FGR — 54 ClinVar variants
All ClinVar germline FGR variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 47 flagged for review →
3 Benign · 4 Likely benign · 47 Uncertain significance
Full FGR gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 47
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 20
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- FGR p.Ala30Thr Uncertain significance Single submitter
- FGR p.Ala395Thr Uncertain significance Single submitter
- FGR p.Ala60Thr Uncertain significance Single submitter
- FGR p.Ala60Val Uncertain significance Single submitter
- FGR p.Arg384Lys Uncertain significance Single submitter
- FGR p.Asn52Ser Uncertain significance Single submitter
- FGR p.Asp498Glu Uncertain significance Single submitter
- FGR p.Glu174Lys Uncertain significance Single submitter
- FGR p.Gly23Glu Uncertain significance Single submitter
- FGR p.His225Gln Uncertain significance Single submitter
- FGR p.Ile71Ser Uncertain significance Single submitter
- FGR p.Leu497Val Uncertain significance Single submitter
- FGR p.Lys397Asn Uncertain significance Single submitter
- FGR p.Met244Thr Uncertain significance Single submitter
- FGR p.Met310Thr Uncertain significance Single submitter
- FGR p.Phe505Leu Uncertain significance Single submitter
- FGR p.Ser443Pro Uncertain significance Single submitter
- FGR p.Val441Gly Uncertain significance Single submitter
- FGR p.Val79Leu Uncertain significance Single submitter
- FGR p.Pro525Ser Uncertain significance No assertion criteria
Predictors split 27
The independent predictors disagree with each other — read with care.
- FGR p.Arg465Trp Uncertain significance Single submitter
- FGR p.Arg496Cys Uncertain significance Single submitter
- FGR p.Cys127Trp Uncertain significance Single submitter
- FGR p.Gln157His Uncertain significance Single submitter
- FGR p.Glu327Ala Uncertain significance Single submitter
- FGR p.Glu489Lys Uncertain significance Single submitter
- FGR p.Gly101Asp Uncertain significance Single submitter
- FGR p.Gly207Ser Uncertain significance Single submitter
- FGR p.Gly35Trp Uncertain significance Single submitter
- FGR p.Ile149Thr Uncertain significance Single submitter
- FGR p.Ile258Met Uncertain significance Single submitter
- FGR p.Leu451Phe Uncertain significance Single submitter
- FGR p.Lys287Thr Uncertain significance Single submitter
- FGR p.Lys317Arg Uncertain significance Single submitter
- FGR p.Lys408Arg Uncertain significance Single submitter
- FGR p.Met310Leu Uncertain significance Single submitter
- FGR p.Pro11Leu Uncertain significance Single submitter
- FGR p.Pro161Leu Uncertain significance Single submitter
- FGR p.Pro460Leu Uncertain significance Single submitter
- FGR p.Pro478Leu Uncertain significance Single submitter
- FGR p.Pro521Leu Uncertain significance Single submitter
- FGR p.Ser218Leu Uncertain significance Single submitter
- FGR p.Thr14Met Uncertain significance Single submitter
- FGR p.Thr176Ile Uncertain significance Single submitter
- FGR p.Thr286Ala Uncertain significance Single submitter
- FGR p.Trp187Arg Uncertain significance Single submitter
- FGR p.Arg118Trp Uncertain significance No assertion criteria
All FGR variants
Benign 3
- c.533-8C>G Multiple submitters
- p.Asp254= Multiple submitters
- p.Ser122= Multiple submitters
Likely benign 4
- p.Ala19Val Single submitter
- p.Ala395Val Single submitter
- p.Arg42Gln Single submitter
- p.Asn217Ser Single submitter
Uncertain significance 47
- p.Ala30Thr Single submitter ⚠
- p.Ala395Thr Single submitter ⚠
- p.Ala60Thr Single submitter ⚠
- p.Ala60Val Single submitter ⚠
- p.Arg384Lys Single submitter ⚠
- p.Arg465Trp Single submitter ⚠
- p.Arg496Cys Single submitter ⚠
- p.Asn52Ser Single submitter ⚠
- p.Asp498Glu Single submitter ⚠
- p.Cys127Trp Single submitter ⚠
- p.Gln157His Single submitter ⚠
- p.Glu174Lys Single submitter ⚠
- p.Glu327Ala Single submitter ⚠
- p.Glu489Lys Single submitter ⚠
- p.Gly101Asp Single submitter ⚠
- p.Gly207Ser Single submitter ⚠
- p.Gly23Glu Single submitter ⚠
- p.Gly35Trp Single submitter ⚠
- p.His225Gln Single submitter ⚠
- p.Ile149Thr Single submitter ⚠
- p.Ile258Met Single submitter ⚠
- p.Ile71Ser Single submitter ⚠
- p.Leu451Phe Single submitter ⚠
- p.Leu497Val Single submitter ⚠
- p.Lys287Thr Single submitter ⚠
- p.Lys317Arg Single submitter ⚠
- p.Lys397Asn Single submitter ⚠
- p.Lys408Arg Single submitter ⚠
- p.Met244Thr Single submitter ⚠
- p.Met310Leu Single submitter ⚠
- p.Met310Thr Single submitter ⚠
- p.Phe505Leu Single submitter ⚠
- p.Pro11Leu Single submitter ⚠
- p.Pro161Leu Single submitter ⚠
- p.Pro460Leu Single submitter ⚠
- p.Pro478Leu Single submitter ⚠
- p.Pro521Leu Single submitter ⚠
- p.Ser218Leu Single submitter ⚠
- p.Ser443Pro Single submitter ⚠
- p.Thr14Met Single submitter ⚠
- p.Thr176Ile Single submitter ⚠
- p.Thr286Ala Single submitter ⚠
- p.Trp187Arg Single submitter ⚠
- p.Val441Gly Single submitter ⚠
- p.Val79Leu Single submitter ⚠
- p.Arg118Trp No assertion criteria ⚠
- p.Pro525Ser No assertion criteria ⚠