR4 p.Val65Ala Uncertain significance Single submitter
- FFAR4 p.Cys76Gly Uncertain significance No assertion criteria
Predictors split 7
The independent predictors disagree with each other — read with care.
- FFAR4 p.Arg261Trp Uncertain significance Single submitter
- FFAR4 p.Arg71Gly Uncertain significance Single submitter
- FFAR4 p.Arg99Ser Uncertain significance Single submitter
- FFAR4 p.Leu106Pro Uncertain significance Single submitter
- FFAR4 p.Leu266Phe Uncertain significance Single submitter
- FFAR4 p.Phe115Val Uncertain significance Single submitter
- FFAR4 p.Thr310Arg Uncertain significance Single submitter
All FFAR4 variants
Benign 2
- p.Gln257Arg Single submitter
- p.Ile333= Single submitter
Likely benign 6
- c.696+2973G>A Single submitter
- p.Ala73Thr Single submitter
- p.Ser192Leu Single submitter
- p.Thr200Ser Single submitter
- p.Val175Ile Single submitter
- p.Val38= Single submitter
Uncertain significance 49
- c.696+2944C>T Single submitter
- c.696+2949C>T Single submitter
- c.696+2974T>C Single submitter
- p.Ala131Val Single submitter ⚠
- p.Ala160Ser Single submitter ⚠
- p.Ala167Val Single submitter ⚠
- p.Ala315Thr Single submitter ⚠
- p.Ala6Gly Single submitter ⚠
- p.Arg136His Single submitter ⚠
- p.Arg145His Single submitter ⚠
- p.Arg148Gln Single submitter ⚠
- p.Arg148Pro Single submitter ⚠
- p.Arg183Leu Single submitter ⚠
- p.Arg254His Single submitter BODY MASS INDEX QUANTITATIVE TRAIT LOCUS 10 ⚠
- p.Arg261Gln Single submitter ⚠
- p.Arg261Trp Single submitter ⚠
- p.Arg36Trp Single submitter ⚠
- p.Arg71Gly Single submitter ⚠
- p.Arg99Ser Single submitter ⚠
- p.Asp348Gly Single submitter ⚠
- p.Asp355Gly Single submitter ⚠
- p.Cys174Ser Single submitter ⚠
- p.Gln252Glu Single submitter ⚠
- p.Gln252His Single submitter ⚠
- p.Gly164Ser Single submitter ⚠
- p.Leu106Pro Single submitter ⚠
- p.Leu266Phe Single submitter ⚠
- p.Leu268His Single submitter ⚠
- p.Leu325Met Single submitter ⚠
- p.Leu81Phe Single submitter ⚠
- p.Lys352Glu Single submitter ⚠
- p.Phe115Val Single submitter ⚠
- p.Pro300Leu Single submitter ⚠
- p.Pro300Ser Single submitter ⚠
- p.Pro3Ala Single submitter ⚠
- p.Pro93Ser Single submitter ⚠
- p.Ser133Asn Single submitter ⚠
- p.Ser248Leu Single submitter ⚠
- p.Ser2Thr Single submitter ⚠
- p.Ser357Leu Single submitter ⚠
- p.Thr283Ile Single submitter ⚠
- p.Thr310Arg Single submitter ⚠
- p.Thr74Ile Single submitter ⚠
- p.Trp305Cys Single submitter
- p.Val306Gly Single submitter
- p.Val48Met Single submitter ⚠
- p.Val59Leu Single submitter ⚠
- p.Val65Ala Single submitter ⚠
- p.Cys76Gly No assertion criteria ⚠