FKBP3 — 27 ClinVar variants
All ClinVar germline FKBP3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 26 flagged for review →
1 Likely benign · 26 Uncertain significance
Full FKBP3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 26
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 19
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- FKBP3 p.Arg16His Uncertain significance Single submitter
- FKBP3 p.Arg189Gln Uncertain significance Single submitter
- FKBP3 p.Asp205Tyr Uncertain significance Single submitter
- FKBP3 p.Asp57Gly Uncertain significance Single submitter
- FKBP3 p.Glu102Asp Uncertain significance Single submitter
- FKBP3 p.Glu217Ala Uncertain significance Single submitter
- FKBP3 p.Glu92Asp Uncertain significance Single submitter
- FKBP3 p.His132Tyr Uncertain significance Single submitter
- FKBP3 p.His65Arg Uncertain significance Single submitter
- FKBP3 p.Ile172Phe Uncertain significance Single submitter
- FKBP3 p.Ile25Val Uncertain significance Single submitter
- FKBP3 p.Ile47Val Uncertain significance Single submitter
- FKBP3 p.Lys127Arg Uncertain significance Single submitter
- FKBP3 p.Lys187Glu Uncertain significance Single submitter
- FKBP3 p.Met182Ile Uncertain significance Single submitter
- FKBP3 p.Pro6Thr Uncertain significance Single submitter
- FKBP3 p.Ser36Leu Uncertain significance Single submitter
- FKBP3 p.Ser77Asn Uncertain significance Single submitter
- FKBP3 p.Val171Phe Uncertain significance Single submitter
Predictors split 7
The independent predictors disagree with each other — read with care.
- FKBP3 p.Arg8Trp Uncertain significance Single submitter
- FKBP3 p.Gly33Arg Uncertain significance Single submitter
- FKBP3 p.Gly74Arg Uncertain significance Single submitter
- FKBP3 p.Leu90Phe Uncertain significance Single submitter
- FKBP3 p.Lys213Asn Uncertain significance Single submitter
- FKBP3 p.Lys52Gln Uncertain significance Single submitter
- FKBP3 p.Ser82Phe Uncertain significance Single submitter
All FKBP3 variants
Likely benign 1
- p.Ile78Val Single submitter
Uncertain significance 26
- p.Arg16His Single submitter ⚠
- p.Arg189Gln Single submitter ⚠
- p.Arg8Trp Single submitter ⚠
- p.Asp205Tyr Single submitter ⚠
- p.Asp57Gly Single submitter ⚠
- p.Glu102Asp Single submitter ⚠
- p.Glu217Ala Single submitter ⚠
- p.Glu92Asp Single submitter ⚠
- p.Gly33Arg Single submitter ⚠
- p.Gly74Arg Single submitter ⚠
- p.His132Tyr Single submitter ⚠
- p.His65Arg Single submitter ⚠
- p.Ile172Phe Single submitter ⚠
- p.Ile25Val Single submitter ⚠
- p.Ile47Val Single submitter ⚠
- p.Leu90Phe Single submitter ⚠
- p.Lys127Arg Single submitter ⚠
- p.Lys187Glu Single submitter ⚠
- p.Lys213Asn Single submitter ⚠
- p.Lys52Gln Single submitter ⚠
- p.Met182Ile Single submitter ⚠
- p.Pro6Thr Single submitter ⚠
- p.Ser36Leu Single submitter ⚠
- p.Ser77Asn Single submitter ⚠
- p.Ser82Phe Single submitter ⚠
- p.Val171Phe Single submitter ⚠