FKBP5 — 46 ClinVar variants
All ClinVar germline FKBP5 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 39 flagged for review →
3 Benign · 2 Likely benign · 41 Uncertain significance
Full FKBP5 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 39
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 31
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- FKBP5 p.Ala116Asp Uncertain significance Single submitter
- FKBP5 p.Ala268Thr Uncertain significance Single submitter
- FKBP5 p.Ala287Val Uncertain significance Single submitter
- FKBP5 p.Ala417Ser Uncertain significance Single submitter
- FKBP5 p.Arg175Cys Uncertain significance Single submitter
- FKBP5 p.Arg175His Uncertain significance Single submitter
- FKBP5 p.Asn350Ser Uncertain significance Single submitter
- FKBP5 p.Asn402Asp Uncertain significance Single submitter
- FKBP5 p.Asp195Asn Uncertain significance Single submitter
- FKBP5 p.Cys103Arg Uncertain significance Single submitter
- FKBP5 p.Glu423Ala Uncertain significance Single submitter
- FKBP5 p.Glu423Lys Uncertain significance Single submitter
- FKBP5 p.Glu44Lys Uncertain significance Single submitter
- FKBP5 p.Gly281Arg Uncertain significance Single submitter
- FKBP5 p.Ile102Arg Uncertain significance Single submitter
- FKBP5 p.Ile242Val Uncertain significance Single submitter
- FKBP5 p.Ile36Met Uncertain significance Single submitter
- FKBP5 p.Ile408Leu Uncertain significance Single submitter
- FKBP5 p.Leu81Ile Uncertain significance Single submitter
- FKBP5 p.Lys427Glu Uncertain significance Single submitter
- FKBP5 p.Lys441Glu Uncertain significance Single submitter
- FKBP5 p.Lys452Arg Uncertain significance Single submitter
- FKBP5 p.Met393Ile Uncertain significance Single submitter
- FKBP5 p.Met429Thr Uncertain significance Single submitter
- FKBP5 p.Ser249Asn Uncertain significance Single submitter
- FKBP5 p.Thr127Ser Uncertain significance Single submitter
- FKBP5 p.Thr15Arg Uncertain significance Single submitter
- FKBP5 p.Thr189Ala Uncertain significance Single submitter
- FKBP5 p.Thr246Ala Uncertain significance Single submitter
- FKBP5 p.Val288Leu Uncertain significance Single submitter
- FKBP5 p.Val437Ile Uncertain significance Single submitter
Predictors split 8
The independent predictors disagree with each other — read with care.
- FKBP5 p.Arg154Trp Uncertain significance Single submitter
- FKBP5 p.Arg406Cys Uncertain significance Single submitter
- FKBP5 p.Asn125Ser Uncertain significance Single submitter
- FKBP5 p.Ile36Thr Uncertain significance Single submitter
- FKBP5 p.Leu172Val Uncertain significance Single submitter
- FKBP5 p.Met48Ile Uncertain significance Single submitter
- FKBP5 p.Ser160Leu Uncertain significance Single submitter
- FKBP5 p.Val33Leu Uncertain significance Single submitter
All FKBP5 variants
Benign 3
- c.105+2542G>A Single submitter
- c.*1136G>T Single submitter
- p.Asp4= Single submitter
Likely benign 2
- p.Ser13Asn Single submitter
- p.Val437Phe Single submitter
Uncertain significance 41
- p.Ala116Asp Single submitter ⚠
- p.Ala268Thr Single submitter ⚠
- p.Ala287Val Single submitter ⚠
- p.Ala417Ser Single submitter ⚠
- p.Arg154Trp Single submitter ⚠
- p.Arg175Cys Single submitter ⚠
- p.Arg175His Single submitter ⚠
- p.Arg406Cys Single submitter ⚠
- p.Asn125Ser Single submitter ⚠
- p.Asn350Ser Single submitter ⚠
- p.Asn402Asp Single submitter ⚠
- p.Asp195Asn Single submitter ⚠
- p.Cys103Arg Single submitter ⚠
- p.Glu423Ala Single submitter ⚠
- p.Glu423Lys Single submitter ⚠
- p.Glu44Lys Single submitter ⚠
- p.Gly281Arg Single submitter ⚠
- p.Ile102Arg Single submitter ⚠
- p.Ile242Val Single submitter ⚠
- p.Ile36Met Single submitter ⚠
- p.Ile36Thr Single submitter ⚠
- p.Ile408Leu Single submitter ⚠
- p.Leu142Phe Single submitter
- p.Leu172Val Single submitter ⚠
- p.Leu81Ile Single submitter ⚠
- p.Lys427Glu Single submitter ⚠
- p.Lys441Glu Single submitter ⚠
- p.Lys452Arg Single submitter ⚠
- p.Lys66Asn Single submitter
- p.Met393Ile Single submitter ⚠
- p.Met429Thr Single submitter ⚠
- p.Met48Ile Single submitter ⚠
- p.Ser160Leu Single submitter ⚠
- p.Ser249Asn Single submitter ⚠
- p.Thr127Ser Single submitter ⚠
- p.Thr15Arg Single submitter ⚠
- p.Thr189Ala Single submitter ⚠
- p.Thr246Ala Single submitter ⚠
- p.Val288Leu Single submitter ⚠
- p.Val33Leu Single submitter ⚠
- p.Val437Ile Single submitter ⚠