FKBP2 — 12 ClinVar variants
All ClinVar germline FKBP2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 11 flagged for review →
1 Likely benign · 11 Uncertain significance
Full FKBP2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 11
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 9
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- FKBP2 p.Arg139Gln Uncertain significance Single submitter
- FKBP2 p.His41Arg Uncertain significance Single submitter
- FKBP2 p.Ile136Thr Uncertain significance Single submitter
- FKBP2 p.Ile86Met Uncertain significance Single submitter
- FKBP2 p.Leu80Phe Uncertain significance Single submitter
- FKBP2 p.Met54Val Uncertain significance Single submitter
- FKBP2 p.Pro122Ala Uncertain significance Single submitter
- FKBP2 p.Thr140Ala Uncertain significance Single submitter
- FKBP2 p.Val51Ile Uncertain significance Single submitter
Predictors split 2
The independent predictors disagree with each other — read with care.
All FKBP2 variants
Likely benign 1
- c.-5+420G>A Single submitter
Uncertain significance 11
- p.Arg138Gln Single submitter ⚠
- p.Arg139Gln Single submitter ⚠
- p.His41Arg Single submitter ⚠
- p.Ile136Thr Single submitter ⚠
- p.Ile86Met Single submitter ⚠
- p.Leu80Phe Single submitter ⚠
- p.Met54Val Single submitter ⚠
- p.Pro122Ala Single submitter ⚠
- p.Thr140Ala Single submitter ⚠
- p.Val39Met Single submitter ⚠
- p.Val51Ile Single submitter ⚠