FGF1 — 16 ClinVar variants
All ClinVar germline FGF1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 16 flagged for review →
1 Benign · 15 Uncertain significance
Full FGF1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 16
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 8
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- FGF1 p.Arg134Pro Uncertain significance Single submitter
- FGF1 p.Cys132Gly Uncertain significance Single submitter
- FGF1 p.Gln78Arg Uncertain significance Single submitter
- FGF1 p.Glu14Gln Uncertain significance Single submitter
- FGF1 p.Gly34Arg Uncertain significance Single submitter
- FGF1 p.Lys27Arg Uncertain significance Single submitter
- FGF1 p.Ser73Asn Uncertain significance Single submitter
- FGF1 p.Thr13Asn Uncertain significance Single submitter
Predictors split 8
The independent predictors disagree with each other — read with care.
- FGF1 p.Ala118Pro Uncertain significance Single submitter
- FGF1 p.Arg137Gln Uncertain significance Single submitter
- FGF1 p.Asp47Gly Uncertain significance Single submitter
- FGF1 p.Glu96Gly Uncertain significance Single submitter
- FGF1 p.Gly21Glu Benign Single submitter
- FGF1 p.Gly90Ser Uncertain significance Single submitter
- FGF1 p.Lys115Thr Uncertain significance Single submitter
- FGF1 p.Phe9Ser Uncertain significance Single submitter
All FGF1 variants
Benign 1
- p.Gly21Glu Single submitter ⚠
Uncertain significance 15
- p.Ala118Pro Single submitter ⚠
- p.Arg134Pro Single submitter ⚠
- p.Arg137Gln Single submitter ⚠
- p.Asp47Gly Single submitter ⚠
- p.Cys132Gly Single submitter ⚠
- p.Gln78Arg Single submitter ⚠
- p.Glu14Gln Single submitter ⚠
- p.Glu96Gly Single submitter ⚠
- p.Gly34Arg Single submitter ⚠
- p.Gly90Ser Single submitter ⚠
- p.Lys115Thr Single submitter ⚠
- p.Lys27Arg Single submitter ⚠
- p.Phe9Ser Single submitter ⚠
- p.Ser73Asn Single submitter ⚠
- p.Thr13Asn Single submitter ⚠